Sildenafil inhibits human pulmonary artery smooth muscle cells proliferation by downregulation of capacitative Ca2+ entry

C. Wang, J. Wang, Y. Wang, C. Wang (Beijing, China)

Source: Annual Congress 2008 - Pulmonary vascular biology
Session: Pulmonary vascular biology
Session type: Thematic Poster Session
Number: 988
Disease area: Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Wang, J. Wang, Y. Wang, C. Wang (Beijing, China). Sildenafil inhibits human pulmonary artery smooth muscle cells proliferation by downregulation of capacitative Ca2+ entry. Eur Respir J 2008; 32: Suppl. 52, 988

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Bosentan stimulates the expression of cell cycle inhibitor p27(kip1) in pulmonary artery smooth muscle cells (PASMC)
Source: Annual Congress 2007 - Animal and ex vivo models of airway inflammation
Year: 2007


PKC inhibits BKCa channel activity in pulmonary arterial smooth muscle cells through multiple signaling pathways
Source: Eur Respir J 2006; 28: Suppl. 50, 159s
Year: 2006

Sildenafil modulates PDGF and Angiotensin II induced migration and proliferation in human pulmonary artery smooth muscle cells (PA-SMC)
Source: Eur Respir J 2002; 20: Suppl. 38, 227s
Year: 2002

Wnt5a down-regulated hypoxia-induced pulmonary arterial smooth muscle cell proliferation by inhibition of β-catenin
Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension
Year: 2010


Endothelin-1 inhibits TASK-1 in human pulmonary artery smooth muscle cells via phospholipase C-diacylglycerol-protein kinase C-pathway
Source: Annual Congress 2008 - Pathophysiology of pulmonary hypertension
Year: 2008


Mir-17 modulates smooth muscle cell markers, apoptosis and BMPR-II levels in human pulmonary artery smooth muscle cells
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: possible mechanisms
Source: Eur Respir J 2004; 24: Suppl. 48, 561s
Year: 2004

IL33 and TNFalpha synergistically enhance store operated Ca2+ entry in cultured human airway smooth muscle cells
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013


Caveolin-1 regulation of store-operated Ca2+ influx in human airway smooth muscle
Source: Eur Respir J 2012; 40: 470-478
Year: 2012



Increased p130Cas activity induces smooth muscle cell proliferation and migration in idiopathic pulmonary arterial hypertension
Source: Annual Congress 2011 - Experimental pulmonary hypertension
Year: 2011


Glutathionylation of IκB-α inhibits NF-κB dependent chemokine secretion in airway smooth muscle cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Effects of pinacidil, a KATP channel opener, on proliferation of cultured rabbit airway smooth muscle cells induced by endothelin-1
Source: Eur Respir J 2004; 24: Suppl. 48, 80s
Year: 2004

Activation of TRPV4 triggers ATP release and mast cell dependent contraction of airway smooth muscle (ASM)
Source: International Congress 2015 – Novel targets and strategies for the treatment of cough, asthma, rhinosinusitis and COPD
Year: 2015

Endothelin-1 downregulates BMP signaling in pulmonary artery smooth muscle cells
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012

Dexamethasone induces anti-remodelling effects in rat pulmonary arterial smooth muscle cells
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and cell biology
Year: 2012


Investigating redox sensitive sex differences in serotonin-induced proliferation and migration in rat pulmonary artery smooth muscle cells.
Source: International Congress 2017 – Experimental PH
Year: 2017

Functional expression of transient receptor potential vanilloid-related channels in chronically hypoxic human pulmonary arterial smooth muscle cells
Source: Annual Congress 2008 - Pathophysiology of pulmonary hypertension
Year: 2008

miR 16 modulates human pulmonary artery smooth muscle cell phenotype
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and cell biology
Year: 2012

Caspase-1 triggers smooth muscle cell proliferation in hypoxic pulmonary hypertension
Source: International Congress 2019 – Pulmonary hypertension: novelties from the bench
Year: 2019


Ryanodine receptors decant internal Ca2+ store in human and bovine airway smooth muscle
Source: Eur Respir J 2008; 32: 275-284
Year: 2008