Characterising the cardiovascular safety profile of inhaled muscarinic receptor antagonists

Daiana Stolz, Mario Cazzola

Source: Eur Respir Monogr 2020; 88: 238-250
Disease area: Airway diseases

Congress or journal article abstractFull text journal article

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Daiana Stolz, Mario Cazzola. Characterising the cardiovascular safety profile of inhaled muscarinic receptor antagonists. Eur Respir Monogr 2020; 88: 238-250

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The efficacy and safety of long-acting muscarinic antagonist treatment for COPD
Source: International Congress 2019 – Advances in chronic obstructive pulmonary disease and asthma
Year: 2019


In vitro pharmacological profile of CHF 5407, a potent, long-acting and selective muscarinic M3 receptor antagonist
Source: Eur Respir J 2007; 30: Suppl. 51, 25s
Year: 2007

Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond
Source: Eur Respir J, 56 (2) 2001610; 10.1183/13993003.01610-2020
Year: 2020



In vivo potent and long-lasting bronchodilator activity of muscarinic M3 receptor antagonist CHF5407
Source: Eur Respir J 2007; 30: Suppl. 51, 26s
Year: 2007

A novel dual-agonist challenge model in guinea pigs for assessment of individual and combined muscarinics antagonists and b2 adrenoceptor agonists bronchodilator efficacy
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011

Long-acting muscarinic antagonists: a potential add-on therapy in the treatment of asthma?
Source: Eur Respir Rev 2015; 25: 54-64
Year: 2016



Dose-related efficacy of GSK573719, a new long-acting muscarinic receptor antagonist (LAMA) offering sustained 24-hour bronchodilation, in COPD
Source: Annual Congress 2011 - Bronchodilators in asthma and COPD
Year: 2011

Superior in vivo efficacy of macitentan: Comparison to other endothelin receptor antagonists
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

An oral selective M3 cholinergic receptor antagonist in COPD
Source: Eur Respir J 2006 Oct 01;28(4):772-780
Year: 2006



Safety and toleration of pf-00610355, a novel inhaled long acting β2 adrenoreceptor agonist
Source: Annual Congress 2009 - New bronchodilators
Year: 2009

Efficacy and safety of Long-acting Beta-agonists+Long-acting muscarinic antagonists vs Long-acting Beta-agonists+Inhaled corticosteroids in COPD: a meta-analysis
Source: International Congress 2017 – Primary care diagnosis, assessment and management of COPD
Year: 2017

Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids
Source: Eur Respir J 2006; 27: 511-516
Year: 2006



Effect of AVE5883, a dual NK1/NK2 receptor antagonist, on airway responsiveness to neurokinin A in asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 219s
Year: 2004

Unique receptor dissociation kinetics of the novel endothelin receptor antagonist macitentan
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Effect of long-acting muscarinic antagonist (LAMA) on 24-hour physical behaviours in COPD
Source: Virtual Congress 2020 – Reviews and novel insights into pulmonary rehabilitation
Year: 2020


Lack of relevant pharmacokinetic interactions between the new dual endothelin receptor antagonist macitentan and sildenafil in healthy subjects
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


Safety and efficacy of the inhaled pan-selectin antagonist bimosiamose in patients with COPD
Source: Eur Respir J 2007; 30: Suppl. 51, 613s
Year: 2007

Efficacy of sitaxsentan, an endothelin-A receptor antagonist in PAH in traditional vs. expanded study populations
Source: Eur Respir J 2004; 24: Suppl. 48, 109s
Year: 2004

The dual endothelin receptor antagonist bosentan reduces TNFα induced GM-CSF release more effectively than the endothelin A receptor antagonist ambrisentan
Source: Annual Congress 2010 - Airway smooth muscle cells
Year: 2010

Vasopressin is involved in endothelin receptor antagonist-induced fluid retention in rat. Differential effect of selective ETA and dual ETA/ETB receptor antagonists
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012