Extracellular vesicles derived from mesenchymal stem cells prevent pulmonary vascular dysfunction induced by lipopolysaccharide (LPS).

S. Esquivel-Ruiz (Madrid, Spain), B. Barreira (Madrid, Spain), M. Alvárez-Fuente (Madrid, Spain), A. Gurjian (Madrid, Spain), P. Hernández-Hernández (Madrid, Spain), Á. González-Murillo (Madrid, Spain), M. Ramírez-Orellana (Madrid, Spain), M. Del Cerro (Madrid, Spain), Á. Cogolludo (Madrid, Spain), F. Pérez-Vizcaíno (Madrid, Spain), L. Moreno (Madrid, Spain)

Source: International Congress 2018 – Experimental research in pulmonary hypertension
Session: Experimental research in pulmonary hypertension
Session type: Thematic Poster
Number: 3056
Disease area: Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Esquivel-Ruiz (Madrid, Spain), B. Barreira (Madrid, Spain), M. Alvárez-Fuente (Madrid, Spain), A. Gurjian (Madrid, Spain), P. Hernández-Hernández (Madrid, Spain), Á. González-Murillo (Madrid, Spain), M. Ramírez-Orellana (Madrid, Spain), M. Del Cerro (Madrid, Spain), Á. Cogolludo (Madrid, Spain), F. Pérez-Vizcaíno (Madrid, Spain), L. Moreno (Madrid, Spain). Extracellular vesicles derived from mesenchymal stem cells prevent pulmonary vascular dysfunction induced by lipopolysaccharide (LPS).. 3056

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Adrenaline stimulated mesenchymal stem cells modulate inflammation in lipopolysaccharide induced lung injury
Source: Annual Congress 2012 - Stem cells and progenitors in injury and repair
Year: 2012


Secreted mediators from induced pluripotent stem cells (iPSc) attenuate fibrosis in bleomycin injured rat lung
Source: Annual Congress 2012 - Stem cells and progenitors in injury and repair
Year: 2012

Lipopolysaccharide (LPS) treatment enhances the regenerative capacity of mesenchymal stromal cells-derived exosomes
Source: Virtual Congress 2021 – Molecular pathology and cell biology of pulmonary diseases
Year: 2021


Inflammatory response and epithelial-mesenchymal transition based on the model of co-cultured alveolar epithelial cells and monocytes induced by lipopolysaccharide.
Source: International Congress 2017 – Current molecular and genetic understanding of lung diseases
Year: 2017

Primary bronchial epithelial cells from stable lung allografts induce the differentiation of monocytes into macrophage like cells
Source: Annual Congress 2008 - New insights and treatment options for bronchiolitis obliterans syndrome after lung transplantation
Year: 2008

Protective effect of mesenchymal stem cells (MSC) on hypoxia-induced epithelial-mesenchymal transition of alveolar epithelial cells (AEC)
Source: Annual Congress 2012 - Lung injury and repair: reactive oxygen species and beyond
Year: 2012

Mitochondria related hormone stanniocalcin-1 (STC-1) derived from human multipotent stromal cells (MSCs) reduce cell death of human lung epithelial cell line (A549) under fetal acidosis and/or hypoxia
Source: Annual Congress 2008 - Regulatory mechanisms of cell activation, renewal and recruitment
Year: 2008

LSC - 2021 - Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids
Source: Virtual Congress 2021 – In vitro modelling of lung disease: reach out to the next dimension
Year: 2021


Protective roles of paracrine factors of bone marrow mesenchymal stem cells in bleomycin induced lung epithelial cell injury in vitro and pulmonary fibrosis in vivo
Source: Annual Congress 2010 - Experimental approaches in pulmonary fibrosis
Year: 2010


IL-11 promotes pulmonary vascular remodeling and lung fibrosis through the activation of endothelial to mesenchymal transition.
Source: Virtual Congress 2020 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2020

Mesenchymal stromal cells (MSC) anti-microbial effect in acute respiratory distress syndrome (ARDS) is mediated in part by enhanced alveolar macrophage phagocytosis through cell contact-dependent mitochondrial transfer leading to improved macrophage bioenergetics
Source: International Congress 2016 – Novel insights into alveolar and bronchial epithelial cell injury and repair
Year: 2016


Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells
Source: International Congress 2015 – Pulmonary hypertension: promising small molecules
Year: 2015

Mast cells and macrophages affect homeostasis of pulmonary endothelial cells in a spheroidal cell culture model
Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension
Year: 2010

Epithelial fibroblast triggering and interactions in pulmonary fibrosis
Source: Eur Respir Rev 2008; 17: 123-129
Year: 2008



The enhancement of Stanniocalcin-1 (STC1) secretion increases the ability of mesenchymal stem cells (MSCs) to reduce bleomycin-induced lung fibrosis in a mouse model through inhibition of endoplasmic reticulum stress (ER-stress)/TGFbeta1 pathway
Source: International Congress 2014 – ILDs 1
Year: 2014


PP206 – Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids
Source: ERS Lung Science Conference 2021
Year: 2021

Hyperoxia reversibly inhibits the transdifferentiation of alveolar type II (ATII) cells to alveolar type I (ATI) cells
Source: Annual Congress 2005 - Cellular and molecular approaches to lung injury research
Year: 2005


Human mesenchymal stem cell exosomes attenuate inflammation of lung epithelial cells through miR-223 in acute lung injury
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

Therapeutic benefits of exosomes derived from mesenchymal stromal cells in bleomycin-induced pulmonary fibrosis in aged mice.
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017

Distinct patterns of circulating endothelial cells in pulmonary hypertension
Source: Eur Respir J 2010; 36: 1284-1293
Year: 2010