Phosphodiesterase-4 inhibition attenuates pulmonary inflammation in neonatal lung injury

de Visser Y. P., Walther F. J., Laghmani E. H., van Wijngaarden S., Nieuwland K., Wagenaar G. T. M.

Source: Eur Respir J 2008; 31: 633-644
Journal Issue: March
Disease area: Paediatric lung diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
de Visser Y. P., Walther F. J., Laghmani E. H., van Wijngaarden S., Nieuwland K., Wagenaar G. T. M.. Phosphodiesterase-4 inhibition attenuates pulmonary inflammation in neonatal lung injury. Eur Respir J 2008; 31: 633-644

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Effect of phosphodiesterase-4 inhibitor on the inflammation, oxidative damage and apoptosis in a saline lavage-induced model of acute lung injury
Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Year: 2018



Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia
Source: Eur Respir J 2009; 33: 861-870
Year: 2009



Treatment with proteinase inhibitor, BbCI, modulates inflammatory response, mechanic alterations, and remodeling on elastase-induced emphysema in mice
Source: Annual Congress 2012 - The many roads to lung injury
Year: 2012

The CDK4/6 inhibitor, palbociclib intensifies pulmonary inflammation in bleomycin-induced lung fibrosis
Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Year: 2020


Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation
Source: Eur Respir J 2007; 30: 423-428
Year: 2007



Rho-kinase inhibitor ameliorates bleomycin-induced chronic lung injury in neonatal rats
Source: Annual Congress 2011 - Issues in paediatric and neonatal intensive care
Year: 2011

Mechanisms of hypoxia-induced oedema reabsorption
Source: Annual Congress 2005 - An update on the mechanisms of pulmonary oedema formation and reabsorption
Year: 2005

Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury
Source: Eur Respir J 2013; 41: 165-176
Year: 2013



PD98059 attenuates the development of bleomycin-induced lung injury and fibrosis
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Repeated stress modulates lung tissue mechanics and induces pulmonary inflammation, remodelling and oxidative stress pathway activation in guinea pigs
Source: Annual Congress 2010 - Emerging mechanisms in lung injury
Year: 2010

Gabexate mesilate attenuates ischemia-reperfusion injury of lung grafts via the inhibition of neutrophil activation
Source: Annual Congress 2005 - Recent advances in graft dysfunction after lung transplantation
Year: 2005


Role of anti-proliferative therapy in PAH
Source: Research Seminar 2008 - The Pulmonary Circulation: Scleroderma-Related Pulmonary Arterial Hypertension
Year: 2008


Inhibition of the Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
Source: Annual Congress 2006 - Pulmonary circulation: inflammation and remodelling
Year: 2006


A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice
Source: Eur Respir J 2012; 40: 1475-1482
Year: 2012



Suppression of endotoxin-induced inflammation by taxol
Source: Eur Respir J 2007; 30: 429-435
Year: 2007



Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD
Source: Eur Respir J 2011; 38: 789-796
Year: 2011



Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats
Source: Eur Respir J 2001; 17: 1228-1235
Year: 2001



Prevention of hyperoxia-mediated pulmonary inflammation in neonatal rats by caffeine
Source: Eur Respir J 2013; 41: 966-973
Year: 2013



Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Source: Eur Respir J 2008; 31: 1334-1356
Year: 2008



Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment
Source: Eur Respir J 2012; 40: 416-423
Year: 2012