LSC - 2017 - A critical role for mTOR regulated metabolic reprogramming during TGF-ß induced fibroblast collagen synthesis Source: International Congress 2017 – Novel mechanisms and therapeutic targets in lung injury and repair Year: 2017
TGFβ induced myofibroblast differentiation is independent of p38 activation, but requires TGFβR1 kinase activity and correlates with TGFβ-mediated SMAD signaling and TGFβ-responsive gene expression patterns in human lung fibroblasts Source: Eur Respir J 2004; 24: Suppl. 48, 718s Year: 2004
Selective inhibition of COX-2 by celecoxib exerts negative effects on endothelial progenitor cell proliferation and stimulates apoptosis in vitro Source: Eur Respir J 2005; 26: Suppl. 49, 368s Year: 2005
Late Breaking Abstract - Combinative analysis of RNA-seq and proteomics reveals potential molecular targets in TGF-beta1-induced fibroblast-myofibroblast transition Source: Virtual Congress 2020 – New clinical insights into idiopathic pulmonary fibrosis Year: 2020
P38 signalling pathway in primary cultures of human bronchial epithelial cells: effects of transforming growth factor-β and pharmacological modulation by budesonide Source: Eur Respir J 2002; 20: Suppl. 38, 571s Year: 2002
LSC - 2021 - Effect of mTOR inhibition in a 3D in vitro model of alveolar epithelium and epithelial regeneration Source: Virtual Congress 2021 – In vitro modelling of lung disease: reach out to the next dimension Year: 2021
BAL cell transcriptome predicts survival in IPF and can be used to gauge and model treatment effects interfering with the TGF-beta pathway Source: International Congress 2018 – Progress in basic and translational research on idiopathic interstitial pneumonias Year: 2018
Validation of the pitavastatin-induced angiomotin-like protein 1 that controls tight junction stability of lung microvascular endothelial cells via LKB1/AMPK activation Source: International Congress 2015 – New insights into lung disease pathogenesis Year: 2015
LSC - 2017 - mTOR-mediated cap-dependent translation is essential for human lung myofibroblast differentiation and collagen I synthesis Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis Year: 2017
Effect of rHuKGF in vegf dependent cell survival progression in emphysematous condition via akt signalling pathway Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases Year: 2013
LSC 2013 abstract - NF-κbeta acts downstream of EGFR in regulating low dose cadmium induced primary lung cell proliferation Source: Annual Congress 2013 –Cell signalling and inflammation: what's new in 2013? Year: 2013
The effect of bortezomib (Velcade®) on endothelial progenitor cell functions in vitro Source: Annual Congress 2007 - Pathogenesis and novel therapeutic targets in pulmonary hypertension Year: 2007
GSK-3 inhibition suppresses lung cancer cell survival, metastasis and proliferation through down-regulation the phosphorylation sites of CAP1 Source: International Congress 2017 – Lung cancer - basic science: the latest results from the bench Year: 2017
In vitro profibrotic effects of rapamycin on basal or TGF-β1 induced primary human lung fibroblast: ECM production and turnover, migration and differentiation Source: Annual Congress 2012 - Diffuse parenchymal lung disease I Year: 2012
Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK / mitochondrial pathway Source: Annual Congress 2008 - Novel trends in functional genomics and molecular pathology of neoplastic and non-neoplastic lung diseases Year: 2008
Differential response to stretch in different lung cells is related to differences in pi3k signalling Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury Year: 2009
Targeting the mTOR signaling pathway to inhibit lung cell senescence in COPD Source: International Congress 2016 – New signalling pathways in COPD Year: 2016
rHuKGF optimistically attenuates MAPK/ERK mediated cell proliferation pathway in emphysematous lungs Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases Year: 2013
Dual aVß6/aVß1 inhibitor PLN-74809 blocks multiple TGF-ß activation pathways associated with IPF Source: International Congress 2019 – Translational aspects of idiopathic interstitial pneumonia Year: 2019
Effects of TGF-beta and budesonide on MAPK phosphorylation, IL-6/IL-11 secretion, and cell proliferation in human lung fibroblasts Source: Eur Respir J 2006; 28: Suppl. 50, 662s Year: 2006