PP221 – EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury

Huy Le, Germany

Source: ERS Lung Science Conference 2021
Number: 89
Disease area: Airway diseases

E-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Huy Le, Germany. PP221 – EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury. ERS Lung Science Conference 2021

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
PTEN deficiency in alveolar type 2 cells accelerates cellular senescence, disrupts epithelial–mesenchymal and mitochondrial homeostasis, and induces age-related emphysema
Source: International Congress 2019 – Cellular metabolism and immune senescence in lung pathology
Year: 2019



HIF dependent regulation of S100A4 protein in COPD induced vascular remodelling
Source: Annual Congress 2010 - Pulmonary circulation I
Year: 2010

Inhibition of hypoxia-induced phenotype alterations through epithelial-mesenchymal transition (EMT) in lung cancer by gene modulation of phosphorylation sites in tumor suppressor PTEN
Source: Annual Congress 2011 - Lung cancer: molecular pathology and functional genomics
Year: 2011

HMGA2 mediated epigenetic regulation of Gata6 controls epithelial WNT signaling during lung development
Source: International Congress 2017 – Molecular biology of normal and abnormal lung development
Year: 2017

Involvement of proteasome inhibition and p53 accumulation in epithelial apoptosis of lung injury
Source: Eur Respir J 2005; 26: Suppl. 49, 101s
Year: 2005

Acrolein induces airway remodeling in mice via NF-κB pathway
Source: Annual Congress 2009 - Preclinical models in drug development
Year: 2009



Fas activation impairs the alveolar epithelial function in mice by mechanisms involving apoptosis
Source: Annual Congress 2011 - Anti-inflammatory strategies in acute lung injury
Year: 2011

YI02 - Activation of Wnt/beta-catenin signaling promotes lung epithelial repair in emphysema
Source: Lung Science Conference 2012 - Rebuilding a diseased lung: Repair and regeneration
Year: 2012

The role of epithelial Pten in programmed cellular senescence during lung development
Source: International Congress 2018 – Molecular and cellular determinants of the developing lung
Year: 2018

Tankyrase(TNKS) inhibiting autophagy promotes the TGF-ß induced EMT process in vitro and Bleomycin(BLM) induced pulmonary fibrosis in rats
Source: International Congress 2019 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2019

TGFβ overproduction in asthma reduces the epithelial repair by down-regulating the leptin/leptin receptor pathway
Source: Eur Respir J 2007; 30: Suppl. 51, 59s
Year: 2007

TGFβ induced myofibroblast differentiation is independent of p38 activation, but requires TGFβR1 kinase activity and correlates with TGFβ-mediated SMAD signaling and TGFβ-responsive gene expression patterns in human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 718s
Year: 2004

The role of FoxO transcription factors in normal and aberrant late lung development
Source: International Congress 2017 – Molecular pathways in lung development
Year: 2017

ER-stress a link to lung remodelling
Source: Annual Congress 2013 –Inflammasomes in lung diseases
Year: 2013


miR-146a-5p plays an essential role in the aberrant epithelial–fibroblast cross-talk in COPD
Source: Eur Respir J, 49 (5) 1602538; 10.1183/13993003.02538-2016
Year: 2017



miR-184 mediates hyperoxia-induced injury by targeting cell death and angiogenesis signalling pathways in the developing lung
Source: Eur Respir J, 58 (3) 1901789; 10.1183/13993003.01789-2019
Year: 2021



Investigating the role of AKAP13 on epithelial cell TGFß activation
Source: International Congress 2019 – New mechanistic insights into pulmonary fibrosis
Year: 2019

COX inhibition enhances remodelling processes in human lung fibroblasts
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Hypoxia-induced methylation of the Thy-1 promoter is associated with transcriptional repression in human primary lung fibroblasts
Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases
Year: 2010