Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Disease area: Interstitial lung diseases



Rating:

Share or cite this content

Citations should be made in the following way:
I. Ganzleben (Erlangen, Germany), G. He (Erlangen, Germany), C. Günther (Erlangen, Germany), E. Prigge (Heidelberg, Germany), K. Richter (Heidelberg, Germany), R. Rieker (Erlangen, Germany), D. Mougiakakos (Erlangen, Germany), M. Neurath (Erlangen, Germany), C. Becker (Erlangen, Germany). PGAM5 acts as a key mediator of lung fibrosis by disrupting mitochondrial homeostasis. 595

Member's Comments

No comment yet.

Related content which might interest you: SH2 domain-containing Phosphatase-(SHP)-2 blunts fibrotic responses through regulation of fibroblast mitochondrial metabolism and autophagy Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease Year: 2019 MAV(S)erick mitochondria: an unconventional role for mitochondrial antiviral signalling protein in pulmonary fibrosis Source: Eur Respir J, 57 (4) 2004500; 10.1183/13993003.04500-2020 Year: 2021 Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis Source: Eur Respir J, 57 (4) 2000652; 10.1183/13993003.00652-2020 Year: 2021 HIF pathway activation is a core regulator of collagen structure-function in lung fibrosis Source: Virtual Congress 2020 – Lung epithelial development and repair in three-dimensions Year: 2020 The airway microbiota: a key regulator of homeostasis and fibrosis Source: International Congress 2016 – Microbiome in health and in disease Year: 2016 The pathomechanistic role of autophagy in lung fibrosis Source: International Congress 2017 – Interstitial lung diseases (ILDs): novel pathogenetic pathways Year: 2017 Mitochondrial metabolism regulates cellular proteostasis Source: ERS Lung Science Conference 2020 Year: 2020 Chronic WNT/ß-catenin signaling impairs mitochondrial function in lung epithelial cells Source: Virtual Congress 2021 – Cellular and molecular involvement in lung injury and repair Year: 2021 Regulation of alternative macrophage activation by galectin-3; potential role in lung fibrosis Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease? Year: 2009 TRIM33 prevents pulmonary fibrosis by impairing TGF-ß1 signalling Source: Eur Respir J, 55 (6) 1901346; 10.1183/13993003.01346-2019 Year: 2020 Extracellular vesicles and their role in lung homeostasis and disease Source: International Congress 2018 – Cross-talk in the lung microenvironment: implications for chronic lung disease Year: 2018 PTEN deficiency in alveolar type 2 cells accelerates cellular senescence, disrupts epithelial–mesenchymal and mitochondrial homeostasis, and induces age-related emphysema Source: International Congress 2019 – Cellular metabolism and immune senescence in lung pathology Year: 2019 Extracellular HSP90a promotes cellular senescence in pulmonary fibrosis through TGFß signaling Source: Virtual Congress 2020 – Idiopathic pulmonary fibrosis and interstitial lung disease: progression, genes and more Year: 2020 Cigarette-decreased NAD/SIRT1 aggravates pulmonary fibrosis by promoting senescence of alveolar type 2 cells through autophagy inhibition and mitochondrial oxidative stress induction Source: Virtual Congress 2020 – Idiopathic pulmonary fibrosis and interstitial lung disease: progression, genes and more Year: 2020 The role of mitochondrial DAMPs in driving lung inflammation and injury Source: International Congress 2016 – Dysfunctional mitochondria in respiratory disease Year: 2016 ER-stress a link to lung remodelling Source: Annual Congress 2013 –Inflammasomes in lung diseases Year: 2013 PP221 – EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury Source: ERS Lung Science Conference 2021 Year: 2021 miR-146a-5p plays an essential role in the aberrant epithelial–fibroblast cross-talk in COPD Source: Eur Respir J, 49 (5) 1602538; 10.1183/13993003.02538-2016 Year: 2017 Hypoxia mediated alterations and role of cell cytoskeleton in trafficking Source: Lung Science Conference 2006 - Hypoxia in Lung Biology and Disease Year: 2006