The mediators of allergen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung (IPL) are closely similar to those in asthmatics

E. Sundström, L. Låstbom, A. Ryrfeldt, S. E. Dahlén (Stockholm, Sweden)

Source: Annual Congress 2003 - Fundamental research in developing new drugs
Session: Fundamental research in developing new drugs
Session type: Thematic Poster Session
Number: 727
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
E. Sundström, L. Låstbom, A. Ryrfeldt, S. E. Dahlén (Stockholm, Sweden). The mediators of allergen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung (IPL) are closely similar to those in asthmatics. Eur Respir J 2003; 22: Suppl. 45, 727

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Salbutamol-induced bronchial hyperresponsiveness in passively sensitised guinea pigs; role of sensory nerves
Source: Eur Respir J 2001; 18: Suppl. 33, 265s
Year: 2001

"Asymptomatic" airway hyperresponsiveness in atopic guinea pigs
Source: Annual Congress 2009 - Animal models of airways inflammation
Year: 2009

Reduces inflammatory parameters in airways of diabetic-antigen sensitized guinea pigs
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011


The effects of PGD2 and DK-PGD2 on features of airway remodeling in human airway epithelial cells and guinea pig lung slices
Source: Virtual Congress 2020 – Clinical and laboratory pharmacology in asthma
Year: 2020


The histopathological characteristics and its effect on airway responsiveness in asthmatic guinea pigs
Source: Eur Respir J 2002; 20: Suppl. 38, 190s
Year: 2002

Late asthmatic response is modulated by TRPA1 antagonists in ovalbumin-induced bronchoconstriction in anaesthetized guinea pigs
Source: Annual Congress 2012 - New drug targets and pre-clinical models for respiratory diseases
Year: 2012


Budesonide-induced decrease of IL-5 production does not affect allergen-induced bronchoconstriction or AHR in a novel guinea pig asthma model
Source: International Congress 2019 – Novel insights from in vitro and in vivo models of lung disease
Year: 2019

Phenotypes of airways disease in repetitively antigen-challenged guinea pigs
Source: Annual Congress 2009 - Animal models of airways inflammation
Year: 2009

Attenuation of acethylcholine and antigen-induced lung parenchyma responsiveness by oral tolerance: a study in a model of chronic airway inflammation in guinea pigs
Source: Eur Respir J 2004; 24: Suppl. 48, 350s
Year: 2004

Effect of aerobic training on airway inflammation in chronic allergic sensitized guinea pigs
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


Polymerized type I collagen reverts airway hyperresponsiveness development in a guinea pig asthma model
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011


Remodelling and inflammation in a guinea pig model of COPD: effects of tiotropium
Source: Annual Congress 2009 - Translational research/biomarkers
Year: 2009


AWD 12-281, a new PDE4-inhibitor, suppresses allergen-induced [DCquote]early phase“ bronchoconstriction in sensitized guinea pigs
Source: Eur Respir J 2003; 22: Suppl. 45, 107s
Year: 2003

Effects of corticosteroid and montelukast treatment on distal lung parenchyma and airway walls in inflammation in guinea pigs with chronic allergic inflammation
Source: Annual Congress 2011 - Experimental modulation of airway inflammation
Year: 2011

Mechanism of NK1-mediated bronchoconstriction in passively sensitized human lung tissue.
Source: International Congress 2018 – Translational models of the immunopathology that underlies airway obstructive diseases
Year: 2018

Hyporeactive airways from hyperresponsive pigs
Source: Eur Respir J 2001; 18: Suppl. 33, 31s
Year: 2001

Relaxin potentiates ß2-adrenoceptor mediated bronchodilation in precision-cut lung slices (PCLS) from mouse models of airway inflammation and fibrosis, and in human airways
Source: International Congress 2019 – Advances in asthma pharmacology
Year: 2019

Effects of neurokinins on nNOS expression in bronchial epithelial and inflammatory cells in airways of guinea pigs
Source: Eur Respir J 2005; 26: Suppl. 49, 340s
Year: 2005

Expression of mast cell tryptase in bronchial mucosa of asthmatic guinea pigs
Source: Eur Respir J 2002; 20: Suppl. 38, 512s
Year: 2002

Physiological responses of the airway wall and lung in hyperresponsive pigs
Source: Eur Respir J 2001; 18: 935-941
Year: 2001