Evidence for nuclear translocation of MAP kinases and the transcription factors NFκB and AP-1 in human bronchial epithelium in-vivo following exposure to diesel exhaust

J. Pourazar, A. Blomberg, A. J. Frew, R. Helleday, F. J. Kelly, B. Rudell, S. S. Salvi, S. T. Holgate, J. Samet, T. Sandström (Umeå, Linköping, Sweden; Southampton, London, United Kingdom; Chapel Hill, United States Of America)

Source: Annual Congress 2002 - Effects of air pollution on lung cells
Session: Effects of air pollution on lung cells
Session type: Oral Presentation
Number: 263
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Pourazar, A. Blomberg, A. J. Frew, R. Helleday, F. J. Kelly, B. Rudell, S. S. Salvi, S. T. Holgate, J. Samet, T. Sandström (Umeå, Linköping, Sweden; Southampton, London, United Kingdom; Chapel Hill, United States Of America). Evidence for nuclear translocation of MAP kinases and the transcription factors NFκB and AP-1 in human bronchial epithelium in-vivo following exposure to diesel exhaust. Eur Respir J 2002; 20: Suppl. 38, 263

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The effect of diesel emission exposure on intracellular signaling pathways of primary human bronchial epithelial cells
Source: International Congress 2017 – Cigarette smoke and particulate matter: basic science and clinical aspects
Year: 2017

Involvement of NFkB activation and c-JUN phosphorylation in bronchial epithelial cells by CD-40-CD40L pathway
Source: Eur Respir J 2002; 20: Suppl. 38, 573s
Year: 2002

Exposure to LPS induces the upregulation of p38 MAPK in human bronchial epithelium in vivo
Source: Eur Respir J 2003; 22: Suppl. 45, 459s
Year: 2003

Regulation of human lung epithelial cell numbers by diesel exhaust particles
Source: Eur Respir J 2006; 27: 705-713
Year: 2006



Cigarette smoke enhances beta-defensin 2 expression in rat airways via nuclear factor-kappa-B activation
Source: Eur Respir J 2010; 36: 638-645
Year: 2010



Phosphorylation of p53 and H2AX histone variant in response to air pollution particulates and oxidative stress
Source: Eur Respir J 2004; 24: Suppl. 48, 106s
Year: 2004

Activation of both transcription factors STAT5 and IRF-1 is insensitive to corticosteroids in asthmatic bronchial smooth muscle cells exposed to TNFα/IFNγ
Source: Annual Congress 2012 - Cellular signalling mechanisms in the airways
Year: 2012

Welding fumes-induced lung inflammation is caused by soluble transition metals via activation of NF-κB and AP-1
Source: Eur Respir J 2004; 24: Suppl. 48, 107s
Year: 2004

Korean Red Ginseng inhibits diesel exhaust particles-induced MUC5AC/B expression and inflammation through suppressing TLR4 and NF-kB signaling pathway in vitro and in vivo
Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Year: 2019


Tobacco smoke induces muc5AC expression in normal bronchial epithelial cells trough activation of the NADPH system in a mechanism involving EGF-R activation
Source: Annual Congress 2009 - Translational models of lung disease
Year: 2009



Cigarette smoke extract reduces VEGF in primary human airway epithelial cells
Source: Eur Respir J 2009; 33: 835-843
Year: 2009



α,β-unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through MAP kinases activation
Source: Annual Congress 2009 - Airway inflammation and host defence
Year: 2009


Association of IL-17 transcription and neutrophil activation in human airways following organic dust exposure
Source: Eur Respir J 2003; 22: Suppl. 45, 179s
Year: 2003

High amplitude/high frequency mechanical stretch induces nuclear translocation of NFkB in human pulmonary fibroblasts
Source: Eur Respir J 2006; 28: Suppl. 50, 399s
Year: 2006

Transcriptional co-activators (CBP/p300) induced in response to environmental particulates
Source: Eur Respir J 2002; 20: Suppl. 38, 372s
Year: 2002

Bradykinin phosphorylates ERK1/2 through epidermal growth factor receptor transactivation in human lung fibroblasts
Source: Eur Respir J 2005; 26: Suppl. 49, 341s
Year: 2005

Potential role of filamin and p38 MAPK in the regulation of human alveolar epithelial cell permeability
Source: Eur Respir J 2002; 20: Suppl. 38, 96s
Year: 2002

Effect of smoking on MAP kinase-induced modulation of IL-8 in human alveolar macrophages
Source: Eur Respir J 2004; 23: 805-812
Year: 2004



Effect of diesel exposure on markers of apoptosis and proliferation within the bronchial epithelium
Source: Eur Respir J 2004; 24: Suppl. 48, 604s
Year: 2004

Nrf2 is closely related to enhance bleomycin induced airway inflammatory responses caused by diesel exhaust particles in mice
Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation
Year: 2012