LSC Abstract – Eosinophils enhance WNT-5a and TGF-β1 genes expression in airway smooth muscle cells and promote their proliferation in asthma

Andrius Januskevicius (Kaunas, Lithuania), Andrius Januskevicius, Simona Lavinskiene, Reinoud Gosens, Ieva Janulaityte, Deimante Hoppenot, Raimundas Sakalauskas, Kestutis Malakauskas

Source: International Congress 2016 – Clinical characteristics of asthma
Session: Clinical characteristics of asthma
Session type: Thematic Poster
Number: 632
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Andrius Januskevicius (Kaunas, Lithuania), Andrius Januskevicius, Simona Lavinskiene, Reinoud Gosens, Ieva Janulaityte, Deimante Hoppenot, Raimundas Sakalauskas, Kestutis Malakauskas. LSC Abstract – Eosinophils enhance WNT-5a and TGF-β1 genes expression in airway smooth muscle cells and promote their proliferation in asthma. Eur Respir J 2016; 48: Suppl. 60, 632

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Eosinophils promote airway smooth muscle cells contractility and a-actin gene expression in asthma
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018

Eosinophils promote airway smooth muscle cells differentiation to the contractile phenotype in asthma
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019

Eosinophil subtypes’ effect on airway smooth muscle cells differentiation and migration in asthma
Source: Virtual Congress 2020 – Respiratory homeostasis and structural changes in disease
Year: 2020


Co-culture of human airway epithelial cells alter the proliferation of human airway smooth muscle cells
Source: Eur Respir J 2002; 20: Suppl. 38, 572s
Year: 2002

Human airway smooth muscle cell and mast cell interaction is mediated via CD44 and CD51 in asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 712s
Year: 2005

Eotaxin/CCL11 inhibits proliferation of human airway smooth muscle cells
Source: Eur Respir J 2005; 26: Suppl. 49, 127s
Year: 2005

MNK-1 inhibition reduces proliferation and CXCL10 in airway smooth muscle cells
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Cytokines IL-4 and GM-CSF up regulate CD23 expression in human airway smooth muscle cells
Source: Eur Respir J 2004; 24: Suppl. 48, 38s
Year: 2004

Integrins regulate eosinophil adhesion to the airway smooth muscle cells in asthma patients
Source: International Congress 2015 – Asthma mechanisms and management
Year: 2015

DP2/CRTh2 is expressed by ASM cells in asthma and its inhibition suppresses ASM migration
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

Bosentan blocks TNFα-induced GM-CSF expression in human airway smooth muscle cells
Source: Annual Congress 2008 - Basic science in asthma and COPD
Year: 2008

Beta2-agonists but not glucocorticoids inhibit proliferation of asthmatic airway smooth muscle cells
Source: Eur Respir J 2004; 24: Suppl. 48, 251s
Year: 2004

Attenuation of human bronchial smooth muscle cell proliferation by rapamycin in Th2 cytokine dominant status
Source: Eur Respir J 2006; 28: Suppl. 50, 230s
Year: 2006

Mast cell regulation of airway smooth muscle function in asthma
Source: Eur Respir J 2007; 29: 827-830
Year: 2007


IL-25 secreted from epithelial cells has the potential to promote airway remodeling in asthma
Source: Annual Congress 2012 - Asthma and COPD: understanding through mechanisms
Year: 2012

In vivo allergen-activated inflammatory eosinophils reduced airway smooth muscle cells apoptosis in allergic asthma patients
Source: Virtual Congress 2021 – New insights into the airway immunology of lung disease
Year: 2021


Upregulation of airway smooth muscle (ASM) cell apoptosis may limit ASM growth during airway remodeling in experimental asthma
Source: Annual Congress 2008 - Novel mechanisms in the pathogenesis of pulmonary inflammation
Year: 2008

Increased STIM1 expression induced by cigarette smoking extracts regulates the proliferation and production of inflammatory cytokines in human airway smooth muscle cells
Source: Virtual Congress 2020 – Effects of environmental exposures on lung pathology
Year: 2020

Differential regulation of neurotrophin expression in human airway smooth muscle cells by pro-inflammatory cytokines
Source: Eur Respir J 2002; 20: Suppl. 38, 383s
Year: 2002