Pharmacokinetic characteristics of roflumilast and its active metabolite roflumilast-N-oxide are not affected by food intake

A. Drollmann, A. Huennemayer, M. Hartmann, B. Hauns, K. Zech, T. D. Bethke, W. Wurst (Konstanz, Germany)

Source: Annual Congress 2002 - Asthma and COPD: pharmacology
Session: Asthma and COPD: pharmacology
Session type: Thematic Poster Session
Number: 747
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Drollmann, A. Huennemayer, M. Hartmann, B. Hauns, K. Zech, T. D. Bethke, W. Wurst (Konstanz, Germany). Pharmacokinetic characteristics of roflumilast and its active metabolite roflumilast-N-oxide are not affected by food intake. Eur Respir J 2002; 20: Suppl. 38, 747

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Pharmacokinetics of roflumilast and its active metabolite roflumilast N-oxide are not influenced by erythromycin
Source: Eur Respir J 2004; 24: Suppl. 48, 128s
Year: 2004

Effects of steady-state female hormones on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011


Pharmacokinetic characteristics of roflumilast administered in gradually increasing doses of 500μg to 1000μg are dose-linear in healthy subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 108s
Year: 2002

Influence of food intake on the pharmacokinetics of roflumilast, a new, orally active, selective PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 42s
Year: 2001

Roflumilast and its active metabolite roflumilast N-oxide do not interact with R- and S-warfarin
Source: Eur Respir J 2003; 22: Suppl. 45, 103s
Year: 2003

Effects of steady-state enoxacin on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Annual Congress 2009 - New bronchodilators
Year: 2009


Pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects after a single, oral dose of 500µg roflumilast in the morning versus evening
Source: Eur Respir J 2003; 22: Suppl. 45, 102s
Year: 2003

‘Total PDE4 inhibitory activity‘: a concept for evaluating pharmacokinetic alterations of roflumilast and roflumilast N-oxide in special populations and drug-drug interactions
Source: Eur Respir J 2006; 28: Suppl. 50, 436s
Year: 2006

Effect of ketoconazole on the pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Eur Respir J 2006; 28: Suppl. 50, 435s
Year: 2006

Pharmacokinetics of roflumilast and its active metabolite roflumilast-N-oxide in middle aged and young subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 109s
Year: 2002

High oral absolute bioavailability of roflumilast, a new, orally active, once daily PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 20s
Year: 2001

Equivalent pharmacokinetics of the active metabolite of ciclesonide when using the ciclesonide-MDI with and without a spacer
Source: Eur Respir J 2004; 24: Suppl. 48, 583s
Year: 2004

Absorption behavior of riociguat (BAY 63-2521): Bioavailability, food effects, and dose-proportionality
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


Smoking has no effect on the pharmacokinetics of roflumilast, a new, orally active, selective PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

No relevant pharmacokinetic drug–drug interaction between nintedanib and pirfenidone
Source: Eur Respir J, 53 (1) 1801060; 10.1183/13993003.01060-2018
Year: 2019



Safety, pharmacokinetics, and pharmacodynamics of TD-8236, an inhaled pan-JAK inhibitor, following single- and multiple-ascending doses in healthy volunteers and mild asthmatics
Source: Virtual Congress 2021 – Clinical trials in airway diseases: novel treatments and new evidence
Year: 2021



Tpi 1020, a novel inhaled anti-inflammatory drug, has a different pharmacokinetic profile and lower effect on urinary free cortisol as compared to budesonide
Source: Annual Congress 2009 - Translational research/biomarkers
Year: 2009

The effects of multiple dosing of ketoconazole on the pharmacokinetics of a single dose ambrisentan
Source: Annual Congress 2008 - Pulmonary hypertension II
Year: 2008

Pharmacokinetic factors affecting airway selectivity of inhaled steroids – role of prodrug conversion and absorption
Source: Eur Respir J 2004; 24: Suppl. 48, 347s
Year: 2004

Pharmacokinetics and pharmacodynamics of ciclesonide and its active principle after inhalative and intravenous administration in healthy subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 110s
Year: 2002