A critical role for mTOR regulated metabolic reprogramming during TGF-? induced fibroblast collagen synthesis Source: ERS Lung Science Conference 2017 Year: 2017
LSC - 2017 - mTOR-mediated cap-dependent translation is essential for human lung myofibroblast differentiation and collagen I synthesis Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis Year: 2017
LSC - 2018 - FKBP10 regulates fibroblast migration via synthesis of collagen VI Source: International Congress 2018 – New insights in the signalling pathways that underlie IPF pathophysiology Year: 2018
LSC - 2018 - MTOR regulates TGFß-induced collagen synthesis via increased glycine biosynthesis Source: International Congress 2018 – Pulmonary fibrosis: from models to patients Year: 2018
In vitro profibrotic effects of rapamycin on basal or TGF-β1 induced primary human lung fibroblast: ECM production and turnover, migration and differentiation Source: Annual Congress 2012 - Diffuse parenchymal lung disease I Year: 2012
TGFβ induced myofibroblast differentiation is independent of p38 activation, but requires TGFβR1 kinase activity and correlates with TGFβ-mediated SMAD signaling and TGFβ-responsive gene expression patterns in human lung fibroblasts Source: Eur Respir J 2004; 24: Suppl. 48, 718s Year: 2004
Differential role of EPAC and PKA in the transduction of cAMP-mediated inhibition of human lung fibroblast proliferation and collagen synthesis Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation Year: 2009
LSC - 2017 - RNA-Seq analysis reveals major differences between the effects of rapamycin and dual mTORC1/2 inhibition during TGFß1-induced myofibroblast differentiation Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis Year: 2017
ERK1/2 mediated expression and release of VEGF in human airway smooth muscle cells in relation to fibroblast growth factors: role of azithromycin Source: Annual Congress 2009 - Airway cell biology Year: 2009
p38 MAPK/MSK1/CREB signal pathway involves in transforming growth factor-β-induced heme oxygenase-1 expression in human lung epithelial cells Source: Eur Respir J 2007; 30: Suppl. 51, 544s Year: 2007
Hepatocyte and keratinocyte growth factor (HGF and KGF prevent rat alveolar type II cells from mechanical stretch induced apoptosis – role of phosphoinositide 3-OH kinase Source: Eur Respir J 2007; 30: Suppl. 51, 292s Year: 2007
LSC - 2018 - PRRX1 a pro-fibrotic mesenchymal transcription factor modulated by remodeled microenvironment in IPF Source: International Congress 2018 – New insights in the signalling pathways that underlie IPF pathophysiology Year: 2018
Transforming growth factor-β inhibition of lung fibroblast proliferation is mediated through prostaglandin E2 , via activation of p38 mitogen-activated protein kinase Source: Annual Congress 2005 - Pulmonary hypertension and fibrosis: novel mechanisms Year: 2005
Glucocorticoids promote TGF-β signalling in lung fibroblasts by upregulating ligand and receptor expression, and uncoupling negative-feedback inhibition Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases Year: 2010
Jun kinase regulates the expression of TGF-beta induced connective tissue growth factor in human lung fibroblast Source: Annual Congress 2004 - Inflammation and remodelling in human lungs Year: 2004
BMP-Smad1 target gene Wnt inhibitory factor 1 (WIF1) coordinates BMP and Wnt signaling activities in regulating lung development in vivo Source: Annual Congress 2010 - New mechanisms in lung development, acute and chronic lung diseases Year: 2010
RB2/p130 gene-enhanced expression downregulates vascular endothelial growth factor expression and inhibits angiogenesis in vivo Source: Eur Respir J 2002; 20: Suppl. 38, 3s Year: 2002
HIF dependent regulation of S100A4 protein in COPD induced vascular remodelling Source: Annual Congress 2010 - Pulmonary circulation I Year: 2010
miR-146a-5p plays an essential role in the aberrant epithelial–fibroblast cross-talk in COPD Source: Eur Respir J, 49 (5) 1602538; 10.1183/13993003.02538-2016 Year: 2017