UR-13484, an orally active small molecule VLA-4 inhibitor that reduces lung inflammation

J. Alfón, E. González, A. Motos, R. Rosa, L. A. Gómez, M. Merlos, E. Carceller, J. Cortijo, E. Morcillo (Palau-solità i Plegamans, Valencia, Spain)

Source: Annual Congress 2004 - New and emerging pharmacological strategies in the treatment of asthma
Session: New and emerging pharmacological strategies in the treatment of asthma
Session type: Poster Discussion
Number: 1378
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Alfón, E. González, A. Motos, R. Rosa, L. A. Gómez, M. Merlos, E. Carceller, J. Cortijo, E. Morcillo (Palau-solità i Plegamans, Valencia, Spain). UR-13484, an orally active small molecule VLA-4 inhibitor that reduces lung inflammation. Eur Respir J 2004; 24: Suppl. 48, 1378

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
SD-208 an orally active TGF-β1 receptor antagonist inhibits TGF-β1 induced progressive lung fibrosis in rat
Source: Annual Congress 2003 - Animal models of lung injury: useful or not?
Year: 2003


Dose-dependent inhibitory effect of Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, on allergen-induced early and late asthmatic reaction
Source: Eur Respir J 2002; 20: Suppl. 38, 110s
Year: 2002

The selective phosphodiesterase 4 inhibitor, cilomilast, inhibits interleukin-8-induced pulmonary neutrophil accumulation in the rabbit
Source: Eur Respir J 2001; 18: Suppl. 33, 35s
Year: 2001

The potent and lung-selective inhaled pan JAK inhibitor TD-8236 limits airway inflammation without affecting systemic immunity in mice
Source: International Congress 2019 – Novel targets and mechanisms in asthma
Year: 2019




Roflumilast potently inhibits CXCL1 mediated neutrophil migration in COPD patients
Source: Annual Congress 2011 - COPD: clinical studies and animal cell models
Year: 2011

Roflumilast inhibits leukocyte cell interactions in vivo
Source: Eur Respir J 2006; 28: Suppl. 50, 224s
Year: 2006

Effects of CHF6297, a potent and selective p38a MAPK inhibitor, in murine models of steroid resistant lung inflammation
Source: International Congress 2017 – Towards new anti-inflammatory and anti-fibrotic agents
Year: 2017



Roflumilast, a new, orally active, selective PDE4 inhibitor, does not interact with inhaled budesonide
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

A functional variant of secretory leukocyte protease inhibitor (SLPI) with improved anti-inflammatory activity against pulmonary infection
Source: Lung Science Conference 2015
Year: 2015

Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1
Source: International Congress 2017 – Towards better treatments for lung disease: experimental pharmacology
Year: 2017

Roflumilast, a new, orally active, selective phosphodiesterase 4 inhibitor, is effective in the treatment of asthma
Source: Eur Respir J 2002; 20: Suppl. 38, 303s
Year: 2002

TD-0903, an inhaled JAK inhibitor in development for COVID-19, blocks ARDS-relevant hyperinflammation and lung injury in primary human immune and airway epithelial cells
Source: Virtual Congress 2021 – Emerging respiratory diseases: state-of-the-art studies of SARS-CoV-2 infection
Year: 2021



A decoy CXCL8 with increased glycosaminoglycan binding has potent anti-inflammatory activity in lung inflammation models
Source: Annual Congress 2010 - Pre-clinical models of airways disease
Year: 2010

PUR1800 (RV1162), A novel narrow spectrum kinase inhibitor, but not Fluticasone, reduces TNFa-induced cytokine release by primary bronchial epithelial cells from healthy volunteers and COPD patients
Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Year: 2018



The novel phosphodiesterase 4 inhibitor CI-1044 inhibits in vitro LPS-induced TNFα production in whole blood of COPD patients
Source: Eur Respir J 2001; 18: Suppl. 33, 34s
Year: 2001

Treatment with proteinase inhibitor, BbCI, modulates inflammatory response, mechanic alterations, and remodeling on elastase-induced emphysema in mice
Source: Annual Congress 2012 - The many roads to lung injury
Year: 2012

Inhibition of LPS-induced neutrophil recruitment in the lungs correlates with modulation of neutrophil CD11b expression using the selective CXCR2 receptor antagonist SB-656933
Source: Eur Respir J 2004; 24: Suppl. 48, 218s
Year: 2004

N-acetyl cysteine inhibits IL-17-induced IL-8 production from human airway smooth muscle cells - a possible role for anti-oxidant treatment in chronic lung rejection?
Source: Eur Respir J 2003; 22: Suppl. 45, 202s
Year: 2003

No interaction of roflumilast, a new, orally active, selective PDE4 inhibitor, with inhaled salbutamol
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Role of alveolar epithelial ICAM-1 in lipopolysaccharide-induced lung inflammation
Source: Eur Respir J 2002; 19: 1142-1150
Year: 2002