Effects of phosphodiesterase 3/4 inhibition on matrixmetalloproteinases 2 and 9 in chronic experimental pulmonary hypertension

R. T. Schermuly, S. Pullamsetti, A. Samidurai, N. Weissmann, H. A. Ghofrani, F. Rose, C. Schudt, W. Seeger, F. Grimminger (Giessen, Konstanz, Germany)

Source: Annual Congress 2004 - Pathophysiology of pulmonary hypertension
Session: Pathophysiology of pulmonary hypertension
Session type: Oral Presentation
Number: 2690
Disease area: Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
R. T. Schermuly, S. Pullamsetti, A. Samidurai, N. Weissmann, H. A. Ghofrani, F. Rose, C. Schudt, W. Seeger, F. Grimminger (Giessen, Konstanz, Germany). Effects of phosphodiesterase 3/4 inhibition on matrixmetalloproteinases 2 and 9 in chronic experimental pulmonary hypertension. Eur Respir J 2004; 24: Suppl. 48, 2690

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Partial reversal of experimental pulmonary hypertension by phosphodiesterase 3/4 inhibition
Source: Eur Respir J 2006; 28: Suppl. 50, 804s
Year: 2006

Effect of phosphodiesterase 4B inhibitor GSK256066 on leukocyte/endothelium interactions from chronic obstructive pulmonary disease: an in vitro study.
Source: International Congress 2017 – Management of COPD
Year: 2017


Effect of phosphodiesterase 5 inhibitor in patients with pulmonary hypertension associated with chronic obstructive pulmonary disease
Source: Virtual Congress 2021 – Therapy of pulmonary hypertension
Year: 2021


RESPITE: Riociguat in pulmonary arterial hypertension patients with an inadequate response to phosphodiesterase type 5 inhibitors
Source: International Congress 2016 – Clinic of pulmonary hypertension
Year: 2016


Effects of iloprost and the phosphodiesterase inhibitor tolafentrine on pulmonary vascular remodelling in chronic experimental pulmonary hypertension
Source: Eur Respir J 2003; 22: Suppl. 45, 20s
Year: 2003

Comparison of acute hemodynamic effects of three different phosphodiesterase inhibitors in patients with pulmonary arterial hypertension
Source: Eur Respir J 2004; 24: Suppl. 48, 705s
Year: 2004

Treatment effects of Rho-kinase (Rock) inhibition vs. phosphodiesterase-5 (PDE5) inhibition on cardiac function and metabolism in monocrotaline induced pulmonary arterial hypertension
Source: Eur Respir J 2006; 28: Suppl. 50, 547s
Year: 2006

Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice
Source: Eur Respir J 2006; 27: 1102-1109
Year: 2006



Phosphodiesterase 1 upregulation in pulmonary arterial hypertension – target for anti-remodeling therapy
Source: Eur Respir J 2006; 28: Suppl. 50, 159s
Year: 2006

Effect of PDE-5 inhibitor treatment in patients with interstitial lung disease and pulmonary hypertension
Source: Annual Congress 2011 - Clinical perspectives in several interstitial diseases
Year: 2011

Phosphodiesterase 4 and 5 inhibitor and steroid actions on pulmonary injury induced by microcystin-LR
Source: Annual Congress 2008 - Respiratory structure and function
Year: 2008

Phosphodiesterase-type 3 inhibitor potentiates cAMP generation and antiproliferative effects of treprostinil in pulmonary arterial smooth muscle cells from patients with pulmonary hypertension
Source: Annual Congress 2010 - Pathobiology of pulmonary hypertension
Year: 2010


Combined inhalation of iloprost and the dual selective phosphodiesterase (PDE) inhibitor tolafentrine in a model of acute pulmonary hypertension
Source: Eur Respir J 2001; 18: Suppl. 33, 198s
Year: 2001

Effects of a selective phosphodiesterase IV and V inhibitor in a murine model of chronic asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 128s
Year: 2004

Role of tadalafil in patients with hypoxia / lung disease induced (group 3) pulmonary hypertension
Source: International Congress 2016 – Pulmonary hypertension: the clinic I
Year: 2016

Severe pulmonary hypertension in chronic lung disease. Long term effects on gas exchange of endothelin receptor antagonists or PDE5 inhibitors
Source: Annual Congress 2011 - Pulmonary hypertension in hypoxic lung disease
Year: 2011

Current medical therapies in pulmonary arterial hypertension
Source: Eur Respir Mon 2012; 57: 26-41
Year: 2012


Phosphodiesterase inhibitors for the treatment of pulmonary hypertension
Source: Eur Respir J 2008; 32: 198-209
Year: 2008



Cilomilast, a potent, selective inhibitor of phosphodiesterase 4, improves small airway function in patients with chronic obstructive pulmonary disease: results of a 6-month trial
Source: Eur Respir J 2001; 18: Suppl. 33, 94s
Year: 2001

Pharmacological inhibition of carbonic anhydrases 9 and 12 attenuates monocrotaline-induced pulmonary hypertension in rats
Source: International Congress 2019 – Pulmonary hypertension with lung diseases and experimental pulmonary hypertension
Year: 2019