A novel piperidine attenuates pulmonary arterial hypertension via regulating BMP2 and PTGS2 levels

Y. Xing (Beijing, China), F. Zhou (Beijing, China), X. Zhao (Beijing, China), R. Al-Lamki (Cambridge, United Kingdom), M. Du (Beijing, China), G. Shang (Nanjing, China), N. Morrell (Cambridge, United Kingdom), J. YANG (Beijing, China)

Source: International Congress 2018 – Pathobiology of pulmonary hypertension
Session: Pathobiology of pulmonary hypertension
Session type: Poster Discussion
Number: 3928
Disease area: Pulmonary vascular diseases

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Y. Xing (Beijing, China), F. Zhou (Beijing, China), X. Zhao (Beijing, China), R. Al-Lamki (Cambridge, United Kingdom), M. Du (Beijing, China), G. Shang (Nanjing, China), N. Morrell (Cambridge, United Kingdom), J. YANG (Beijing, China). A novel piperidine attenuates pulmonary arterial hypertension via regulating BMP2 and PTGS2 levels. 3928

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels
Source: Eur Respir J, 51 (4) 1702229; 10.1183/13993003.02229-2017
Year: 2018



Macitentan modulates pulmonary mRNA levels of gremlin 1 in a rat model of pulmonary arterial hypertension
Source: International Congress 2019 – Pulmonary hypertension with lung diseases and experimental pulmonary hypertension
Year: 2019

Interleukin-13-dependent regulation of endothelin-1 expression in pulmonary arterial hypertension
Source: Annual Congress 2007 - Pulmonary hypertension
Year: 2007


Shroom expression is attenuated in hypoxia-induced pulmonary hypertension
Source: Eur Respir J 2006; 28: Suppl. 50, 147s
Year: 2006

TrkB expression is altered in hypoxia-induced pulmonary hypertension
Source: Eur Respir J 2007; 30: Suppl. 51, 606s
Year: 2007

Pharmacological activation of Nur77 enhances BMP signalling and inhibits vascular remodelling in pulmonary arterial hypertension
Source: International Congress 2018 – Pathobiology of pulmonary hypertension
Year: 2018



The pathophysiological role of novel pulmonary arterial hypertension gene SOX17
Source: Eur Respir J, 58 (3) 2004172; 10.1183/13993003.04172-2020
Year: 2021



Decreased expression of the TGF-beta type I receptor ALK1 in pulmonary arterial hypertension
Source: Annual Congress 2007 - Cellular and molecular aspects of pulmonary hypertension
Year: 2007


TSC1/mTOR pathway promotes hypoxia-induced pulmonary hypertension in mice
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012


Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension
Source: Eur Respir J 2016; 48: 1137-1149
Year: 2016



HDAC inhibitor quisinostat reduces pulmonary vascular remodeling in experimentally induced pulmonary arterial hypertension
Source: Virtual Congress 2020 – Pathophysiology of pulmonary hypertension
Year: 2020


Functional upregulation of PRMT2 in chronic hypoxia-induced pulmonary hypertension
Source: Eur Respir J 2004; 24: Suppl. 48, 721s
Year: 2004

Spermine promotes pulmonary vascular remodelling and its synthase is a therapeutic target for pulmonary arterial hypertension
Source: Eur Respir J, 56 (5) 2000522; 10.1183/13993003.00522-2020
Year: 2020



Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension
Source: Eur Respir J, 54 (6) 1900378; 10.1183/13993003.00378-2019
Year: 2019



Targeted gene delivery of BMPR2 attenuates pulmonary hypertension
Source: Eur Respir J 2012; 39: 329-343
Year: 2012



Survivin inhibition as a potential target for pulmonary arterial hypertension
Source: International Congress 2019 – Pulmonary hypertension: novelties from the bench
Year: 2019

Hypoxia-induced miR-130a is a novel repressor of BMPR2 gene expression in experimental pulmonary hypertension
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms
Year: 2012


NMDA receptor activation promotes vascular remodeling and pulmonary arterial hypertension
Source: International Congress 2018 – Pathobiology of pulmonary hypertension
Year: 2018

ACE2 activation improves pulmonary endothelial function and attenuates monocrotaline-induced pulmonary hypertension
Source: Annual Congress 2011 - Treatment of human pulmonary hypertension
Year: 2011