Source: Annual Congress 2008 - Pathophysiology of pulmonary hypertension
Disease area: Pulmonary vascular diseases



Rating:

Share or cite this content

Citations should be made in the following way:
G. Kwapiszewska, M. Wygrecka, L. Marsh, S. Schmitt, R. Troesser, A. Zakrzewicz, W. Seeger, O. Eickelberg, L. Fink, N. Weissmann (Giessen, Germany). Hypoxia-dependent Fhl-1 regulation leads to proproliferative effects in PASMC. Eur Respir J 2008; 32: Suppl. 52, 277

Member's Comments

No comment yet.

Related content which might interest you: The inhibitory mechanism of transferring iNOS gene to PASMCs on hypoxia induced proliferation Source: Eur Respir J 2002; 20: Suppl. 38, 88s Year: 2002 AntagomiR directed against miR-20a restores BMP signaling in hypoxia-induced pulmonary hypertension in vivo Source: Annual Congress 2011 - Molecular: pathology of infectious and inflammatory lung disease Year: 2011 TGFβ induced myofibroblast differentiation is independent of p38 activation, but requires TGFβR1 kinase activity and correlates with TGFβ-mediated SMAD signaling and TGFβ-responsive gene expression patterns in human lung fibroblasts Source: Eur Respir J 2004; 24: Suppl. 48, 718s Year: 2004 MKP-5 inhibition blunts fibrotic responses in-vitro and in-vivo through negative regulation of TGFB1-induced smad3-signalling Source: International Congress 2018 – New insights in the signalling pathways that underlie IPF pathophysiology Year: 2018 Glucocorticoids promote TGF-β signalling in lung fibroblasts by upregulating ligand and receptor expression, and uncoupling negative-feedback inhibition Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases Year: 2010 RB2/p130 gene-enhanced expression downregulates vascular endothelial growth factor expression and inhibits angiogenesis in vivo Source: Eur Respir J 2002; 20: Suppl. 38, 3s Year: 2002 AMPK signalling regulates Nrf2 localization and activity via sirtuins in a monocytic cell line Source: Annual Congress 2011 - Recent developments in COPD Year: 2011 Glutathione redox regulates TGF-β-induced Smad activation and fibrogenic effect in human airway Source: Eur Respir J 2007; 30: Suppl. 51, 496s Year: 2007 HMGA2 mediated epigenetic regulation of Gata6 controls epithelial WNT signaling during lung development Source: International Congress 2017 – Molecular biology of normal and abnormal lung development Year: 2017 Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension Source: Eur Respir J, 54 (6) 1900378; 10.1183/13993003.00378-2019 Year: 2019 Differential role of EPAC and PKA in the transduction of cAMP-mediated inhibition of human lung fibroblast proliferation and collagen synthesis Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation Year: 2009 Anti-inflammatory effect of bosentan on endothelin-1- and TNF-α-induced GMCSF expression in human airways smooth muscle cells – role of MAPkinases ERK-1,-2 Source: Annual Congress 2007 - Inflammatory cell biology Year: 2007 A critical role for mTOR regulated metabolic reprogramming during TGF-? induced fibroblast collagen synthesis Source: ERS Lung Science Conference 2017 Year: 2017 HIF dependent regulation of S100A4 protein in COPD induced vascular remodelling Source: Annual Congress 2010 - Pulmonary circulation I Year: 2010 DJ-1 and its anti-oxidative stress response regulates the expression of sirtuin-1 in COPD epithelial cells Source: International Congress 2017 – Translational studies of lung disease Year: 2017 PP221 – EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury Source: ERS Lung Science Conference 2021 Year: 2021 Endothelin-1 activates pro-inflammatory signalling pathway via destinct p38MAPK isoforms resulting in downregulation of nuclear p27kip1 Source: Annual Congress 2009 - Airway cell biology Year: 2009 Platelet-induced 5-LOX activity is associated with ROS-dependent ASMC proliferation Source: Annual Congress 2007 - Inflammatory cell biology Year: 2007 Selective inhibition of COX-2 by celecoxib exerts negative effects on endothelial progenitor cell proliferation and stimulates apoptosis in vitro Source: Eur Respir J 2005; 26: Suppl. 49, 368s Year: 2005