Eosinophils as a predictor of mepolizumab treatment responses in COPD

I. Pavord (Oxford, United Kingdom), G. Criner (Philadelphia, PA, United States of America), H. Kerstjens (Groningen, Netherlands), E. Bradford (Research Triangle Park, NC, United States of America), S. Schweiker Harris (Research Triangle Park, NC, United States of America), O. Keene (Stockley Park West, Uxbridge, Middlesex, United Kingdom), B. Mayer (Stockley Park West, Uxbridge, Middlesex, United Kingdom), D. Rubin (Stockley Park West. Uxbridge, Middlesex, United Kingdom), S. Yancey (Research Triangle Park, NC, United States of America), D. Bratton (Stockley Park, Uxbridge, Middlesex, United Kingdom)

Source: International Congress 2018 – Integrating pharmacological and non-pharmacological management in COPD: are we there yet?
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentationE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
I. Pavord (Oxford, United Kingdom), G. Criner (Philadelphia, PA, United States of America), H. Kerstjens (Groningen, Netherlands), E. Bradford (Research Triangle Park, NC, United States of America), S. Schweiker Harris (Research Triangle Park, NC, United States of America), O. Keene (Stockley Park West, Uxbridge, Middlesex, United Kingdom), B. Mayer (Stockley Park West, Uxbridge, Middlesex, United Kingdom), D. Rubin (Stockley Park West. Uxbridge, Middlesex, United Kingdom), S. Yancey (Research Triangle Park, NC, United States of America), D. Bratton (Stockley Park, Uxbridge, Middlesex, United Kingdom). Eosinophils as a predictor of mepolizumab treatment responses in COPD. 1992

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Evaluation of therapeutic response to anti-IL5 treatment in severe eosinophilic asthma patients no responders to omalizumab
Source: International Congress 2019 – Treatment of asthma with monoclonal antibodies
Year: 2019


Pharmacodynamic effect of benralizumab on blood basophils and serum biomarkers in adults with COPD with sputum eosinophilia
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

Exacerbations of severe asthma in patients treated with mepolizumab
Source: Eur Respir J, 52 (6) 1801127; 10.1183/13993003.01127-2018
Year: 2018



Increase in systemic IL-5 is associated with mepolizumab treatment failure in patients with severe asthma
Source: International Congress 2018 – Role of IgE and interleukin (IL)-5 in Th2-cell signatures
Year: 2018

Clinical response to mepolizumab in patients with severe eosinophilic asthma
Source: International Congress 2019 – Understanding, monitoring and targeting severe asthma
Year: 2019


Eosinophil counts as a predictor of future COPD exacerbations in the DYNAGITO trial
Source: International Congress 2019 – Eosinophils and FeNO in airway diseases
Year: 2019




Plasma biomarkers and response to therapy at exacerbation of COPD
Source: Eur Respir J 2007; 30: Suppl. 51, 39s
Year: 2007

Change in blood eosinophils following treatment with inhaled corticosteroids may predict long-term clinical response in COPD
Source: Eur Respir J, 55 (5) 1902119; 10.1183/13993003.02119-2019
Year: 2020



Endotypes of severe allergic asthma patients who clinically benefit from Anti-IgE therapy
Source: International Congress 2018 – Studying novel biomarkers in asthma and COPD
Year: 2018


The effect of anti-IL-5 therapy on sputum cells and cytokines in asthmatics
Source: International Congress 2019 – Treatment of asthma with monoclonal antibodies
Year: 2019


Does adherence to ICS/LABA therapy affect response to mepolizumab in the treatment of severe asthma?
Source: International Congress 2019 – Real-world experience of monoclonal antibodies in asthma
Year: 2019

Clinically important deteriorations in COPD as a measure of response to dual and mono bronchodilator therapy with and without inhaled corticosteroids
Source: International Congress 2015 – New data on established treatments for COPD
Year: 2015


Real-life treatment of severe eosinophilic asthma with mepolizumab
Source: International Congress 2019 – Real-world experience of monoclonal antibodies in asthma
Year: 2019


Blood eosinophils as a marker of response to inhaled corticosteroids in COPD
Source: Eur Respir J 2016; 47:1374-1382
Year: 2016



Neutrophils and spirometry changes in COPD patients treated with roflumilast
Source: International Congress 2015 – Non-exhaled biomarkers in the assessment of airways disease
Year: 2015

Assessing bronchodilator response in patients with asthma and COPD using 19F-MRI
Source: Virtual Congress 2020 – New imaging techniques applied to old problems
Year: 2020


Cytokines concentrations in induced sputum of mild COPD patients. Correlation to clinical response to inhaled corticosteroids
Source: Eur Respir J 2002; 20: Suppl. 38, 309s
Year: 2002

Th2 related biomarkers as predictors of airway eosinophilia in optimally treated smoking asthmatics: An observational study.
Source: International Congress 2017 – Techniques in biomarker selection
Year: 2017


Adherence to corticosteroids and clinical outcomes in mepolizumab therapy for severe asthma
Source: Eur Respir J, 55 (5) 1902259; 10.1183/13993003.02259-2019
Year: 2020



Depletion rate of blood eosinophils with mepolizumab, benralizumab and oral prednisolone in patients with severe asthma
Source: Virtual Congress 2020 – Monoclonal antibodies; randomised controlled trials and real-world studies in asthma
Year: 2020