Roflumilast, a selective phosphodiesterase 4 inhibitor, shows efficacy and safety in the long-term treatment of asthma

E. D. Bateman, J. L. Izquierdo, N. Vetter, C. Schmid-Wirlitsch, D. Bredenbroeker (Cape Town, South Africa; Guadalaljara, Spain; Vienna, Austria; Konstanz, Germany)

Source: Annual Congress 2003 - Newer and alternative non-steroidal treatments for asthmatic inflammation
Session: Newer and alternative non-steroidal treatments for asthmatic inflammation
Session type: Oral Presentation
Number: 1393
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
E. D. Bateman, J. L. Izquierdo, N. Vetter, C. Schmid-Wirlitsch, D. Bredenbroeker (Cape Town, South Africa; Guadalaljara, Spain; Vienna, Austria; Konstanz, Germany). Roflumilast, a selective phosphodiesterase 4 inhibitor, shows efficacy and safety in the long-term treatment of asthma. Eur Respir J 2003; 22: Suppl. 45, 1393

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, is effective in the treatment of asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 303s
Year: 2002

Efficacy and safety of four doses of CHF6001, a novel inhaled phosphodiesterase-4 inhibitor (PDE4i), in patients with moderate-to-severe COPD
Source: International Congress 2019 – COPD clinical trials: new molecules and novel insights
Year: 2019



The novel selective PDE4 inhibitor roflumilast: early onset of efficacy in asthma
Source: Eur Respir J 2003; 22: Suppl. 45, 203s
Year: 2003

Roflumilast, an oral, once-daily PDE4 inhibitor, improves lung function and reduces exacerbation rates in patients with COPD
Source: Eur Respir J 2004; 24: Suppl. 48, 21s
Year: 2004

The short-term bronchodilator effects of the dual phosphodiesterase 3 and 4 inhibitor RPL554 in COPD
Source: Eur Respir J, 52 (5) 1801074; 10.1183/13993003.01074-2018
Year: 2018



Smoking has no effect on the pharmacokinetics of roflumilast, a new, orally active, selective PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Dose-dependent inhibitory effect of Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, on allergen-induced early and late asthmatic reaction
Source: Eur Respir J 2002; 20: Suppl. 38, 110s
Year: 2002

Roflumilast, a new, orally active, selective PDE4 inhibitor, does not interact with inhaled budesonide
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Roflumilast, a PDE4 inhibitor, improves lung function in patients with COPD treated with tiotropium
Source: Annual Congress 2009 - Treatment of COPD
Year: 2009

No interaction of roflumilast, a new, orally active, selective PDE4 inhibitor, with inhaled salbutamol
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, is safe and well tolerated in patients with chronic obstructive pulmonary disease
Source: Eur Respir J 2002; 20: Suppl. 38, 303s
Year: 2002

The bronchodilatory and anti-inflammatory effect of MT-810, a novel selective phosphodiesterase-4 (PDE4) inhibitor
Source: Eur Respir J 2006; 28: Suppl. 50, 434s
Year: 2006

Cilomilast, a potent, selective inhibitor of phosphodiesterase 4, improves small airway function in patients with chronic obstructive pulmonary disease: results of a 6-month trial
Source: Eur Respir J 2001; 18: Suppl. 33, 94s
Year: 2001

The in vivo activity of AWD 12-353, a potent phosphodiesterase 4 (PDE) inhibitor for the treatment of allergic asthma and COPD
Source: Eur Respir J 2003; 22: Suppl. 45, 107s
Year: 2003

Safety, tolerability and pharmacokinetics of a new inhaled once-daily phosphodiesterase (PDE) 4 inhibitor in healthy volunteers
Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine
Year: 2013

Comparison of roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, with beclomethasone dipropionate in asthma control
Source: Eur Respir J 2002; 20: Suppl. 38, 304s
Year: 2002

Roflumilast, a new orally active phosphodiesterase 4 inhibitor, is effective in the treatment of chronic obstructive pulmonary disease
Source: Eur Respir J 2002; 20: Suppl. 38, 374s
Year: 2002

Ensifentrine, a novel dual phosphodiesterase (PDE) 3 and 4 inhibitor, provides effective bronchodilation when administered by dry powder inhaler in COPD
Source: International Congress 2019 – COPD clinical trials: new molecules and novel insights
Year: 2019




A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD
Source: Eur Respir J 2009; 33: 1039-1044
Year: 2009



A long-term (2 years) efficacy and safety study of doxofylline in the treatment of asthma
Source: International Congress 2019 – Clinical studies of asthma treatments
Year: 2019