Induction of pro-fibrotic biomarkers in precision-cut lung slices (PCLS)

Christina Hesse (Hannover, Germany), Christina Hesse, Samuel Mang, Heinz-Gerd Hoymann, Monika Niehof, Peter Braubach, Danny Jonigk, Gregor Warnecke, Olaf Pfennig, Hans-Gerd Fieguth, Armin Braun, Katherina Sewald

Source: International Congress 2016 – IPF pathogenesis
Session: IPF pathogenesis
Session type: Oral Presentation
Number: 479
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Christina Hesse (Hannover, Germany), Christina Hesse, Samuel Mang, Heinz-Gerd Hoymann, Monika Niehof, Peter Braubach, Danny Jonigk, Gregor Warnecke, Olaf Pfennig, Hans-Gerd Fieguth, Armin Braun, Katherina Sewald. Induction of pro-fibrotic biomarkers in precision-cut lung slices (PCLS). Eur Respir J 2016; 48: Suppl. 60, 479

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Cardiotonic agents affect pulmonary vessels in precision-cut lung slices (PCLS)
Source: Annual Congress 2011 - Treatment of pulmonary hypertension
Year: 2011

Relaxin potentiates ß2-adrenoceptor mediated bronchodilation in precision-cut lung slices (PCLS) from mouse models of airway inflammation and fibrosis, and in human airways
Source: International Congress 2019 – Advances in asthma pharmacology
Year: 2019

Comparison of distal lung innervation in human and guinea pig precision-cut lung slices (PCLS)
Source: Annual Congress 2011 - Cell biology of lung disease
Year: 2011

Three-dimensional tissue-based models for translational lung stem cell research: precision-cut lung slices
Source: Eur Respir Monogr 2021; 91: 222-231
Year: 2021


Precision-cut lung slices as an in vitro model for testing of novel therapeutic agents
Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms
Year: 2020


Small airway reactivity is not altered in precision-cut lung slices from a bleomycin mouse model of airway fibrosis
Source: International Congress 2018 – Basic pharmacology
Year: 2018

PP214 – Human precision-cut lung slices generated from excess donor lungs as a model for IPF and drug screening
Source: ERS Lung Science Conference 2021
Year: 2021

Pro-fibrotic biomarkers in ex vivo lung tissue slices: A species comparison
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017

Evaluation of nanoparticles in human lung fibroblasts and PCLS
Source: International Congress 2016 – Therapeutic horizons: novel targets and pharmacological models
Year: 2016

Characterisation of guinea pig precision-cut lung slices: comparison with human tissues
Source: Eur Respir J 2006; 28: 603-611
Year: 2006



Tissue distribution of inhalation drugs in rat lung slices
Source: International Congress 2015 – New models for treating airway diseases
Year: 2015

Precision cut lung slices from bleomycin challenged mice – ex vivo model for testing novel therapies for lung fibrosis
Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease
Year: 2019

Effects of compound salvia miltiorrhiza injection on lung oxidative injury by using rat precision-cut lung slices
Source: Annual Congress 2008 - New therapeutic strategies in idiopathic pulmonary fibrosis
Year: 2008

The effect of nitric oxide in antigen-induced contractions of rat precision-cut lung slices
Source: Eur Respir J 2004; 24: Suppl. 48, 130s
Year: 2004

Free fatty acid receptors, FFAR1 and FFAR4, are novel bronchodilator targets in mouse and human precision-cut lung slices
Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Year: 2018



Ex vivo elastase and hydrogen peroxide stimulation in lung slices: novel models to study lung repair
Source: International Congress 2016 – Therapeutic horizons: novel targets and pharmacological models
Year: 2016


Hemodynamic and respiratory assessement of an ex vivo perfused rat lung model
Source: International Congress 2014 – Maximise lung transplant outcomes: pre- and post-operative issues
Year: 2014

Collagen synthesis in an in vivo rat model of ventilator-induced lung injury
Source: Eur Respir J 2006; 28: Suppl. 50, 397s
Year: 2006

PBI-compound, a novel first-in-class anti-fibrotic compound, inhibits CTGF and collagen production in murine and human fibroblasts, and reduces lung fibrosis in the bleomycin-induced lung fibrosis model
Source: Annual Congress 2013 –Cell signalling and inflammation: what's new in 2013?
Year: 2013


Exosomal messenger RNAs in the airway are potential biomarkers for acute lung injury in mice
Source: International Congress 2015 – Systemic and airway biomarkers
Year: 2015