Late Breaking Abstract - The neurokinin-1 receptor antagonist orvepitant improves chronic cough symptoms: results from a Phase 2b trial

J. Smith (Manchester, United Kingdom), E. Ballantyne (Stevenage, United Kingdom), M. Kerr (Stevenage, United Kingdom), L. Mcgarvey (Belfast, United Kingdom), A. Morice (Cottingham, United Kingdom), M. Sher (Largo, Florida, United States of America), M. Trower (Stevenage, United Kingdom), S. Pawsey (Stevenage, United Kingdom)

Source: International Congress 2019 – Highlights in lung function and chronic cough
Session: Highlights in lung function and chronic cough
Session type: Poster Discussion
Number: 600
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Smith (Manchester, United Kingdom), E. Ballantyne (Stevenage, United Kingdom), M. Kerr (Stevenage, United Kingdom), L. Mcgarvey (Belfast, United Kingdom), A. Morice (Cottingham, United Kingdom), M. Sher (Largo, Florida, United States of America), M. Trower (Stevenage, United Kingdom), S. Pawsey (Stevenage, United Kingdom). Late Breaking Abstract - The neurokinin-1 receptor antagonist orvepitant improves chronic cough symptoms: results from a Phase 2b trial. 600

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Baseline patient burden in chronic cough from a Phase 2b clinical trial of gefapixant, a P2X3 receptor antagonist
Source: International Congress 2019 – Highlights in lung function and chronic cough
Year: 2019


Characterization of chronic cough patients participating in a phase 2b clinical trial of gefapixant, a P2X3 receptor antagonist
Source: International Congress 2019 – Highlights in lung function and chronic cough
Year: 2019


Design of phase 2b randomised controlled trial of S-600918, P2X3 receptor antagonist for refractory chronic cough
Source: Virtual Congress 2020 – Asthma and cough: clinical trials and pharmacological insights
Year: 2020


Design and rationale of two phase 3 randomised controlled trials (COUGH-1 and COUGH-2) of gefapixant, a P2X3 receptor antagonist, in refractory or unexplained chronic cough
Source: ERJ Open Res, 6 (4) 00284-2020; 10.1183/23120541.00284-2020
Year: 2020



Late Breaking Abstract - Phase 2a randomised, double-blind, placebo-controlled, crossover study of a novel P2X3 receptor antagonist S-600918 in patients with refractory chronic cough
Source: International Congress 2019 – ALERT: Abstracts Leading to Evolution in Respiratory Medicine Trials: COPD and cough
Year: 2019




LATE-BREAKING ABSTRACT: Phase 2a randomized placebo-controlled trial of the oral prostaglandin D2 receptor (DP2/ CRTh2) antagonist QAW039 in eosinophilic asthma
Source: International Congress 2014 – The future has started: emerging potentials for personalised asthma treatment
Year: 2014

An open-label pilot study of memantine, an N-methyl-D-aspartate receptor antagonist in chronic cough
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

Late Breaking Abstract - Efficacy and safety of eliapixant in refractory chronic cough: Results of the PAGANINI 12-week, randomized, placebo-controlled Phase 2b study
Source: Virtual Congress 2021 – Airway pharmacology: translational and basic science
Year: 2021


Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study
Source: Eur Respir J, 58 (5) 2004240; 10.1183/13993003.04240-2020
Year: 2021



Late Breaking Abstract - Masitinib in severe asthma: Results from a randomized, phase 3 trial
Source: Virtual Congress 2020 – ALERT: Asthma in adults and children
Year: 2020




Improvements in cough severity and cough-related quality of life in a phase 2 trial (RELIEF) with the P2X3 antagonist BLU-5937 in refractory chronic cough (RCC)
Source: Virtual Congress 2021 – Clinical trials in airway diseases: novel treatments and new evidence
Year: 2021



Late Breaking Abstract - RPL554, a first-in-class dual PDE3/4 inhibitor, causes significant bronchodilation and symptom relief; a Phase 2b COPD study
Source: International Congress 2018 – Novel drug targets for asthma and COPD
Year: 2018



Late Breaking Abstract: TLR9 agonist CYT003-QbG10 is safe and efficacious in persistent allergic asthma: A double-blind, placebo-controlled phase II study
Source: Annual Congress 2010 - Biomarkers of asthma and COPD: recent advances
Year: 2010

A dual-acting muscarinic antagonist, ß2-agonist [MABA] molecule (GSK961081) improves lung function in COPD. A randomised trial
Source: Annual Congress 2012 - New bronchodilators and other novel drugs for asthma and COPD
Year: 2012

Inhibition of P2X3 by MK-7264 reduces 24-hour cough frequency in a randomized, controlled, Phase 2b clinical trial
Source: International Congress 2017 – New ideas for the management of chronic lung diseases
Year: 2017



Late Breaking Abstract: GRC 17536, a novel, selective TRPA1 antagonist for potential treatment of respiratory disorders
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

Late Breaking Abstract - PK/PD assessment of an oral, selective aVß6/aVß1 integrin dual antagonist, PLN-74809, for the treatment of idiopathic pulmonary fibrosis
Source: International Congress 2019 – Translational aspects of idiopathic interstitial pneumonia
Year: 2019

Late Breaking Abstract - Two Phase 3 Randomized Clinical Trials of Gefapixant, a P2X3 Receptor Antagonist, in Refractory or Unexplained Chronic Cough (COUGH-1 and COUGH-2)
Source: Virtual Congress 2020 – ALERT: Pneumothorax, cough, PAH, alveolar proteinosis
Year: 2020




Late Breaking Abstract - Astegolimab, an anti-ST2, in chronic obstructive pulmonary disease - COPD-ST2OP: a phase IIa, placebo-controlled trial
Source: Virtual Congress 2021 – ALERT: COPD
Year: 2021



Late Breaking Abstract - Efficacy and safety of tezepelumab in adults with severe asthma: A randomized phase 2 study
Source: International Congress 2017 – Late-breaking studies in asthma and COPD
Year: 2017