Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome

Carmela Morrone, Natalia F. Smirnova, Aicha Jeridi, Nikolaus Kneidinger, Christine Hollauer, Jonas Christian Schupp, Naftali Kaminski, Dieter Jenne, Oliver Eickelberg, Ali Önder Yildirim

Source: Eur Respir J, 57 (5) 2001416; 10.1183/13993003.01416-2020
Journal Issue: May

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Carmela Morrone, Natalia F. Smirnova, Aicha Jeridi, Nikolaus Kneidinger, Christine Hollauer, Jonas Christian Schupp, Naftali Kaminski, Dieter Jenne, Oliver Eickelberg, Ali Önder Yildirim. Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome. Eur Respir J, 57 (5) 2001416; 10.1183/13993003.01416-2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Neutrophil mediated matrixmetalloproteinase activity is increased in bronchiolitis obliterans syndrome after lung transplantation
Source: Eur Respir J 2004; 24: Suppl. 48, 179s
Year: 2004

Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway
Source: Eur Respir J 2011; 37: 1237-1247
Year: 2011



Matrix metalloproteinase-9 in bronchiolitis obliterans syndrome after lung transplantation
Source: Eur Respir J 2005; 25: 494-501
Year: 2005



In vitro model to study the correlation between neutrophils and miR21 expression: a role in Bronchiolitis obliterans syndrome
Source: International Congress 2019 – Lung transplantation: from basic science to clinical outcomes
Year: 2019


Balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in the development of bronchiolitis obliterans syndrome after lung transplantation
Source: Eur Respir J 2003; 22: Suppl. 45, 327s
Year: 2003

Antimicrobial peptides in lung transplant recipients with bronchiolitis obliterans syndrome
Source: Eur Respir J 2008; 32: 670-677
Year: 2008



Genetic polymorphism in the MMP7 gene correlates with the development of bronchiolitis obliterans syndrome
Source: Annual Congress 2009 - Bronchiolitis obliterans syndrome after lung transplantation: pathophysiology and treatment options
Year: 2009


Macrolides inhibit cytokine production by alveolar macrophages in bronchiolitis obliterans organizing pneumonia
Source: Annual Congress 2012 - Diffuse parenchymal lung disease II
Year: 2012


Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation
Source: Eur Respir J 2014; 43: 221-232
Year: 2004



Immunohistochemical characterization of inflammatory cells in childhood bronchiolitis obliterans
Source: Eur Respir J 2001; 18: Suppl. 33, 292s
Year: 2001

Bronchiolitis obliterans syndrome and bronchiolitis obliterans in lung transplantation: will a pathologist and a physician ever meet?
Source: ISSN=1025-448x, ISBN=1-904097-33-2, page=55
Year: 2004

Mediators produced by apoptotic endothelial cells activates Twist and Snail; role in bronchiolitis obliterans
Source: Annual Congress 2010 - Lung cell biology and immunology
Year: 2010

Bronchiolitis obliterans syndrome after lung transplantation: diagnosis and treatment
Source: ISSN=1025-448x, ISBN=1-904097-33-2, page=19
Year: 2004

Calprotectin as new sensitive marker of neutrophilic inflammation in patients with bronchiolitis obliterans
Source: International Congress 2018 – Paediatric respiratory infections: mechanistic insights and clinical outcomes
Year: 2018


Bronchiolitis obliterans (BO) treatment with collagen with collagen type V and corticoid by nasal-drop in Balb-c mice (BM)
Source: Eur Respir J 2005; 26: Suppl. 49, 732s
Year: 2005

Chronic lung allograft rejection: prevalence, pathology, risk factors and pathophysiology
Source: ISSN=1025-448x, ISBN=1-904097-33-2, page=1
Year: 2004

Validation of a bronchiolitis obliterans rat lung transplant model: the role of MMP-9
Source: Eur Respir J 2006; 28: Suppl. 50, 778s
Year: 2006

The role of cytomegalovirus in the development of bronchiolitis obliterans syndrome
Source: International Congress 2015 – Pathogenic mechanisms of lung transplant complications: a focus on CLAD
Year: 2015

The mononuclear phagocyte system contributes to fibrosis in post-transplant obliterans bronchiolitis
Source: Eur Respir J, 57 (3) 2000344; 10.1183/13993003.00344-2020
Year: 2021



Putting the spotlight on macrophage-derived cathepsin in the pathophysiology of obliterative bronchiolitis
Source: Eur Respir J, 57 (5) 2004607; 10.1183/13993003.04607-2020
Year: 2021