Calcium-sensing receptor (CaSR) antagonists (calcilytics) prevent urban particulate matter (UPM)-induced dendritic cell activation.

B. Mansfield (Cardiff, United Kingdom), T. Ho (London, United Kingdom), I. Mudway (London, United Kingdom), C. Corrigan (London, United Kingdom), J. Ward (London, United Kingdom), P. Kemp (Cardiff, United Kingdom), K. Lewis (Swansea, United Kingdom), L. Mur (Aberystwyth, United Kingdom), C. Hawrylowicz (London, United Kingdom), D. Riccardi (Cardiff, United Kingdom)

Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
B. Mansfield (Cardiff, United Kingdom), T. Ho (London, United Kingdom), I. Mudway (London, United Kingdom), C. Corrigan (London, United Kingdom), J. Ward (London, United Kingdom), P. Kemp (Cardiff, United Kingdom), K. Lewis (Swansea, United Kingdom), L. Mur (Aberystwyth, United Kingdom), C. Hawrylowicz (London, United Kingdom), D. Riccardi (Cardiff, United Kingdom). Calcium-sensing receptor (CaSR) antagonists (calcilytics) prevent urban particulate matter (UPM)-induced dendritic cell activation.. 2401

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Calcium-sensing receptor antagonists, calcilytics, prevent activation of human dendritic and epithelial cells by urban particulate matter
Source: Virtual Congress 2020 – Effects of environmental exposures on lung pathology
Year: 2020


Nicotinic alpha-7 receptor stimulation (a7nAChR) inhibited NF-kB/STAT3/SOCS3 pathways in a murine model of asthma.
Source: International Congress 2017 – Novel mechanisms and treatments for asthma
Year: 2017



The effect of leukotrienes and their receptor antagonists on calcium signalling in the cough receptors transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1)
Source: Annual Congress 2010 - Models of airways disease
Year: 2010


Mas receptor antagonist inhibits the pro-resolutive effects of Angiotensin-(1-7) in an experimental model of asthma.
Source: International Congress 2019 – Modelling and monitoring of airway diseases
Year: 2019

Expression and role of EGFR ligands induced in airway cells by PM2.5 and its components
Source: Eur Respir J 2007; 30: 1064-1073
Year: 2007



Ethanol (EtOH) causes bronchoconstriction and plasma protein extravasation (PPE) in rodent airways via vanilloid receptor 1 (VR1) activation
Source: Eur Respir J 2002; 20: Suppl. 38, 485s
Year: 2002

Opioid receptors antagonist N-acylstearoilethanolamine (NAE) modulates Th1/Th2 cell function in COPD after radiation exposure
Source: Eur Respir J 2004; 24: Suppl. 48, 133s
Year: 2004

Protease-activated receptor 2 (PAR2) stimulation potentiates citric acid induced cough by sensitising the vanilloid receptor-1 (TRPV1)
Source: Annual Congress 2003 - Novel drugs under development for the treatment of respiratory diseases
Year: 2003


The endocannabinoids anandamide and 2-arachidonyl-glycerol (2-AG) induce pulmonary hypertension (PH) in a CB1 receptor independent manner - role of COX-2 and EP1 receptor activation
Source: Eur Respir J 2005; 26: Suppl. 49, 733s
Year: 2005

Ethanol (EtOH) promotes Ca2+ mobilization and neuropeptide release from airway sensory nerves via vanilloid receptor 1 (VR1) activation
Source: Eur Respir J 2002; 20: Suppl. 38, 170s
Year: 2002

Serotonin (5-hydroxytryptamine) modulates cytokine and chemokine production in lipopolysaccharide-primed human monocytes via stimulation of different 5-HT receptor subtypes
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


Cystenyl-leukotriene receptor antagonist (LRA) inhibits respiratory burst of human neutrophils
Source: Eur Respir J 2003; 22: Suppl. 45, 316s
Year: 2003

Acupuncture regulates macrophage polarization in COPD mice model by activating dopamine D2 receptor.
Source: Virtual Congress 2021 – Airway pharmacology: translational and basic science
Year: 2021

Peroxisome proliferator activated receptor gamma (PPARγ) agonist rosiglitizone inhibits upregulation of mucin gene expression in two airway epithelial cell lines
Source: Eur Respir J 2005; 26: Suppl. 49, 97s
Year: 2005

Ligand independent activation of the glucocorticoid receptor by long acting β2 agonists
Source: Eur Respir J 2004; 24: Suppl. 48, 317s
Year: 2004

Differential toll-like receptor (TLR) responses of primary human alveolar macrophages and type II epithelial (AT2) cells alone and in co-culture
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009

The pro-apoptotic effect of cysteinyl leukotriene receptor (CysLT-R) antagonist montelukast is mediated by CysLT-Rs expression on antigen-stimulated T cells
Source: Eur Respir J 2003; 22: Suppl. 45, 100s
Year: 2003

Different alcohols activate airway sensory nerves by a vanilloid receptor 1 (TRPV1) dependent mechanism
Source: Eur Respir J 2003; 22: Suppl. 45, 415s
Year: 2003

Enhanced platelet activating factor receptor (PAFR) expression in smoker airways
Source: Annual Congress 2011 - Insight into mechanisms of respiratory infections
Year: 2011