Altered expression of the Smad signalling pathway: implications for COPD pathogenesis

Zandvoort A., Postma D. S., Jonker M. R., Noordhoek J. A., Vos J. T. W. M., van der Geld Y. M., Timens W.

Source: Eur Respir J 2006; 28: 533-541
Journal Issue: September
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Zandvoort A., Postma D. S., Jonker M. R., Noordhoek J. A., Vos J. T. W. M., van der Geld Y. M., Timens W.. Altered expression of the Smad signalling pathway: implications for COPD pathogenesis. Eur Respir J 2006; 28: 533-541

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Cytokines in chronic obstructive pulmonary disease
Source: Eur Respir J 2001; 18: 50S-59S
Year: 2001



Transforming Growth factor beta-1 and Smad signaling has the potential to drive EMT-related changes in smokers and COPD
Source: International Congress 2016 – How the understanding og molecular and genomic crosstalk is helping to diagnose lung disease
Year: 2016

RhoA signalling influences cyclin D1 expression and associated fibroblast turnover: implications for idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2006 - Lung vascular and parenchymal remodeling
Year: 2006


Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-?B and EGFR pathways
Source: Eur Respir J 2010; 36: 1425-1435
Year: 2010



Hypoxia inducible factor-1? in human emphysema lung tissue
Source: Eur Respir J 2011; 37: 775-783
Year: 2011



Epidermal growth factor receptor (EGFR) activation is required for TGFbeta1-induced epithelial-mesenchymal transition (EMT) in idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Targeting the mTOR signaling pathway to inhibit lung cell senescence in chronic obstructive pulmonary disease (COPD)
Source: ERS Lung Science Conference 2017
Year: 2017

Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension
Source: Eur Respir J 2016; 48: 470-483
Year: 2016



The contribution of transforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma
Source: Eur Respir J 2006; 27: 208-229
Year: 2006



Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis
Source: Eur Respir J 2006; 27: 957-963
Year: 2006



Wnt11 inhibits effects of transforming growth factor-beta1 (TGFbeta1) on lung epithelial phenotype
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013


Role of tumour necrosis factor-α receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema
Source: Eur Respir J 2006; 28: 102-112
Year: 2006



Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases
Source: Eur Respir J 2008; 32: 1068-1081
Year: 2008



The role of integrins in pulmonary fibrosis
Source: Eur Respir Rev 2008; 17: 157-162
Year: 2008



Egr-1 regulates muc5ac expression through activator protein-1 (AP-1) in chronic airway inflammation diseases
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015


Haemophilus influenzae (NTHi) up-regulates acute inflammation in human lung tissue and causes downregulation of transforming growth factor-beta (TGF-beta) – A possible role of NTHi in remodeling processes in human lung tissue
Source: Annual Congress 2010 - Novel cellular mechanisms in lung disease
Year: 2010

Expression and functional analysis of the transforming growth factor (TGF)-β superfamily in pulmonary arterial hypertension: role of PAI-1 in disease progression
Source: Eur Respir J 2007; 30: Suppl. 51, 53s
Year: 2007

Transforming growth factor-? gene polymorphisms in different phenotypes of sarcoidosis
Source: Eur Respir J 2011; 37: 169-175
Year: 2011



The matrix-fibroblast interplay contributes to HIF-1 alpha pathway activation: a possible therapeutic target in idiopathic pulmonary fibrosis (IPF)
Source: Virtual Congress 2020 – Elucidating the mechanisms underlying lung repair and exploring therapeutic strategies in vitro
Year: 2020




Identification and quantification of NF-kB transcription factor in chronic obstructive pulmonary disease
Source: Eur Respir J 2001; 18: Suppl. 33, 316s
Year: 2001