Heat shock protein 90 inhibitors block pulmonary fibrosis and dysfunction in HCl-exposed mice.

J. Catravas (Norfolk, United States of America)

Source: International Congress 2017 – Novel pro- and anti-fibrotic mechanisms in pulmonary fibrosis
Session: Novel pro- and anti-fibrotic mechanisms in pulmonary fibrosis
Session type: Thematic Poster
Number: 1033
Disease area: Interstitial lung diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Catravas (Norfolk, United States of America). Heat shock protein 90 inhibitors block pulmonary fibrosis and dysfunction in HCl-exposed mice.. 1033

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Aminoguanidine attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of heat shock protein 47 and TGF-β1 expression
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008


The potential role of intracellular heat shock protein 70 deficiency in aging and pulmonary fibrosis.
Source: International Congress 2017 – Novel pro- and anti-fibrotic mechanisms in pulmonary fibrosis
Year: 2017


The heat shock protein 90 inhibitor, 17-AAG, ameliorates pulmonary arteriolar and right ventricular hypertrophy in monocrotaline-induced pulmonary arterial hypertension
Source: Annual Congress 2009 - Pulmonary circulation II
Year: 2009

Post-treatment with the heat shock protein 90 (hsp90) inhibitor, AUY-922, reduces lung hsp90 tyrosine (Y) phosphorylation and pulmonary inflammation in LPS-induced acute lung injury (ALI) in mice
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013

Heat shock protein: a hot topic in idiopathic pulmonary fibrosis
Source: Eur Respir J , 49 (2) 1602152; DOI: 10.1183/13993003.02152-2016
Year: 2017


Heat shock proteins 70 and 90 expression in peripheral lung of COPD patients
Source: Annual Congress 2008 - Novel mechanisms and targets of molecular pulmonary pathology
Year: 2008

Increased expression of heat shock protein 70 in COPD
Source: Annual Congress 2010 - Novel markers of lung injury
Year: 2010

Vascular remodeling in the lung from mice treated with monocrotaline. The effect of protein C inhibitor transgenic expression
Source: Eur Respir J 2006; 28: Suppl. 50, 823s
Year: 2006

Enhanced lung fibrosis in protein C inhibitor transgenic mice
Source: Eur Respir J 2004; 24: Suppl. 48, 481s
Year: 2004

Protective effect of heat shock protein 90 (hsp90) inhibitors on endothelial barrier function
Source: Annual Congress 2007 - Acute and chronic lung injury and its repair: novel molecular insight
Year: 2007



Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis
Source: Eur Respir J 2004; 24: 57-65
Year: 2004



Expression of heat shock protein 47 in chronic hypersensitivity pneumonitis
Source: International Congress 2015 – Interstitial lung diseases I
Year: 2015

Hypoxemic vs. normoxemic resuscitation from hemorrhagic shock attenuates pulmonary endothelial dysfunction
Source: Annual Congress 2007 - Pulmonary infections and inflammation
Year: 2007


Heat shock protein-90 toward theranostics: a breath of fresh air in idiopathic pulmonary fibrosis
Source: Eur Respir J, 51 (2) 1702612; 10.1183/13993003.02612-2017
Year: 2018



Nintedanib has acute pulmonary vasodilatory effects in transgenic Fra2 mice with spontaneous progressive pulmonary hypertension and lung fibrosis.
Source: International Congress 2019 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2019

The effect of dexamethasone on the pulmonary fibrosis of acute lung injury induced by lipopolysaccharide in rats
Source: Annual Congress 2007 - Respiratory pathophysiology
Year: 2007


Heat shock proteins (HSP)-10 and –40 increase in bronchial biopsies of patients with severe chronic obstructive pulmonary disease
Source: Annual Congress 2008 - Invasive and noninvasive measurements of lung inflammation
Year: 2008


Hypoxemic resuscitation of hemorrhagic shock attenuates the pulmonary oxidative and inflammatory responses
Source: Eur Respir J 2005; 26: Suppl. 49, 222s
Year: 2005

Serum heat shock protein 47 levels in patients with drug induced lung diseases
Source: Annual Congress 2013 –Connective tissue disease and interstitial lung disease
Year: 2013

Effect of NF-?B inhibitor IMD-1041 on BLM-induced pulmonary fibrosis in mice
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017