Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD

Satoru Yanagiasawa (London, United Kingdom), Satoru Yanagiasawa, Chaitanya Vuppusetty, Kazuhiro Ito, Peter J. Barnes

Source: International Congress 2016 – Studies in airway cell biology
Session: Studies in airway cell biology
Session type: Thematic Poster
Number: 3998
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Satoru Yanagiasawa (London, United Kingdom), Satoru Yanagiasawa, Chaitanya Vuppusetty, Kazuhiro Ito, Peter J. Barnes. Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD. Eur Respir J 2016; 48: Suppl. 60, 3998

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Alveolar macrophages activate STAT3 in epithelial cells via gp130 dependant steroid insensitive mechanism
Source: Annual Congress 2013 –Macrophages, mononuclear cells and viral infection
Year: 2013

Involvement of JNK in TNFα driven remodelling
Source: International Congress 2015 – Cellular and molecular mechanisms of COPD and emphysema
Year: 2015

Inhibition of IRAK4 suppresses chemokine release from human bronchial epithelial cells
Source: Annual Congress 2013 –Molecular biology: state-of-the-art 2013
Year: 2013

WNT-4 regulates pro-inflammatory responses driven by epithelial-mesenchymal cross-talk
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016

Egr-1 regulates muc5ac expression through activator protein-1 (AP-1) in chronic airway inflammation diseases
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015


PI3K and notch signal pathways coordinately regulate the activation and proliferation of T lymphocytes in asthma
Source: Annual Congress 2013 –Cell biology and murine models of asthma and inflammation
Year: 2013

IL-8 and TSLP production as markers of bronchial epithelial cell activation in IL-17A mediated airway inflammation in COPD: Role of tiotropium
Source: Annual Congress 2013 –New insights into epigenetic mechanisms in the lung
Year: 2013

Non-canonical WNT-5A signaling attenuates endogenous lung repair in COPD
Source: International Congress 2016 – New signalling pathways in COPD
Year: 2016

Altered scavenger receptor expression and response to oxidative stress is linked to defective bacterial phagocytosis in COPD macrophages
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

The AMPK-TSC1/2-mTOR signaling pathway regulates cigarette smoking-induced inflammation and apoptosis in airway epithelial cells
Source: International Congress 2015 – Molecular pathways of lung injury due to tobacco-related products
Year: 2015


Inhibition of VEGF blocks the activation of TGF-β1 through a PI3K/Akt signaling pathway in allergic airway disease of mice
Source: Annual Congress 2007 - Current issues in airway physiology, pharmacology and monitoring
Year: 2007


rHuKGF optimistically attenuates MAPK/ERK mediated cell proliferation pathway in emphysematous lungs
Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases
Year: 2013

Stimulation of NOD1 induces RIP2, TAK1 and p38 MAPK dependent pro-inflammatory signalling in human lung microvascular endothelial cells
Source: Annual Congress 2011 - Mechanisms of acute lung injury and mesenchymal cell treatment
Year: 2011


A role for WNT-5B in airway remodeling in COPD by activation of TGF-beta/Smad3 signaling?
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

Increased expression of sphingosine-1-phosphate and S1PR2 are associated with attenuated macrophage phagocytosis in COPD
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

Lung cancer-derived IL-8 increased osteoclastogenesis via phospholipase D signaling pathway
Source: Annual Congress 2010 - Pathology of lung cancer
Year: 2010


Long-term exposure to TNF-alpha and IL-1beta reduces vitamin D-mediated expression of the antimicrobial peptide hCAP18/LL-37 in primary bronchial epithelial cells (PBEC)
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013


Effects of budesonide on p38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Rhinovirus-induced proinflammatory cascade in bronchial epithelial cells requires xanthine-oxidase system activation
Source: Annual Congress 2008 - New diagnostic methods in viral and atypical infections
Year: 2008


Steroid resistance in COPD is associated with impaired molecular chaperone HSP90 expression by pro-inflammatory lymphocytes
Source: International Congress 2016 – Mechanisms of disease
Year: 2016