Impaired coordination of skeletal muscle protein turnover signalling in sarcopenic COPD patients

Anita Kneppers (Maastricht, Netherlands), Anita Kneppers, Ramon Langen, Harry Gosker, Pieter Leermakers, Marco Kelders, Chiel de Theye, Nanca Cebron Lipovec, Daniel Omersa, Mitja Lainscak, Annemie Schols

Source: International Congress 2016 – How the understanding og molecular and genomic crosstalk is helping to diagnose lung disease
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Anita Kneppers (Maastricht, Netherlands), Anita Kneppers, Ramon Langen, Harry Gosker, Pieter Leermakers, Marco Kelders, Chiel de Theye, Nanca Cebron Lipovec, Daniel Omersa, Mitja Lainscak, Annemie Schols. Impaired coordination of skeletal muscle protein turnover signalling in sarcopenic COPD patients. Eur Respir J 2016; 48: Suppl. 60, 3400

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Impaired myogenesis in the quadriceps muscle of cachectic COPD patients
Source: International Congress 2014 – Respiratory pathophysiology: mechanisms of alteration of lung, respiratory and peripheral muscle function
Year: 2014


Peripheral muscle mitophagy is enhanced in patients with COPD
Source: International Congress 2016 – How the understanding og molecular and genomic crosstalk is helping to diagnose lung disease
Year: 2016

Increased autophagy and reduced protein synthesis signaling are involved in pulmonary inflammation-induced skeletal muscle atrophy
Source: International Congress 2016 – How the understanding og molecular and genomic crosstalk is helping to diagnose lung disease
Year: 2016

TNF-α-induced NF-κB activation stimulates skeletal muscle glycolytic metabolism through activation of HIF-1α
Source: International Congress 2015 – New insights into lung disease pathogenesis
Year: 2015

Reliability of using magnetic stimulation to evaluate muscle function in patients with severe to very severe COPD and healthy subjects
Source: International Congress 2016 – Effects of exercise training interventions in chronic respiratory disease
Year: 2016

Klotho expression is reduced in COPD
Source: Annual Congress 2013 –The latest insights in exercise testing and physical inactivity
Year: 2013

Mitochondrial functional alterations in COPD locomotor muscle are independent of cachexia and fiber type shift
Source: International Congress 2014 – Pathophysiological mechanisms at different scales
Year: 2014

The association of vitamine D deficiency and skeletal muscle dysfunction in COPD
Source: International Congress 2015 – Monitoring and phenotyping COPD
Year: 2015

Decreased expression of genes involved in skeletal muscle oxidative metabolism in COPD patients with muscle wasting
Source: Annual Congress 2008 - Respiratory muscle pathophysiology
Year: 2008

Intrinsic mitochondrial function in COPD is not impaired in lower limb skeletal muscle
Source: International Congress 2016 – From cardiopulmonary interaction to locomotor muscles and dyspnoea in health and disease
Year: 2016

Decreased muscle PPAR concentrations: a mechanism underlying skeletal muscle abnormalities in COPD?
Source: Eur Respir J 2007; 30: 191-193
Year: 2007


Altered muscle metabolism and muscle mass in patients with COPD
Source: International Congress 2017 – Neuromuscular consequences of respiratory diseases
Year: 2017



Role of exosomal microRNA in driving skeletal muscle wasting in COPD
Source: International Congress 2015 – Latest news on miRNAs in pulmonary research
Year: 2015


Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD
Source: Eur Respir J 2003; 22: 88-93
Year: 2003



Cultured satellite cells as a model for the study of muscle dysfunction in COPD
Source: Annual Congress 2013 –The best posters in exercise testing and physical inactivity
Year: 2013

Systemic inflammation is associated with mitophagy signalling in skeletal muscle of COPD patients
Source: International Congress 2018 – Functional genomics and COPD: new challenges
Year: 2018

Features of skeletal muscle dysfunction in COPD patients with obesity
Source: International Congress 2015 – COPD: chronic disease and comorbidities
Year: 2015


Gender differences in COPD patients: Skeletal muscle function and structure
Source: Annual Congress 2013 –Guidelines and exacerbations
Year: 2013

Effect of oxidative stress on mitochondrial function in airway smooth muscle (ASM) cells from COPD patients
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013