A neo-epitope of serum lysyl oxidase like 2 (LOXL2) generated during enzyme maturation is elevated in cancer and idiopathic pulmonary disease

D. Leeming (Herlev, Denmark)

Source: International Congress 2017 – Techniques in biomarker selection
Session: Techniques in biomarker selection
Session type: Oral Presentation
Number: 2934
Disease area: Interstitial lung diseases

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Leeming (Herlev, Denmark). A neo-epitope of serum lysyl oxidase like 2 (LOXL2) generated during enzyme maturation is elevated in cancer and idiopathic pulmonary disease. 2934

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Serum lysyl oxidase-like 2 levels and idiopathic pulmonary fibrosis disease progression
Source: Eur Respir J 2014; 43: 1430-1438
Year: 2014



Erythropoietin (EPO) inhibits the immunohistochemical expression of lysyl oxidase (LOX) in bleomycin (BLM)-induced pulmonary fibrosis (PF) in rats
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015

Elevated serum LOXL2 levels are associated with rapid disease progression in idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2012 - Idiopathic pulmonary fibrosis
Year: 2012

LSC 2013 abstract - NADPH oxidase isoform 2 (NOX2) is expressed in alveolar macrophages of emphysematous patients and prevents elastase-induced emphysema through the involvement of MMP9/TIMP1 gene expression
Source: Annual Congress 2013 –Translational studies in chronic repair and remodelling in the lung
Year: 2013

Dependence of stage of severity of chronic obstructive pulmonary disease on metalloproteinase 1, 12, surfactant protein C, microsomal epoxid hydrolase gene polymorphisms
Source: Eur Respir J 2006; 28: Suppl. 50, 523s
Year: 2006

NADPH oxidase isoform 1 is expressed in lung tissue of ARDS patients and decreases hyperoxia-induced ROS production and cell death in pulmonary type II epithelial cells
Source: Annual Congress 2011 - Barrier functions in sepsis and acute lung injury
Year: 2011


Activation of membrane nadph oxidase in idiopathic pulmonary fibrosis (IPF) fibroblasts
Source: Annual Congress 2007 - Recent advances in the understanding of lung injury and repair
Year: 2007


A neo-epitope of collagen type VII (C7) is elevated in serum of patients with COPD and SSC
Source: International Congress 2016 – Exploring mechanisms in health and disease
Year: 2016

Biochemical and functional characterization of lysyl oxidase like 2 (LOXL2) inhibitors
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014


Effect of recombinant α-1 antitrypsin (rAAT) and TAPI on neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP9) activity in induced sputum (IS) from healthy smokers and patients with chronic obstructive pulmonary disease (COPD)
Source: Annual Congress 2003 - Progress on therapy for chronic obstructive pulmonary disease
Year: 2003


FK506-binding protein 11, a novel plasma cell specific antibody folding catalyst, is increased in idiopathic pulmonary fibrosis
Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Year: 2020


Serum levels of a MMP-12 generated type IV collagen fragment is elevated in COPD and IPF patients
Source: Annual Congress 2013 –Systemic and airway biomarkers in respiratory diseases
Year: 2013


Definition of trypsin-like enzymes activity as the marker of severity of idiopathic pulmonary fibrosis
Source: International Congress 2018 – Back to basics and translational research in idiopathic interstitial pneumonias
Year: 2018

NADPH oxidase 4 deficiency protects from bleomycin-induced epithelial cell death and pulmonary fibrosis
Source: Annual Congress 2010 - New insights into reactive oxygen species
Year: 2010


MiR-320c regulates SERPINA1 expression and is associated with pulmonary disease in alpha-1-antitrypsin deficiency
Source: International Congress 2016 – How the understanding og molecular and genomic crosstalk is helping to diagnose lung disease
Year: 2016

Relationship between circulating serpina 3g, activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1, 2 with chronic obstructive pulmonary disease severity
Source: International Congress 2018 – Studying novel biomarkers in asthma and COPD
Year: 2018

Plasma level of total hydroperoxide (TH) as a marker of oxidative stress seems to be a useful index of disease severity in patients with idiopathic pulmonary fibrosis (IPF)
Source: Eur Respir J 2005; 26: Suppl. 49, 335s
Year: 2005

Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients
Source: Eur Respir J 2005; 25: 885-890
Year: 2005



Lysyl oxidases in idiopathic pulmonary fibrosis: A key participant in collagen I matrix remodelling
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015

Regulation, cell-specific expression and metabolism of factor VII activating protease (FSAP) in lungs from patients with acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis (IPF)
Source: Eur Respir J 2006; 28: Suppl. 50, 823s
Year: 2006