Fine structural modifications of heparan sulfate sulfation patterns in lung are associated with functional effects in Precapillary Pulmonary Hypertension

P. ALBANESE (Creteil, France), S. Dumas (Le Plessis Robinson, France), B. Ranchoux (Le Plessis Robinson, France), S. Shamdani (Creteil, France), S. Chantepie (Creteil, France), M. Huynh (Creteil, France), D. Montani (Le Kremlin Bicetre, France), B. Girerd (Le Kremlin Bicetre, France), P. Dorfmuller (Le Plessis Robinson, France), E. Fadel (Le Plessis Robinson, France), P. Dartevelle (Le Plessis Robinson, France), F. Perros (Le Plessis Robinson, France), M. Humbert (Le Kremlin Bicetre, France), D. Papy-Garcia (Creteil, France), S. Cohen-Kaminsky (Le Plessis Robinson, France)

Source: International Congress 2018 – Pathobiology of pulmonary hypertension
Session: Pathobiology of pulmonary hypertension
Session type: Poster Discussion
Number: 3936
Disease area: Pulmonary vascular diseases

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
P. ALBANESE (Creteil, France), S. Dumas (Le Plessis Robinson, France), B. Ranchoux (Le Plessis Robinson, France), S. Shamdani (Creteil, France), S. Chantepie (Creteil, France), M. Huynh (Creteil, France), D. Montani (Le Kremlin Bicetre, France), B. Girerd (Le Kremlin Bicetre, France), P. Dorfmuller (Le Plessis Robinson, France), E. Fadel (Le Plessis Robinson, France), P. Dartevelle (Le Plessis Robinson, France), F. Perros (Le Plessis Robinson, France), M. Humbert (Le Kremlin Bicetre, France), D. Papy-Garcia (Creteil, France), S. Cohen-Kaminsky (Le Plessis Robinson, France). Fine structural modifications of heparan sulfate sulfation patterns in lung are associated with functional effects in Precapillary Pulmonary Hypertension. 3936

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Alterations in the expression of proteoglycans and glycosaminoglycans in pulmonary hypertension
Source: Eur Respir J 2006; 28: Suppl. 50, 659s
Year: 2006

Lung heparan and chondroitine sulfate imbalance and functional changes in pulmonary hypertension
Source: International Congress 2014 – Pulmonary hypertension: pathobiology
Year: 2014

Diaphragm dysfunction in chronic obstructive pulmonary disease: a role for heparan sulphate?
Source: Eur Respir J 2007; 30: 80-89
Year: 2007



Perlecan and heparan sulphate are abundant in fibroblast foci in Idiopathic Pulmonary Fibrosis.
Source: International Congress 2017 – Novel pro- and anti-fibrotic mechanisms in pulmonary fibrosis
Year: 2017

Analysis of pulmonary endothelial microparticles, haemodynamics and functional class in pulmonary hypertension
Source: International Congress 2015 – Pulmonary hypertension: novel insights into the biology of the disease
Year: 2015

Hyaluronic acid, heparan sulfate and chondroitin sulfate are altered during exacerbations of COPD
Source: International Congress 2017 – Infection and exacerbation science
Year: 2017

The myofibroblast in pulmonary fibrosis displays distinct functional characteristics, depending on its source of origin
Source: International Congress 2014 – ILDs 3
Year: 2014

Analysis of miRNA profile in circulating microparticles of patients with pulmonary arterial hypertension
Source: International Congress 2015 – Pulmonary hypertension: rare and hereditary causes of PAH
Year: 2015

Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease
Source: Eur Respir J 2016; 48: 1215-1218
Year: 2016


Altered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis
Source: International Congress 2017 – Rare diseases
Year: 2017


Elevated protein arginine methyltransferase 1 expression contributes to the pathogenesis of pulmonary fibrosis
Source: International Congress 2014 – ILDs: pathogenesis and clinical features
Year: 2014

Functional and molecular disparities between mesenchymal stem cells from various pulmonary disorders
Source: International Congress 2014 – Pulmonary fibrosis: receptors, signalling pathways and mesenchymal cells
Year: 2014



Differential expression of tenascin C splice variants in endobronchial epithelial-lining fluid in proximity of pulmonary nodules
Source: Annual Congress 2013 –Translational research to bridge the need within clinical decision making
Year: 2013

Predictors for significant changes in serum sulfated glycosaminoglycans at COPD exacerbations
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

Functional characterization of BMPR2 gene in pulmonary arterial hypertension
Source: International Congress 2015 – Pulmonary hypertension: rare and hereditary causes of PAH
Year: 2015

LATE-BREAKING ABSTRACT: The bromodomain-containing protein 4: the epigenetic origin of the oncogenic signature in pulmonary hypertension
Source: International Congress 2014 – New technologies and biomarkers in lung disease
Year: 2014

Age-dependent systemic elastin degradation is enhanced in chronic obstructive pulmonary disease
Source: International Congress 2016 – New signalling pathways in COPD
Year: 2016


Adventitial remodeling of experimental pulmonary hypertension induces myofibroblast-produced collagen V in a Th17-pathways-related manner
Source: International Congress 2016 – Pulmonary hypertension: novel insights
Year: 2016


Pulmonary arterial lesions and interstitial remodeling patterns in histology differentiate EIF2AK4 mutation-carriers from non-carriers with pulmonary veno-occlusive disease
Source: International Congress 2015 – Pulmonary hypertension: rare and hereditary causes of PAH
Year: 2015


Mutational and epigenetic analysis of the promoter region of BMPR2 gene in patients with pulmonary arterial hypertension
Source: International Congress 2014 – Pulmonary hypertension: pathobiology
Year: 2014