Nicotinic alpha-7 receptor stimulation (a7nAChR) inhibited NF-kB/STAT3/SOCS3 pathways in a murine model of asthma. Source: International Congress 2017 – Novel mechanisms and treatments for asthma Year: 2017
A novel receptor antagonist, c-027, inhibits airway contraction in human and murine models of allergen, independent of inflammatory mediator release Source: Annual Congress 2009 - Novel mechanisms in the pathogenesis of asthma Year: 2009
Serotonin (5-hydroxytryptamine) modulates cytokine and chemokine production in lipopolysaccharide-primed human monocytes via stimulation of different 5-HT receptor subtypes Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma Year: 2005
CS-003, a novel triple neurokinin receptor antagonist, inhibits symptoms of respiratory diseases models in guinea pigs Source: Eur Respir J 2006; 28: Suppl. 50, 664s Year: 2006
Enhanced platelet activating factor receptor (PAFR) expression in smoker airways Source: Annual Congress 2011 - Insight into mechanisms of respiratory infections Year: 2011
Mas receptor antagonist inhibits the pro-resolutive effects of Angiotensin-(1-7) in an experimental model of asthma. Source: International Congress 2019 – Modelling and monitoring of airway diseases Year: 2019
The pro-apoptotic effect of cysteinyl leukotriene receptor (CysLT-R) antagonist montelukast is mediated by CysLT-Rs expression on antigen-stimulated T cells Source: Eur Respir J 2003; 22: Suppl. 45, 100s Year: 2003
Inhibition of LPS-induced neutrophil recruitment in the lungs correlates with modulation of neutrophil CD11b expression using the selective CXCR2 receptor antagonist SB-656933 Source: Eur Respir J 2004; 24: Suppl. 48, 218s Year: 2004
Ethanol (EtOH) causes bronchoconstriction and plasma protein extravasation (PPE) in rodent airways via vanilloid receptor 1 (VR1) activation Source: Eur Respir J 2002; 20: Suppl. 38, 485s Year: 2002
The selective CXCR2 receptor antagonist SB-656933 inhibits CXCL1-induced neutrophil CD11b expression in human whole blood Source: Eur Respir J 2004; 24: Suppl. 48, 218s Year: 2004
Zaphirlukast inhibits in vitro the respiratory burst of human neutrophils Source: Eur Respir J 2001; 18: Suppl. 33, 79s Year: 2001
The respiratory burst of human neutrophils is inhibited in vitro by Montelukast Source: Eur Respir J 2002; 20: Suppl. 38, 620s Year: 2002
The inducible kinin B1 receptor stimulates human airway fibroblast (Fb) proliferation Source: Eur Respir J 2004; 24: Suppl. 48, 37s Year: 2004
The cannabinoid receptor agonist, WIN 55,212-2, inhibits antigen-induced plasma extravasation in guinea pig airways Source: Annual Congress 2010 - Models of airways disease Year: 2010
Endothelin receptor B (ETB R) dependent GM-CSF mRNA stabilization explains the higher efficacy of bosentan vs. ambrisentan in the reduction of GM-CSF release from human airway smooth muscle cells (HASMCs) Source: Annual Congress 2011 - Experimental modulation of airway inflammation Year: 2011
Endothelin receptor antagonists (ERAs) neutralize LPS-induced cytokine release from pulmonary vascular smooth muscle cells (PVSMCs) by down-regulation of CD14 Source: Annual Congress 2013 –Airway smooth muscle and cell biology Year: 2013
Liver-X-receptor agonists, but not dexamethasone, inhibit leukotriene production from human white blood cells pretreated with GM-CSF and activated with fMLP Source: Annual Congress 2007 - New treatments for asthma and COPD - experimental evidence Year: 2007
Protease-activated receptor 2 (PAR2) stimulation potentiates citric acid induced cough by sensitising the vanilloid receptor-1 (TRPV1) Source: Annual Congress 2003 - Novel drugs under development for the treatment of respiratory diseases Year: 2003
Modulation of transient receptor potential vanilloid-1 (TRPV1) by inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) is associated with increased cough sensitivity to capsaicin (CPS) and autonomic dysregulation of cardiac rhythm in healthy subjects Source: Virtual Congress 2020 – Occupational and environmental causes of respiratory disease Year: 2020
Suppression of basophil activation via histamine receptor 2 (HR2) Source: Eur Respir J 2005; 26: Suppl. 49, 585s Year: 2005