Endothelin-1 inhibits TASK-1 in human pulmonary artery smooth muscle cells via phospholipase C-diacylglycerol-protein kinase C-pathway

B. Tang, Y. Li, N. Chandran, K. Katharina, S. Gabor, H. Popper, H. Olschewski, A. Olschewski (Graz, Austria)

Source: Annual Congress 2008 - Pathophysiology of pulmonary hypertension
Session: Pathophysiology of pulmonary hypertension
Session type: E-Communication Session
Number: 279
Disease area: Pulmonary vascular diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
B. Tang, Y. Li, N. Chandran, K. Katharina, S. Gabor, H. Popper, H. Olschewski, A. Olschewski (Graz, Austria). Endothelin-1 inhibits TASK-1 in human pulmonary artery smooth muscle cells via phospholipase C-diacylglycerol-protein kinase C-pathway. Eur Respir J 2008; 32: Suppl. 52, 279

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Endothelin-1 downregulates BMP signaling in pulmonary artery smooth muscle cells
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012

PKC inhibits BKCa channel activity in pulmonary arterial smooth muscle cells through multiple signaling pathways
Source: Eur Respir J 2006; 28: Suppl. 50, 159s
Year: 2006

Role of adenylate kinase 4 as a new metabolic regulator of pulmonary artery smooth muscle cells under hypoxia
Source: International Congress 2019 – Pulmonary hypertension: novelties from the bench
Year: 2019

Sildenafil modulates PDGF and Angiotensin II induced migration and proliferation in human pulmonary artery smooth muscle cells (PA-SMC)
Source: Eur Respir J 2002; 20: Suppl. 38, 227s
Year: 2002

Sildenafil inhibits human pulmonary artery smooth muscle cells proliferation by downregulation of capacitative Ca2+ entry
Source: Annual Congress 2008 - Pulmonary vascular biology
Year: 2008

Stable prostacyclin analogues treprostinil and iloprost activates KCa and two-pore domain TASK-1 channels in human pulmonary artery smooth muscle cells
Source: Annual Congress 2008 - Pathophysiology of pulmonary hypertension
Year: 2008

Bosentan stimulates the expression of cell cycle inhibitor p27(kip1) in pulmonary artery smooth muscle cells (PASMC)
Source: Annual Congress 2007 - Animal and ex vivo models of airway inflammation
Year: 2007


Role of Ca2+-dependent protein kinases and protein phosphatase in the effect of urotensin II on the rat airway smooth muscle cells proliferation
Source: Eur Respir J 2004; 24: Suppl. 48, 227s
Year: 2004

Involvement of protein kinase A (PKA) in the IL-1β induced MCP-1 production in human airway smooth muscle cells
Source: Eur Respir J 2001; 18: Suppl. 33, 353s
Year: 2001

Apoptosis signal-regulating kinase 1 regulates leukotirene D4-induced AP-1 activation in human airway smooth muscle cells
Source: Eur Respir J 2004; 24: Suppl. 48, 37s
Year: 2004

MAP kinase phosphatase 1 mediates glucocorticoid inhibition of CD38 expression in human airway smooth muscle
Source: Annual Congress 2008 - Basic science in asthma and COPD II
Year: 2008

MAP kinases mediate FGF-induced expression and release of VEGF in human airway smooth muscle cells: The role of azithromycin
Source: Annual Congress 2011 - Airway smooth muscle cells and fibroblasts: cell biology
Year: 2011


Role of interferons in endothelin-1 release from human pulmonary smooth muscle cells
Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension
Year: 2010

Increased expression of endothelinB receptors in the pulmonary arterial smooth muscle cells of fawn-hooded rat
Source: Eur Respir J 2001; 18: Suppl. 33, 416s
Year: 2001

Mir-17 modulates smooth muscle cell markers, apoptosis and BMPR-II levels in human pulmonary artery smooth muscle cells
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Alkalosis induce eNOS activation in human pulmonary arterial endothelial cells
Source: Eur Respir J 2001; 18: Suppl. 33, 73s
Year: 2001

Exogenous HSP60 stimulates airway smooth muscle cell remodeling via MAPK p38 pathway
Source: Virtual Congress 2020 – Monitoring of inflammation in remodelling
Year: 2020

Effect of endothelin-1 and bosentan on gene expressions in the cultured pulmonary artery smooth muscle cells
Source: Annual Congress 2010 - Pulmonary vascular diseases
Year: 2010

Hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: possible mechanisms
Source: Eur Respir J 2004; 24: Suppl. 48, 561s
Year: 2004

Upregulation of smooth muscle Rho-kinase protein expression in human asthma
Source: Eur Respir J, 55 (3) 1901785; 10.1183/13993003.01785-2019
Year: 2020