GB001 potently inhibits PGD2 metabolite-induced DP2-mediated cell signaling and eosinophil activation

S. Murphy (San Diego, United States of America), T. Ismaili (San Diego, United States of America), K. Taylor Meadows (San Diego, United States of America), S. Sahdeo (San Diego, United States of America), H. Ortega (San Diego, United States of America), L. Carter (San Diego, United States of America), L. Salter-Cid (San Diego, United States of America)

Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms
Session: Asthma science: novel targets and mechanisms
Session type: E-poster session
Number: 2902
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Murphy (San Diego, United States of America), T. Ismaili (San Diego, United States of America), K. Taylor Meadows (San Diego, United States of America), S. Sahdeo (San Diego, United States of America), H. Ortega (San Diego, United States of America), L. Carter (San Diego, United States of America), L. Salter-Cid (San Diego, United States of America). GB001 potently inhibits PGD2 metabolite-induced DP2-mediated cell signaling and eosinophil activation. 2902

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Fevipiprant inhibits eosinophil activation induced by multiple metabolites of prostaglandin D2
Source: International Congress 2019 – COPD, asthma and rhinitis: from cellular mechanisms to patients’ clinical responses
Year: 2019


Curcumin induces glutathione biosynthesis and inhibits NF-κB activation and interleukin-8 release in alveolar epithelial cells
Source: Eur Respir J 2004; 24: Suppl. 48, 29s
Year: 2004

Dexamethasone potently induces human basophil apoptosis
Source: Eur Respir J 2002; 20: Suppl. 38, 29s
Year: 2002

COX-1 driven biosynthesis of PGD2 during activation of human mast cells prevents formation of other prostanoids
Source: Virtual Congress 2020 – Novel molecular markers and targets for asthma phenotypes
Year: 2020


N-Acetylcysteine inhibits eotaxin and MCP-1 release in human airway smooth muscle cells in vitro through the inhibition of ROS production, resulting in a decrease of p38 MAP kinase activation
Source: Eur Respir J 2002; 20: Suppl. 38, 170s
Year: 2002

TNF-α inhibits human eosinophil apoptosis by activating p55 receptor and NF-κB
Source: Eur Respir J 2001; 18: Suppl. 33, 162s
Year: 2001

Effects of endothelin-1 on MAPK activation, IL-6 production and cell proliferation in normal human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 454s
Year: 2004

Effect of PDE4 inhibitors on MAPK activation and IL-8 production on A549 cells following the induction of oxidative stress
Source: Eur Respir J 2005; 26: Suppl. 49, 99s
Year: 2005

Effects of TGF-beta and budesonide on MAPK phosphorylation, IL-6/IL-11 secretion, and cell proliferation in human lung fibroblasts
Source: Eur Respir J 2006; 28: Suppl. 50, 662s
Year: 2006

The PDE4-inhibitors roflumilast and rolipram modulate fibroblast collagen-gel contraction and chemotaxis mediated by autocrine PGE2 synthesis induced by TGF-β1
Source: Eur Respir J 2005; 26: Suppl. 49, 214s
Year: 2005

Eosinophil adhesion to cholinergic nerve cells induces NFκB activation via the interleukin-1 receptor associated kinase (IRAK) pathway and upregulates ICAM-1 expression
Source: Eur Respir J 2003; 22: Suppl. 45, 10s
Year: 2003

The angiogenic integrin a9b1 promotes cell migration through Src-dependent activation of nitric oxide synthesis
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009

Endothelin-1 activates pro-inflammatory signalling pathway via destinct p38MAPK isoforms resulting in downregulation of nuclear p27kip1
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Platelet-induced 5-LOX activity is associated with ROS-dependent ASMC proliferation
Source: Annual Congress 2007 - Inflammatory cell biology
Year: 2007


Effects of budesonide on p38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Selective inhibition of COX-2 by celecoxib exerts negative effects on endothelial progenitor cell proliferation and stimulates apoptosis in vitro
Source: Eur Respir J 2005; 26: Suppl. 49, 368s
Year: 2005

A differential role for ceramide kinase in antigen/FcεRI mediated mast cell activation and function
Source: Eur Respir J 2006; 28: Suppl. 50, 231s
Year: 2006

Inhibitory effects of the IL-6 receptor superantagonist SANT7 on MAP kinase phosphorylation and cell proliferation induced by IL-6 and TGF-beta1 in human lung fibroblasts
Source: Annual Congress 2008 - Clinical aspects of interstitial lung disease
Year: 2008

Glucocorticoids promote TGF-β signalling in lung fibroblasts by upregulating ligand and receptor expression, and uncoupling negative-feedback inhibition
Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases
Year: 2010

Curcumin restores glucocorticoid function and inhibits cigarette smoke-mediated IL-8 release in oxidant stressed monocytic U937 cells
Source: Eur Respir J 2005; 26: Suppl. 49, 215s
Year: 2005