Influence of food intake on the pharmacokinetics of roflumilast, a new, orally active, selective PDE4 inhibitor

M. David, T. Bethke, M. Hartmann, A. Baumgartner, N. Neuhäuser, K. Zech, W. Wurst (Konstanz, Germany)

Source: Annual Congress 2001 - Asthma, general
Session: Asthma, general
Session type: Thematic Poster Session
Number: 377
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. David, T. Bethke, M. Hartmann, A. Baumgartner, N. Neuhäuser, K. Zech, W. Wurst (Konstanz, Germany). Influence of food intake on the pharmacokinetics of roflumilast, a new, orally active, selective PDE4 inhibitor. Eur Respir J 2001; 16: Suppl. 31, 377

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Smoking has no effect on the pharmacokinetics of roflumilast, a new, orally active, selective PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

High oral absolute bioavailability of roflumilast, a new, orally active, once daily PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 20s
Year: 2001

No interaction of roflumilast, a new, orally active, selective PDE4 inhibitor, with inhaled salbutamol
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Roflumilast, a new, orally active, selective PDE4 inhibitor, does not interact with inhaled budesonide
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, is effective in the treatment of asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 303s
Year: 2002

Dose-dependent inhibitory effect of Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, on allergen-induced early and late asthmatic reaction
Source: Eur Respir J 2002; 20: Suppl. 38, 110s
Year: 2002

Effect of CYP3A4 inhibitors verapamil and itraconazole on the pharmacokinetics of AZD7986, an oral DPP1 inhibitor
Source: International Congress 2017 – Asthma management
Year: 2017


Comparison of roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, with beclomethasone dipropionate in asthma control
Source: Eur Respir J 2002; 20: Suppl. 38, 304s
Year: 2002

Suppressive effect of novel phosphodiesterase4 (PDE4) inhibitor ONO-6126 on TNF-α release was increased after repeated oral administration in healthy Japanese subjects
Source: Annual Congress 2003 - Novel drugs under development for the treatment of respiratory diseases
Year: 2003


Safety, tolerability and pharmacokinetics of a new inhaled once-daily phosphodiesterase (PDE) 4 inhibitor in healthy volunteers
Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine
Year: 2013

Roflumilast, a selective phosphodiesterase 4 inhibitor, shows efficacy and safety in the long-term treatment of asthma
Source: Eur Respir J 2003; 22: Suppl. 45, 203s
Year: 2003

The bronchodilatory and anti-inflammatory effect of MT-810, a novel selective phosphodiesterase-4 (PDE4) inhibitor
Source: Eur Respir J 2006; 28: Suppl. 50, 434s
Year: 2006

The novel selective PDE4 inhibitor roflumilast: early onset of efficacy in asthma
Source: Eur Respir J 2003; 22: Suppl. 45, 203s
Year: 2003

Efficacy and safety of four doses of CHF6001, a novel inhaled phosphodiesterase-4 inhibitor (PDE4i), in patients with moderate-to-severe COPD
Source: International Congress 2019 – COPD clinical trials: new molecules and novel insights
Year: 2019



Pharmacokinetic characteristics of roflumilast and its active metabolite roflumilast-N-oxide are not affected by food intake
Source: Eur Respir J 2002; 20: Suppl. 38, 109s
Year: 2002

Roflumilast N-oxide, a selective PDE4 inhibitor, curbs platelet-leukocyte interactions
Source: Annual Congress 2011 - Translational models of disease
Year: 2011


The novel elastase inhibitor BAY 85-8501: Bioavailability and Food effect study to evaluate pharmacokinetics of tablet formulations
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014


Safety, tolerability, pharmacokinetics and pharmacodynamics after repeated once or twice daily RVT-1201, a TPH inhibitor for treatment of PAH
Source: International Congress 2019 – Pulmonary hypertension: clinical
Year: 2019


‘Total PDE4 inhibitory activity‘: a concept for evaluating pharmacokinetic alterations of roflumilast and roflumilast N-oxide in special populations and drug-drug interactions
Source: Eur Respir J 2006; 28: Suppl. 50, 436s
Year: 2006

Safety, tolerability and pharmacokinetics (PK) of repeated doses of GSK573719 inhalation powder, a new long-acting muscarinic antagonist, in healthy adults
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011