QLF change is more sensitive than FVC change in predicting Progression Free survival (PFS) in IPF trials

J. Goldin (Santa Monica, United States of America)

Source: International Congress 2017 – Idiopathic pulmonary fibrosis (IPF): clinical problems
Session: Idiopathic pulmonary fibrosis (IPF): clinical problems
Session type: Oral Presentation
Number: 1958
Disease area: Interstitial lung diseases

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Goldin (Santa Monica, United States of America). QLF change is more sensitive than FVC change in predicting Progression Free survival (PFS) in IPF trials. 1958

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Short term Quantitative Lung Fibrosis (QLF) change predicts rapid rate of FVC decline in patients with IPF
Source: International Congress 2017 – ILDs: clinical aspects
Year: 2017


Percent predicted forced vital capacity (FVC) is a reliable, valid, and responsive measure of clinical status in patients with idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2010 - Clinical issues in idiopathic pulmonary fibrosis
Year: 2010

Clinical and biological predictors of progression-free survival (PFS) and overall survival (OS) in patients (pts) with advanced non-small-cell lung cancer (NSCLC) treated by erlotinib in the ERMETIC cohort
Source: Annual Congress 2010 - The role of biomarkers in lung cancer
Year: 2010


Automatic quantitative fibrosis scores at baseline is a predictor of progression in patients with IPF
Source: International Congress 2017 – Idiopathic pulmonary fibrosis (IPF): clinical problems
Year: 2017

Umeclidinium/vilanterol in preventing clinically important deterioration (CID) in COPD and impact of baseline disease severity: the EMAX trial
Source: International Congress 2019 – COPD clinical trials: inhaled and oral therapies
Year: 2019


The importance of the disease-free survival (DFS) endpoint to survivors of lung cancer
Source: Virtual Congress 2021 – Screening, diagnosis, management and prognosis of lung cancer
Year: 2021


FVC decline over 1 year predicts mortality but not subsequent FVC decline in patients with IPF
Source: International Congress 2017 – Idiopathic pulmonary fibrosis: from the bench to the bedside
Year: 2017


Do worse scores on patient-reported outcomes predict the progression of interstitial lung disease (ILD)?
Source: Virtual Congress 2021 – Interstitial lung disease around the world
Year: 2021


Multicomponent indices to predict survival in COPD: the COCOMICS study
Source: Eur Respir J 2013; 42: 323-332
Year: 2013



Improved survival with increased IC/TLC ratio, DLCO and FEV1 in an analysis of a COPD pulmonary function database
Source: Annual Congress 2011 - Lung and airway function
Year: 2011


Multicomponent indices to predict survival in COPD
Source: Eur Respir J 2014; 43: 1206
Year: 2014


Multicomponent indices to predict survival in COPD
Source: Eur Respir J 2014; 43: 1207
Year: 2014


Blood biomarkers predicting disease progression in patients with IPF: data from the INMARK trial
Source: International Congress 2019 – The evolving field of idiopathic interstitial pneumonia
Year: 2019




The incremental shuttle walk test (ISW) in patients with bronchiectasis: Response to pulmonary rehabilitation (PR) and minimum clinically important difference (MCID)
Source: International Congress 2019 – Hot topics in pulmonary rehabilitation
Year: 2019

Annual rate of FVC decline in patients with IPF treated with pirfenidone: Pooled analysis from 3 pivotal studies
Source: International Congress 2016 – IPF treatment I
Year: 2016


Long-term overall survival and progression-free survival in idiopathic pulmonary fibrosis treated by pirfenidone or nintedanib or their switch. Real world data from the EMPIRE registry.
Source: International Congress 2019 – Interstitial lung disease registries
Year: 2019


Novel patterns of serum biomarkers profiling using minimal important clinical outcomes (MICO) in the longidutinal study BODE cohort of COPD patients
Source: Annual Congress 2010 - COPD: symptoms and staging
Year: 2010


Impact of baseline desaturation during a six minute walk test (6MWT) on prognostic value of subsequent changes in FVC and DLCO
Source: Eur Respir J 2006; 28: Suppl. 50, 828s
Year: 2006

Early changes in eDiary COPD symptoms predict trough FEV1 and TDI responders at 12 weeks in the CRYSTAL trial
Source: International Congress 2017 – Management of COPD
Year: 2017


Predicting IPF outcomes: lung function evaluation by %predicted and z-score
Source: Virtual Congress 2021 – Biomarkers and e-health in idiopathic interstitial pneumonia
Year: 2021