Pharmacological properties of a novel PI3Kd inhibitor, DS-1515

K. Wakita (Tokyo, Japan), K. Koyama (Tokyo, Japan), S. Nakayama (Tokyo, Japan), Y. Nishiya (Tokyo, Japan), P. Chopra (Gurgaon, India), M. Seth (Gurgaon, India), P. Chabbra (Gurgaon, India), P. Srivastava (Gurgaon, India), A. Kumar (Gurgaon, India), M. Diwan (Gurgaon, India), K. Morimoto (Tokyo, Japan), M. Suzuki (Tokyo, Japan)

Source: International Congress 2018 – Basic pharmacology
Session: Basic pharmacology
Session type: Thematic Poster
Number: 1054
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Wakita (Tokyo, Japan), K. Koyama (Tokyo, Japan), S. Nakayama (Tokyo, Japan), Y. Nishiya (Tokyo, Japan), P. Chopra (Gurgaon, India), M. Seth (Gurgaon, India), P. Chabbra (Gurgaon, India), P. Srivastava (Gurgaon, India), A. Kumar (Gurgaon, India), M. Diwan (Gurgaon, India), K. Morimoto (Tokyo, Japan), M. Suzuki (Tokyo, Japan). Pharmacological properties of a novel PI3Kd inhibitor, DS-1515. 1054

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
In vitro pharmacological characterization of the potent, lung selective pan-JAK inhibitor TD-8236
Source: International Congress 2019 – Advances in asthma pharmacology
Year: 2019


Pharmacological properties of novel LTC4 synthase inhibitor
Source: International Congress 2017 – Novel mechanisms and treatments for asthma
Year: 2017



In vitro pharmacological characterization of CHF6001, a novel selective phosphodiesterase 4 (PDE4) inhibitor with a robust anti-inflammatory profile
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


ADME properties of a novel PI3Kd inhibitor, DS-1515, in preclinical studies
Source: International Congress 2018 – Basic pharmacology
Year: 2018


In-vitro evaluation of a new potent, selective pan-Janus kinase (JAK) inhibitor VR588
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

The bronchodilatory and anti-inflammatory effect of MT-810, a novel selective phosphodiesterase-4 (PDE4) inhibitor
Source: Eur Respir J 2006; 28: Suppl. 50, 434s
Year: 2006

In vitro pharmacological profile of SMP-028, a novel potent anti-inflammatory agent
Source: Annual Congress 2010 - Models of airways disease
Year: 2010

In vitro and in vivo pharmacological profile of RP6503, a novel dual PI3K Δ/gamma inhibitor, in pulmonary disease systems
Source: Annual Congress 2013 –Emerging new targets for the treatment of respiratory diseases
Year: 2013

Pre-clinical characterization of RP3128, a novel and potent CRAC channel inhibitor for the treatment of respiratory disorders
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013


NIK-626; a dual inhibitor of thromboxane synthase and 5-lipoxygenase, potential candidate as a novel anti-asthma compound
Source: Eur Respir J 2001; 18: Suppl. 33, 264s
Year: 2001

Late-breaking abstract: Pre-clinical characterization of RP3128, a novel and potent CRAC channel inhibitor for the treatment of respiratory disorders
Source: Annual Congress 2011 - Late-Breaking Abstracts Session: New treatments and targets for airway disease
Year: 2011


In vitro and in vivo anti-inflammatory activity of the novel PDE4 inhibitor roflumilast
Source: Eur Respir J 2001; 18: Suppl. 33, 35s
Year: 2001

Pharmacological characterization of CHI25243, a novel potent inhaled inhibitor of neutrophil elastase
Source: International Congress 2016 – Therapeutic horizons: novel targets and pharmacological models
Year: 2016



Preclinical characterization of CPL-302-201, a novel, highly potent and selective PI3Kδ inhibitor for the treatment of inflammatory disorders
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Pharmacological profile and efficacy of GLPG1690, a novel ATX inhibitor for COPD treatment
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015


In vitro pharmacological characterization of a novel p38α (MAPK14) inhibitor designed for inhaled delivery
Source: International Congress 2016 – Novel insights into the treatment of COPD
Year: 2016


Pharmacological profile of a novel, potent and oral TRPA1 antagonist. Characterization in a preclinical model of induced cough
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

RP6503, a novel and selective PI3K δ/gamma inhibitor, potentiates the effect of steroids in pre-clinical models of COPD
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Pharmacological approach
Source: Annual Congress 2006 - The critically ill patient: chronic obstructive lung disease
Year: 2006


The pharmacological and safety profile of a novel selective phosphodiesterase-4(PDE4) inhibitor:- GRC- 3886
Source: Eur Respir J 2004; 24: Suppl. 48, 220s
Year: 2004