Blocking beta adrenergic signaling may be a target for overcoming EGFR TKI resistance.

E. Heo (Seoul, Republic of Korea), M. Lee (Seoul, Republic of Korea), J. Lee (Seoul, Republic of Korea), D. Kim (Seoul, Republic of Korea), H. Chung (Seoul, Republic of Korea)

Source: International Congress 2018 – Lung cancer: from the bench to the bedside
Session: Lung cancer: from the bench to the bedside
Session type: Thematic Poster
Number: 2854
Disease area: Thoracic oncology

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
E. Heo (Seoul, Republic of Korea), M. Lee (Seoul, Republic of Korea), J. Lee (Seoul, Republic of Korea), D. Kim (Seoul, Republic of Korea), H. Chung (Seoul, Republic of Korea). Blocking beta adrenergic signaling may be a target for overcoming EGFR TKI resistance.. 2854

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Targeting STAT3 pathway signalling in EGFR TKI resistant NSCLC
Source: Virtual Congress 2020 – Chronic lung diseases: novel methods, diagnostics and biomarkers
Year: 2020


Reduction of drug resistance through calcium control in epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) resistant lung cancer cells
Source: Virtual Congress 2020 – Molecular alterations and immunology in lung cancer
Year: 2020


Use of multitarget tyrosine kinase inhibitors to attenuate platelet-derived growth factor signalling in lung disease
Source: Eur Respir Rev, 26 (146) 170061; 10.1183/16000617.0061-2017
Year: 2017



The upregulation of Osteopontin mediates acquired resistance to EGFR-TKI in NSCLC through Integrin/FAK signaling
Source: Virtual Congress 2020 – Biological mechanisms of lung cancer
Year: 2020

Synergistic anti-tumor effects of vandetanib, an inhibitor of VEGFR and EGFR tyrosine kinase inhibitor, combined with cytotoxic agents in lung cancer cell lines
Source: Annual Congress 2010 - Treatment of lung cancer
Year: 2010

Targeted therapy in nonsmall cell lung cancer
Source: Eur Respir Mon; 2009: 44: 284–298
Year: 2009

SiRNA mediated growth factor receptors inhibition in A549 cell model of lung cancer gene therapy: insulin-like growth factor-I receptor (IGF-R1) blockade produces changes that potentially induce anti-tumor immunity
Source: Annual Congress 2008 - Biology in thoracic tumours
Year: 2008


Epidermal growth factor receptor (EGFR) gene mutation testing prior to tyrosine kinase inhibitors (TKI) treatment – prospective data from the Czech TULUNG registry
Source: Virtual Congress 2020 – Real-world data and registries of thoracic oncology
Year: 2020


Transmission of muscarinic receptor mediated proliferative effects in human lung fibroblasts involves ERK-MAP kinase, but not PI-3 kinase and Rho-kinase pathway
Source: Annual Congress 2007 - Miscellaneous pulmonary pharmacology
Year: 2007


Protease activated receptor-1 (PAR-1) stimulation leads to αvβ6 integrin mediated TGFβ activation via rho kinase
Source: Eur Respir J 2005; 26: Suppl. 49, 238s
Year: 2005

Overcome the EGFR-TKIs resistance with cucurbitacin BE compound by targeting STAT3, ERK1/2 and AKT
Source: Annual Congress 2012 - New insights in the pathology of lung cancer
Year: 2012

Safety and efficacy of an inhaled epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (BIBW 2948) in COPD
Source: Annual Congress 2009 - New drugs for airways disease
Year: 2009

EGFR-TKI and lung adenocarcinoma with CNS relapse: interest of molecular follow-up
Source: Eur Respir J 2009; 33: 436-440
Year: 2009



Inhibition of VEGF blocks TGF-β1 production through a PI3K/Akt signalling pathway
Source: Eur Respir J 2008; 31: 523-531
Year: 2008



Mutations of EGFR and k-ras genes and TK inhibitors. Are there differences between gefitinib and erlotinib?
Source: Annual Congress 2008 - Therapy of thoracic tumours
Year: 2008


G-protein mediated EGFR transactivation induces mucin production
Source: Annual Congress 2003 - Cellular and molecular mechanisms in epithelium injury and repair
Year: 2003


Understanding the mechanisms of TKIs: the cycle of inhibition and resistance
Source: International Congress 2016 – The future of tyrosin kinase inhibitors
Year: 2016


Glucocorticoids promote TGF-β signalling in lung fibroblasts by upregulating ligand and receptor expression, and uncoupling negative-feedback inhibition
Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases
Year: 2010

Novel anti-angiogenic pharmacotherapy strategies
Source: Annual Congress 2005 - Update on the role of angiogenesis in the pathogenesis and treatment of lung diseases
Year: 2005

Nomogram to predict the presence of EGFR activating mutation in lung adenocarcinoma
Source: Eur Respir J 2012; 39: 366-372
Year: 2012