The interaction of ambroxol and NK-1 antagonist (L- 703,606) on reflex changes of ions transport in airways

N. Mlodzik, A. Lelinska, P. Kaczorowski, T. Tyrakowski (Bydgoszcz, Poland)

Source: Annual Congress 2003 - Fundamental research in developing new drugs
Session: Fundamental research in developing new drugs
Session type: Thematic Poster Session
Number: 735
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Mlodzik, A. Lelinska, P. Kaczorowski, T. Tyrakowski (Bydgoszcz, Poland). The interaction of ambroxol and NK-1 antagonist (L- 703,606) on reflex changes of ions transport in airways. Eur Respir J 2003; 22: Suppl. 45, 735

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Effect of AVE5883, a dual NK1/NK2 receptor antagonist, on airway responsiveness to neurokinin A in asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 219s
Year: 2004

Ethanol (EtOH) promotes Ca2+ mobilization and neuropeptide release from airway sensory nerves via vanilloid receptor 1 (VR1) activation
Source: Eur Respir J 2002; 20: Suppl. 38, 170s
Year: 2002

The role of CPA (adenosine A1 agonist) in airway reflexes
Source: Annual Congress 2004 - Neural regulation of airways and cough
Year: 2004


A new ultra-potent vanilloid receptor 1 (VR1) antagonist abates capsaicin and citric acid induced cough
Source: Eur Respir J 2002; 20: Suppl. 38, 190s
Year: 2002

The effect of leukotrienes and their receptor antagonists on calcium signalling in the cough receptors transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1)
Source: Annual Congress 2010 - Models of airways disease
Year: 2010


Different alcohols activate airway sensory nerves by a vanilloid receptor 1 (TRPV1) dependent mechanism
Source: Eur Respir J 2003; 22: Suppl. 45, 415s
Year: 2003

Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea
Source: Eur Respir J 2003; 21: 3-10
Year: 2003



Ethanol (EtOH) causes bronchoconstriction and plasma protein extravasation (PPE) in rodent airways via vanilloid receptor 1 (VR1) activation
Source: Eur Respir J 2002; 20: Suppl. 38, 485s
Year: 2002

The cannabinoid receptor agonist, WIN 55,212-2, inhibits antigen-induced plasma extravasation in guinea pig airways
Source: Annual Congress 2010 - Models of airways disease
Year: 2010


Effects of tachykinin receptor antagonists on lung function and plasma extravasation induced by HCl intraoesophageal instillation in rabbits
Source: Eur Respir J 2001; 18: Suppl. 33, 257s
Year: 2001

Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients
Source: Eur Respir J 2004; 23: 76-81
Year: 2004



The triple neurokinin receptor antagonist CS-003 inhibits neurokinin A (NKA)-induced bronchoconstriction in patients with asthma
Source: Eur Respir J 2003; 22: Suppl. 45, 415s
Year: 2003

EPAC drives the anti-tussive effect of EP4 receptors on airway sensory nerves
Source: Virtual Congress 2020 – Chronic cough: only symptom or disease?
Year: 2020




Aclidinium bromide, a novel muscarinic receptor antagonist combining long residence at M3 receptors and rapid plasma clearance
Source: Annual Congress 2007 - New drugs for COPD
Year: 2007


Discovery of competitive thromboxane receptor (TP) antagonism by diclofenac in guinea pig airway and vascular tissues
Source: Annual Congress 2007 - Recent advances in airway smooth muscle biology
Year: 2007


In vivo potent and long-lasting bronchodilator activity of muscarinic M3 receptor antagonist CHF5407
Source: Eur Respir J 2007; 30: Suppl. 51, 26s
Year: 2007

Novel triple neurokinin receptors antagonist CS-003 strongly inhibits neurokinin related responses
Source: Eur Respir J 2006; 28: Suppl. 50, 115s
Year: 2006

The antitussive effects of alpha7 (a7) nicotinic receptor agonists
Source: International Congress 2017 – Novel studies on bronchodilators and cough
Year: 2017



Vasopressin is involved in endothelin receptor antagonist-induced fluid retention in rat. Differential effect of selective ETA and dual ETA/ETB receptor antagonists
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Inhibition of cough reflex by D2 receptor agonism with Viozan™ (AR-C68397AA)
Source: Eur Respir J 2001; 18: Suppl. 33, 32s
Year: 2001