Cytoplasmic signaling of polyinosinic-polycytidylic acid stimulates a quick and potent interferon response in primary macrophages

N. Dauletbaev (Montréal, QC, Canada)

Source: International Congress 2017 – New insights into pathogenesis of lung disease 
Session: New insights into pathogenesis of lung disease 
Session type: Poster Discussion
Number: 2030
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Dauletbaev (Montréal, QC, Canada). Cytoplasmic signaling of polyinosinic-polycytidylic acid stimulates a quick and potent interferon response in primary macrophages. 2030

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Cytotoxicity of liposome-encapsulated polyinosinic-polycytidylic acid in primary human macrophages is only partially related to interferon-ß
Source: International Congress 2018 – Basic pharmacology
Year: 2018


Intermittent hypoxia activates the Interleukin (IL)-1ß and nuclear factor (NF)?B signaling pathway in primary murine macrophages
Source: International Congress 2019 – Insights into the pathophysiology of sleep-disordered breathing
Year: 2019



Stimulation with polyinosinic-polycytidylic acid (poly(I:C)) encapsulated within novel pH-sensitive switchable liposomes leads to a faster and more potent interferon response
Source: International Congress 2016 – Pulmonary drug delivery
Year: 2016


Simvastatin suppresses RANTES-mediated neutrophilia in polyinosinic–polycytidylic acid-induced pneumonia
Source: Eur Respir J 2013; 41: 1147-1156
Year: 2013



Double-stranded RNA upregulates TLR3 and induces pro-inflammatory, and innate immune cytokine expression in human bronchial smooth muscle cells
Source: Annual Congress 2010 - Airway smooth muscle cells
Year: 2010

Effects of extracellular Hsp70, lipoteichoic acid and lipopolysaccharide on TLR2 and TLR4 mRNA expression in monocyte-derived macrophages
Source: International Congress 2019 – Immunopathological mechanisms of lung disease
Year: 2019


The antimicrobial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands
Source: Eur Respir J 2006; 28: Suppl. 50, 582s
Year: 2006

Mechanism of long-lasting suppression against Th2 immune response in the lung by a novel antedrug TLR7 agonist
Source: Annual Congress 2011 - T-cell subsets
Year: 2011

Anti–fibrotic efficacy of Lck inhibitor via the suppression of TGF–ß production in regulatory T cells
Source: Virtual Congress 2021 – Translational and other aspects of idiopathic interstitial pneumonia
Year: 2021


Bile acid receptor mediates TGF-ß1-induced activation of lung fibroblasts
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017

Late-breaking abstract: Activation of the macrophage inflammasome by TLR3 ligation potentiates release of IL-8 and IP-10 from alveolar type II epithelial cells via a paracrine cytokine network
Source: Annual Congress 2011 - Epithelial cells: role in health and disease
Year: 2011

Synergistic suppression of human rhinovirus induced pro-inflammatory cytokines by B2 agonists and glucocorticoids
Source: Annual Congress 2004 - Mechanisms and treatment of virus induced asthma exacerbations
Year: 2004


Adapalene abrogates erlotinib-induced skin disorder by regulating proinflammatory cytokine production from human epidermal cells
Source: International Congress 2018 – Lung cancer: personalised medicine
Year: 2018




Bile acid receptor accelerates to the lung cancer process induced by lung fibroblast-tumor cells interaction, with high activation of phosphorylated STAT3 and alteration of cytokine secretion
Source: International Congress 2017 – Lung cancer - basic science: the latest results from the bench
Year: 2017

Increased expression of microRNA-146a negatively regulates both the LPS and Poly (I:C) induced inflammatory response in monocytes
Source: Annual Congress 2010 - Macrophages: cell biology and disease-specific characteristics
Year: 2010

Oral Presentation: Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells
Source: Lung Science Conference 2011 - Immune system dysregulation in chronic lung disease
Year: 2011



DTX3L mediated regulation of TBK1 positively regulates type I IFN signalingpathway and cellular antiviral response
Source: Virtual Congress 2020 – Different aspects of paediatric viral and bacterial lung infections
Year: 2020

Curcumin induces glutathione biosynthesis and inhibits NF-κB activation and interleukin-8 release in alveolar epithelial cells
Source: Eur Respir J 2004; 24: Suppl. 48, 29s
Year: 2004

The perxisome proliferator-activated receptor gamma agonist, rosiglitazone, inhibits IL-8 synthesis by airway epithelial cells stimulated with monocyte-derived microparticles
Source: Annual Congress 2007 - Epithelial networks in the airways
Year: 2007


Defective endogenous antiviral mediator production in response to viral infection
Source: International Congress 2015 – Resolving inflammation
Year: 2015