Effect of piclamilast, a selective phosphodiesterase (IV)-inhibitor, theophylline and prednisolone, on sputum cell and blood neutrophil oxidative burst from mild asthmatics
K. M. Beeh, J. Beier, A. K. Schulz, C. Lerch, R. Buhl (Mainz, Germany)
Source: Annual Congress 2003 - Fundamental research in developing new drugs
Session: Fundamental research in developing new drugs
Session type: Thematic Poster Session
Number: 740
Disease area: Airway diseases
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
K. M. Beeh, J. Beier, A. K. Schulz, C. Lerch, R. Buhl (Mainz, Germany). Effect of piclamilast, a selective phosphodiesterase (IV)-inhibitor, theophylline and prednisolone, on sputum cell and blood neutrophil oxidative burst from mild asthmatics. Eur Respir J 2003; 22: Suppl. 45, 740
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
The effects of inhaled steroids, leukotriene receptor antagonists and theophylline on induced sputum cell counts, serum and sputum ECP levels in mild persistent asthma Source: Eur Respir J 2001; 18: Suppl. 33, 261s Year: 2001
Synergistic inhibition of oxidative burst in human eosinophils by combination treatment with formoterol and budesonide Source: Eur Respir J 2001; 18: Suppl. 33, 48s Year: 2001
A leukotriene antagonist, montelukast, reduces in vitro LTD4 increases in peripheral blood eosinophil progenitor colonies in atopic subjects Source: Eur Respir J 2001; 18: Suppl. 33, 531s Year: 2001
COPD sputum eosinophils: relationship to blood eosinophils and the effect of inhaled PDE4 inhibition Source: Eur Respir J, 56 (2) 2000237; 10.1183/13993003.00237-2020 Year: 2020
Formoterol is more potent and more effective than salmeterol in the inhibition of oxidative burst in human eosinophils Source: Eur Respir J 2001; 18: Suppl. 33, 49s Year: 2001
Oxidative stress-induced corticosteroid insensitivity is reversed by formoterol via inhibition of PI3K signalling in peripheral blood mononuclear cells from patients with COPD and severe asthma Source: Annual Congress 2011 - Models of disease and drug actions Year: 2011
Effects of salbutamol on gas exchange abnormalities and sputum neutrophilia induced by adenosine 5‘-monophosphate (AMP) in mild asthma Source: Eur Respir J 2006; 28: Suppl. 50, 669s Year: 2006
Formoterol, but not salmeterol, restores corticosteroid sensitivity in peripheral blood mononuclear cells from COPD via PI3K inhibition Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD Year: 2008
Do leukotriene antagonists reduce eosinophil numbers in induced sputum from asthmatic patients as a consequence of increased apoptosis induction? Source: Eur Respir J 2002; 20: Suppl. 38, 584s Year: 2002
Interactive inhibitory effects of formoterol and montelukast on activated human neutrophils Source: Eur Respir J 2010; 36: 1417-1424 Year: 2010
Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation Source: Eur Respir J 2002; 19: 518-524 Year: 2002
The inhibitory effect of salbutamol on neutrophil's respiratory burst is enhanced by the SH-metabolite of erdosteine (mucoactive drug) Source: Eur Respir J 2002; 20: Suppl. 38, 617s Year: 2002
The selective phosphodiesterase 4 inhibitor, cilomilast, inhibits interleukin-8-induced pulmonary neutrophil accumulation in the rabbit Source: Eur Respir J 2001; 18: Suppl. 33, 35s Year: 2001
Low doses of inhaled fluticasone propionate induce sputum eosinophil apoptosis and inhibit IL-5 release in naive symptomatic asthmatics (FLIC19) Source: Eur Respir J 2001; 18: Suppl. 33, 336s Year: 2001
Protective effect of salbutamol on peripheral airway constriction induced by sputum induction in asthma patients Source: International Congress 2017 – Biomarker-based asthma control Year: 2017
Dose-dependent inhibitory effect of Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, on allergen-induced early and late asthmatic reaction Source: Eur Respir J 2002; 20: Suppl. 38, 110s Year: 2002
Effect of a novel inhaled glucocorticoid, ciclesonide, on an allergen-induced asthmatic response in rats and its prolonged anti-inflammatory activity in vitro Source: Eur Respir J 2002; 20: Suppl. 38, 91s Year: 2002
Anti-inflammatory effects of high-dose inhaled fluticasone versus oral prednisone in asthma exacerbations Source: Eur Respir J 2007; 30: 1143-1149 Year: 2007
Rolipram, a PDE4 inhibitor, but not prednisolone, inhibited pulmonary neutrophilia induced by intratracheal instillation of IL-8 in mice Source: Eur Respir J 2005; 26: Suppl. 49, 104s Year: 2005
The effect of montelukast on eosinophil apoptosis: Induced sputum findings of patients with mild persistant asthma Source: Eur Respir J 2003; 22: Suppl. 45, 101s Year: 2003