Hypoxia induced cardiac dysfunction maybe caused by increased IL-18 levels leading to dephosphorylation of Ca2+ handling proteins

K. O. Larsen, B. Lygren, I. Sjaastad, K. A. Krobert, G. Florholmen, K. Arnkvarn, F. O. Levy, O. H. Skjonsberg, K. Tasken, G. Christensen (Oslo, Norway)

Source: Annual Congress 2007 - Novel mediators of cellular pathology
Session: Novel mediators of cellular pathology
Session type: Electronic Poster Discussion
Number: 3066
Disease area: Pulmonary vascular diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. O. Larsen, B. Lygren, I. Sjaastad, K. A. Krobert, G. Florholmen, K. Arnkvarn, F. O. Levy, O. H. Skjonsberg, K. Tasken, G. Christensen (Oslo, Norway). Hypoxia induced cardiac dysfunction maybe caused by increased IL-18 levels leading to dephosphorylation of Ca2+ handling proteins. Eur Respir J 2007; 30: Suppl. 51, 3066

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Alveolar hypoxia induces generation of IL-18 in mice. IL-18 reduces phosphorylation of the calcium handling protein phospholamban in cardiomyocytes
Source: Annual Congress 2008 - Pathophysiology of pulmonary hypertension
Year: 2008


S-CMC-Lys reduces oxidative stress of respiratory cells and increases GSH intracellular content
Source: Annual Congress 2011 - Lung cell biology
Year: 2011

Inhibition of ER stress suppresses IL-13 induced airway epithelial remodeling
Source: International Congress 2019 – COPD, asthma and rhinitis: from cellular mechanisms to patients’ clinical responses
Year: 2019

Mitochondrial dysfunction in airway epithelium increases pro-inflammatory IL-8, impairs barrier function and reduces glucocorticoid responsiveness
Source: Annual Congress 2011 - Lung cell biology
Year: 2011

N-Acetylcysteine inhibits eotaxin and MCP-1 release in human airway smooth muscle cells in vitro through the inhibition of ROS production, resulting in a decrease of p38 MAP kinase activation
Source: Eur Respir J 2002; 20: Suppl. 38, 170s
Year: 2002

The nitration mediated inhibition of Rac1 is involved in the endothelial barrier dysfunction induced by lipopolysaccharide
Source: Annual Congress 2011 - Lung cell injury and repair
Year: 2011

Cigarette-decreased NAD/SIRT1 aggravates pulmonary fibrosis by promoting senescence of alveolar type 2 cells through autophagy inhibition and mitochondrial oxidative stress induction
Source: Virtual Congress 2020 – Idiopathic pulmonary fibrosis and interstitial lung disease: progression, genes and more
Year: 2020

Tankyrase(TNKS) inhibiting autophagy promotes the TGF-ß induced EMT process in vitro and Bleomycin(BLM) induced pulmonary fibrosis in rats
Source: International Congress 2019 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2019

Hypoxia induces differential acute and chronic adaptations in regulation of skeletal muscle protein turnover
Source: Annual Congress 2011 - Measuring physical activity and exercise performance in chronic lung disease: implications for rehabilitation
Year: 2011


Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production
Source: ERJ Open Res, 6 (4) 00159-2020; 10.1183/23120541.00159-2020
Year: 2020



iNOS inhibition modulates lung tissue inflammation via oxidative stress pathway activation
Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD
Year: 2008


Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016

CAM-kinase II inhibition and protein kinase C activation combine synergistically to initiate ciliary beat frequency despite cellular hypothermia
Source: Eur Respir J 2002; 20: Suppl. 38, 88s
Year: 2002

PP223 – N-Acetyl cysteine rescues neonatal lethality caused by HRas/NRas deficiency by improving lung maturation and decreasing oxidative stress
Source: ERS Lung Science Conference 2021
Year: 2021

LATE-BREAKING ABSTRACT: Defect of HDAC7 causes impaired VEGF expression in response to hypoxia in COPD
Source: Annual Congress 2013 –New insights into epigenetic mechanisms in the lung
Year: 2013

Inflammation induced conformational changes in Z alpha-1 antirypsin promotes lung Z-AT cell damage
Source: Annual Congress 2013 –The multiple faces of stress in lung injury
Year: 2013

Loss of CFTR causes endothelial barrier failure in pneumonia via inhibition of WNK1 and TRPV4 activation
Source: International Congress 2017 – From respiratory muscles to acute respiratory failure
Year: 2017

Increased STIM1 expression induced by cigarette smoking extracts regulates the proliferation and production of inflammatory cytokines in human airway smooth muscle cells
Source: Virtual Congress 2020 – Effects of environmental exposures on lung pathology
Year: 2020

Bile acid receptor accelerates to the lung cancer process induced by lung fibroblast-tumor cells interaction, with high activation of phosphorylated STAT3 and alteration of cytokine secretion
Source: International Congress 2017 – Lung cancer - basic science: the latest results from the bench
Year: 2017

Elevated osteoprotegerin in COPD is potentially regulated by oxidative stress dependent glycogen synthase kinase-3β and β-catenin signalling
Source: Annual Congress 2011 - Molecular: pathology of infectious and inflammatory lung disease
Year: 2011