Comprehensive toll-like receptor stimulation and cytokine analysis in precision-cut lung slices

Marco Schlepütz (Biberach an der Riß, Germany), Marco Schlepütz, Elisabeth Waldmann, Cara Williams, Kirsten Arndt

Source: International Congress 2016 – Studies in airway cell biology
Session: Studies in airway cell biology
Session type: Thematic Poster
Number: 3991
Disease area: Airway diseases, Respiratory infections

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Marco Schlepütz (Biberach an der Riß, Germany), Marco Schlepütz, Elisabeth Waldmann, Cara Williams, Kirsten Arndt. Comprehensive toll-like receptor stimulation and cytokine analysis in precision-cut lung slices. Eur Respir J 2016; 48: Suppl. 60, 3991

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Eosinophilic airway inflammation is associated with increased TLR2 and TLR4 expression in adult asthmatics
Source: International Congress 2014 – TH17 and other acute asthmatic responses
Year: 2014


Mapping of eosinophil and basophils in COPD lung tissues
Source: International Congress 2015 – Mucosal immunology: what’s new in 2015
Year: 2015

TLR-3 triggered exacerbation of experimental asthma depends on IL-17 producing NK cells
Source: International Congress 2014 – TH17 and other acute asthmatic responses
Year: 2014

TSLP as biomarker in asthma patients
Source: International Congress 2015 – Systemic and airway biomarkers
Year: 2015


Sputum cell mRNA transcripts demonstrate alteration of endothelin metabolism in severe asthma and COPD
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013

IL-13-induced cytokine release and hyperresponsiveness in precision cut lung slices of different species – Characterization of a model potentially suitable for translational research of asthma cellular events
Source: Annual Congress 2013 –Origins and diagnosis of asthma
Year: 2013

Neuronal toll-like receptor (TLR) 7 expression and function in human airways
Source: International Congress 2014 – Novel approaches to human studies in allergy and asthma
Year: 2014


IL33 and TSLP involvements in influenza-induced exacerbation in a murine model of chronic asthma
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015

Anticholinergic treatment does not affect toll-like receptor 3-induced antiviral immune response in COPD bronchial epithelial cells
Source: International Congress 2015 – New data on established treatments for COPD
Year: 2015

Elevated IL-17A in very severe COPD is localized to mast cells and correlates with lung function decline
Source: International Congress 2014 – TH17 and other acute asthmatic responses
Year: 2014

Altered P2 receptor expression profile in sputum cells of patients with COPD
Source: International Congress 2014 – Monitoring COPD with different biomarkers
Year: 2014

The role of the frizzled-8 receptor in COPD with chronic mucus hypersecretion
Source: Annual Congress 2013 –Translational studies in chronic repair and remodelling in the lung
Year: 2013

Levels of cytokines, sCD31 and expression of CD38 in patients with bronchial asthma of various severity out of a disease exacerbation
Source: International Congress 2014 – Biomarkers of asthma and clinical immunology
Year: 2014

Cigarette smoke affects IL-17A, IL-17F and IL-17 receptor expression in the lung tissue of COPD patients: Ex vivo/in vitro studies
Source: International Congress 2014 – Mechanistic studies of the airway epithelium
Year: 2014

The role of chemokine receptors in the aberrant migration of COPD neutrophils
Source: International Congress 2014 – Cell biology 2014
Year: 2014

LATE-BREAKING ABSTRACT: TSLP as a potent activator of Th2 response in obstructive lung diseases
Source: International Congress 2016 – Novel mechanisms and therapeutic targets in acute and chronic inflammatory disease
Year: 2016


Expression of CysLT2 receptors in asthmatic lung, and the roles in bronchoconstriction
Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Year: 2014

Autoreactivity in patients with combined COPD and asthma phenotype
Source: International Congress 2014 – Novel approaches to human studies in allergy and asthma
Year: 2014


Therapeutic blockade of IL-4 and 13 signaling with dupilumab (SAR231893/REGN668) inhibits key biomarkers in asthma
Source: Annual Congress 2013 –Treatment of asthma
Year: 2013

ADAM9 is upregulated in human COPD lungs and in human and murine lung in response to cigarette smoke
Source: International Congress 2014 – New studies into pulmonary proteases and antiproteases
Year: 2014