Budesonide-induced decrease of IL-5 production does not affect allergen-induced bronchoconstriction or AHR in a novel guinea pig asthma model

P. Ramos Ramirez (Stockholm, Sweden), M. Noreby (Stockholm, Sweden), H. Olsson (Gothenburg, Sweden), G. Nilsson (Stockholm, Sweden), S. Dahlén (Stockholm, Sweden), M. Adner (Stockholm, Sweden)

Source: International Congress 2019 – Novel insights from in vitro and in vivo models of lung disease
Session: Novel insights from in vitro and in vivo models of lung disease
Session type: Thematic Poster
Number: 4081
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
P. Ramos Ramirez (Stockholm, Sweden), M. Noreby (Stockholm, Sweden), H. Olsson (Gothenburg, Sweden), G. Nilsson (Stockholm, Sweden), S. Dahlén (Stockholm, Sweden), M. Adner (Stockholm, Sweden). Budesonide-induced decrease of IL-5 production does not affect allergen-induced bronchoconstriction or AHR in a novel guinea pig asthma model. 4081

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The inflammation and the airway hyperresponsiveness in allergic asthma is inhibited by IL-10 dependent mechanism
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


Protection against allergen-induced airway hyperresponsiveness (AHR) by olodaterol in guinea pigs is synergistically enhanced by tiotropium
Source: Annual Congress 2012 - Animal models of asthma and COPD and late-breaking abstracts on RCT in asthma and COPD
Year: 2012

Effects of IL-4Rα blockade on lung inflammation and airway hyperresponsiveness using Mu317RAXMu, a murine surrogate for AMG 317, in a treatment model of cockroach allergen-induced asthma in mice
Source: Annual Congress 2008 - Novel mechanisms in the pathogenesis of pulmonary inflammation
Year: 2008

Estrogen prevents airway hyperresponsiveness in a murine model of allergic asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 433s
Year: 2006

Obesity enhances allergen-induced airway inflammation in a murine model of asthma
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

Deficiency of MMP-19 promotes allergen-induced eosinophil burden and airway responsiveness in mice
Source: Annual Congress 2007 - Regulation of allergic airway inflammation in animal models of asthma
Year: 2007



MMP-9 deficiency reduces airway inflammation and hyperresponsiveness in a mouse model of asthma
Source: Eur Respir J 2001; 18: Suppl. 33, 20s
Year: 2001

The inhaled PDE4 inhibitor UK-500,001 does not significantly inhibit airway responses to allergen and histamine
Source: Annual Congress 2007 - New drugs for asthma
Year: 2007


Oophorectomy decreases airway responsiveness but not eosinophilia in an ovalbumin sensitization murine model of allergy
Source: Annual Congress 2006 - Cell biology of asthma and COPD
Year: 2006


The development of an airway hyperresponsiveness (AHR) depends on mast cells following sensitization without adjuvant
Source: Annual Congress 2006 - Cellular immunology in asthma pathogenesis
Year: 2006


Dissociation of airway inflammation and hyperresponsiveness by cyclooxygenase inhibition in allergen challenged mice
Source: Eur Respir J 2009; 34: 200-208
Year: 2009



Effects of OVA-induced allergic airway inflammation and remodeling in mice in three distinct asthma models
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010


Estrogen prevents airway inflammation and hyperresponsiveness in a murine model of acute allergic asthma
Source: Eur Respir J 2007; 30: Suppl. 51, 360s
Year: 2007

The effect of Der f-induced airway inflammation on airway inflammation in a murine model of allergic asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 348s
Year: 2004

IPL576,092 reduces allergen-induced late asthmatic responses, sputum eosinophilia and airway hyperresponsiveness in mild asthma
Source: Eur Respir J 2003; 22: Suppl. 45, 104s
Year: 2003

Transgenic mice overexpressing IL-18 display increased IL-13 in the airways but no changes of the airway hyperresponsiveness in a murine model of late-phase asthma: evidence for a dual role of IL-18 on mucosal Th1/Th2 responses
Source: Eur Respir J 2002; 20: Suppl. 38, 1s
Year: 2002

Dissociation of the effects of a steroid on inflammation compared to airway hyperresponsiveness (AHR) in a model of asthma in conscious mice
Source: Eur Respir J 2001; 18: Suppl. 33, 30s
Year: 2001

A fully dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a murine model of asthma
Source: Annual Congress 2010 - Pre-clinical models of airways disease
Year: 2010

The PAR2-activating peptide SLIGRL inhibits airway hyper-responsiveness and eosinophilia in an acute murine model of allergic asthma
Source: Annual Congress 2004 - Animal models of asthma and chronic bronchitis and their relevance in pulmonary pharmacology
Year: 2004


Experimental specific immunotherapy with timpol decreases allergic sensitization and airway inflammation in murine model of bronchial asthma
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010