Stimulation with polyinosinic-polycytidylic acid (poly(I:C)) encapsulated within novel pH-sensitive switchable liposomes leads to a faster and more potent interferon response

Larry Lands (Montreal, Canada), Nurlan Dauletbaev, Maria Cammisano, Warren Viricel, Suli-Anne Laurin, Jeanne Leblond-Chain, Larry Lands

Source: International Congress 2016 – Pulmonary drug delivery
Session: Pulmonary drug delivery
Session type: Thematic Poster
Number: 965
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Larry Lands (Montreal, Canada), Nurlan Dauletbaev, Maria Cammisano, Warren Viricel, Suli-Anne Laurin, Jeanne Leblond-Chain, Larry Lands. Stimulation with polyinosinic-polycytidylic acid (poly(I:C)) encapsulated within novel pH-sensitive switchable liposomes leads to a faster and more potent interferon response. Eur Respir J 2016; 48: Suppl. 60, 965

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Cytoplasmic signaling of polyinosinic-polycytidylic acid stimulates a quick and potent interferon response in primary macrophages
Source: International Congress 2017 – New insights into pathogenesis of lung disease 
Year: 2017


Cytotoxicity of liposome-encapsulated polyinosinic-polycytidylic acid in primary human macrophages is only partially related to interferon-ß
Source: International Congress 2018 – Basic pharmacology
Year: 2018


Increased expression of microRNA-146a negatively regulates both the LPS and Poly (I:C) induced inflammatory response in monocytes
Source: Annual Congress 2010 - Macrophages: cell biology and disease-specific characteristics
Year: 2010

Synthetic response of stimulated respiratory epithelium: Modulation by prednisolone and iKK2 inhibition
Source: Annual Congress 2012 - New insights into airway epithelial cell physiology
Year: 2012


Drug loaded liposomes of mesalamine incorporated into disease responsive microgels (Micro) for treating allergic asthma: An approach using smart drug delivery system
Source: International Congress 2015 – Is asthma always an easy disease to diagnose and manage?
Year: 2015


The oppositedirection of LC3 A/B-I/II change in Raw264.7 cells and A549 cells treated with graphene oxide and its functionalized chemicals
Source: International Congress 2016 – Lung cancer and immune cells: friends or foes?
Year: 2016


Temporal characterization of murine genomic response to poly I:C stimulation reveals tri-phasic inflammatory response signatures
Source: Annual Congress 2011 - Anti-inflammatory strategies in acute lung injury
Year: 2011

Fast, efficient and realistic in vitro delivery of inhaled drugs to pulmonary cells: Application to the proteasome inhibitor bortezomib
Source: Annual Congress 2013 –Cutting edge: drug delivery to the airways
Year: 2013

Designed core-shell nanoparticles: intracellular localization and pro-inflammatory cytokine release in lung cells
Source: Annual Congress 2009 - Lung cell biology and immunology
Year: 2009

A molecule derived from mycobacterium tuberculosis Cpn60.1 (compound Y) inhibits lung inflammation induced by LPS in mice
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

Inhibition of the effect of epidermal growth factor (EGF) on lung cancer cells. The use of plasmids encoding specific siRNA molecules
Source: International Congress 2015 – Biomarkers, immunology and molecular pathology of lung cancer
Year: 2015

Double-stranded RNA analog, poly I:C modulates histamine-triggered Ca2+ signaling in human pulmonary arterial endothelial cells
Source: Annual Congress 2008 - Pulmonary vascular biology
Year: 2008


Late Breaking Abstract: Suppressed rhinovirus (RV) induced type III interferon production in alternatively activated macrophages
Source: Annual Congress 2010 - Macrophages: cell biology and disease-specific characteristics
Year: 2010

TNF alpha promotes coxsackie and adenovirus receptor (CAR) phosphorylation by PKC delta to drive leukocyte transepithelial migration
Source: International Congress 2014 – Cell biology 2014
Year: 2014


The antifibrotic effect of Imatinib loaded CD44 targeted gold nanoparticles (Im-CD44-GNP) relies on alveolar macrophage regulation
Source: International Congress 2018 – CTD-ILD and hypersensitivity pneumonitis: from the bench to the bedside
Year: 2018




Pirfenidone induced inhibition of p38 downregulates procoagulant microparticle generation by human alveolar epithelia cells
Source: International Congress 2016 – Translational studies in lung disease
Year: 2016


Stimulation of IL-8 release in respiratory cell cultures by increasing IL1-beta concentrations: Effect of budesonide
Source: Annual Congress 2013 –Asthma: new mechanisms and markers
Year: 2013


Effects of functionalised chalcones on pro-inflammatory mediator release from lung epithelial cells
Source: Annual Congress 2009 - Inflammatory cells and cytokines
Year: 2009


Recombinant human pulmonary surfactant protein-D (rhSP-D) modulates Th2 responses and suppresses IgE-facilitated allergen binding to B cells
Source: Annual Congress 2013 –Genetics and mechanisms of, and tests for, allergy
Year: 2013


The relationship between PBMC secretion of IFN-alpha following stimulation by Poly (I:C) and clinical indices in COPD
Source: Annual Congress 2010 - Colonisation and infection in COPD
Year: 2010