Three-dimensional lung epithelial cells potentiate aminoglycoside efficacy by enhancing intracellular pH in Pseudomonas aeruginosa

A. Crabbé (Ghent, Belgium), L. Ostyn (Ghent, Belgium), C. Rigauts (Ghent, Belgium), H. Van Acker (Ghent, Belgium), M. Risseeuw (Ghent, Belgium), S. Van Calenbergh (Ghent, Belgium), T. Coenye (Ghent, Belgium)

Source: International Congress 2018 – Mechanisms of respiratory infection
Session: Mechanisms of respiratory infection
Session type: Thematic Poster
Number: 2644
Disease area: Respiratory infections

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Crabbé (Ghent, Belgium), L. Ostyn (Ghent, Belgium), C. Rigauts (Ghent, Belgium), H. Van Acker (Ghent, Belgium), M. Risseeuw (Ghent, Belgium), S. Van Calenbergh (Ghent, Belgium), T. Coenye (Ghent, Belgium). Three-dimensional lung epithelial cells potentiate aminoglycoside efficacy by enhancing intracellular pH in Pseudomonas aeruginosa. 2644

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Azithromycin protects bronchial epithelial integrity after Pseudomonas aeruginosa infection independent of bactericidal activity
Source: Annual Congress 2008 - Best of lung epithelial cells 2008
Year: 2008



Effects of erythromycin on Pseudomonas aeruginosa adherence to collagen and morphology in vitro
Source: Eur Respir J 2003; 21: 401-406
Year: 2003



Pseudomonas aeruginosa flagellin modulates the immune response in ex vivo lung tissue slices
Source: International Congress 2019 – Mechanisms underlying respiratory infection
Year: 2019

Exploring the susceptibility of P. aeruginosa biofilms in human mucus towards tobramycin treatment
Source: International Congress 2017 – Cystic fibrosis: clinical issues
Year: 2017

The role of efflux pump systems and OprD porine in antimicrobial resistance of Pseudomonas aeruginosa strains isolated from patients with bronchiectasis
Source: Virtual Congress 2021 – Back to infection basics
Year: 2021


Biofilm production and adherence to airway epithelial cells of P. aeruginosa strains: effect of N-acetyl-cysteine
Source: Eur Respir J 2005; 26: Suppl. 49, 726s
Year: 2005

In vitro activity of colistin in combination with N-acetylcysteine against Pseudomonas aeruginosa
Source: International Congress 2018 – Cystic fibrosis in paediatric patients: current research
Year: 2018

Streptococcus pneumoniae inhibits Pseudomonas aeruginosa growth on nasal human epithelium in vitro
Source: International Congress 2018 – New therapies for respiratory infections: experimental and translational studies
Year: 2018

Human airway epithelial cell response to Pseudomonas aeruginosa virulence factors preceded or not by Staphylococcus aureus
Source: Eur Respir J 2006; 28: Suppl. 50, 191s
Year: 2006

Effects of direct lung dosing of Tobramycin in a rat chronic infection model using Pseudomonas aeruginosa RP73
Source: International Congress 2018 – Mechanisms of respiratory infection
Year: 2018


Pseudomonas aeruginosa LasB subverts innate immunity in alveolar macrophages and epithelial cells
Source: International Congress 2018 – Disease exacerbations from a molecular point of view
Year: 2018

Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in vivo
Source: Virtual Congress 2021 – Back to infection basics
Year: 2021

Pseudomonas aeruginosa influences the inflammatory response of primary bronchial epithelial cells to rhinovirus infection
Source: Virtual Congress 2020 – Advances in cystic fibrosis: from microbiome to MRI
Year: 2020



Deleterious impact of Pseudomonas aeruginosa on cystic fibrosis transmembrane conductance regulator function and rescue in airway epithelial cells
Source: Eur Respir J 2015; 45: 1590-1602
Year: 2015



ExoU-induced procoagulant activity in Pseudomonas aeruginosa-infected airway cells
Source: Eur Respir J 2008; 32: 1591-1598
Year: 2008



Intracellular accumulation and bactericidal activity of moxifloxacin and ciprofloxacin in primary respiratory epithelial cells
Source: Eur Respir J 2002; 20: Suppl. 38, 91s
Year: 2002

Characterization of the resistance mechanisms to carbapenems and virulence genes in Pseudomonas aeruginosa strains from children with cystic fibrosis.
Source: Virtual Congress 2021 – Cystic fibrosis in children: various aspects
Year: 2021


Adherence of Pseudomonas aeruginosa to cystic fibrosis buccal epithelial cells
Source: ERJ Open Res, 3 (1) 00095-2016; 10.1183/23120541.00095-2016
Year: 2017



Mechanisms of induction of neutrophil apoptosis by the pseudomonas aeruginosa exotoxin pyocyanin
Source: Eur Respir J 2004; 24: Suppl. 48, 107s
Year: 2004

Chronic Pseudomonas aeruginosa lung infection, but not CFTR modulator therapy affects circulating regulatory T cells in an adult population with cystic fibrosis
Source: Virtual Congress 2021 – Adult cystic fibrosis
Year: 2021