Cystic fibrosis transmembrane conductance regulator and sphingolipids regulate hypoxic pulmonary vasoconstriction

Christoph Tabeling (Berlin, Germany), Christoph Tabeling, Hanpo Yu, Liming Wang, Hannes Ranke, Neil M. Goldenberg, Diana Zabini, Elena Noe, Adrienn Krauszman, Birgitt Gutbier, Jun Yin, Michael Schaefer, Christoph Arenz, Andreas C. Hocke, Norbert Suttorp, Richard L. Proia, Martin Witzenrath, Wolfgang M. Kuebler

Source: International Congress 2015 – Pulmonary hypertension: promising small molecules
Session: Pulmonary hypertension: promising small molecules
Session type: Poster Discussion
Number: 4905
Disease area: Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Christoph Tabeling (Berlin, Germany), Christoph Tabeling, Hanpo Yu, Liming Wang, Hannes Ranke, Neil M. Goldenberg, Diana Zabini, Elena Noe, Adrienn Krauszman, Birgitt Gutbier, Jun Yin, Michael Schaefer, Christoph Arenz, Andreas C. Hocke, Norbert Suttorp, Richard L. Proia, Martin Witzenrath, Wolfgang M. Kuebler. Cystic fibrosis transmembrane conductance regulator and sphingolipids regulate hypoxic pulmonary vasoconstriction. Eur Respir J 2015; 46: Suppl. 59, 4905

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Expression and function of aquaporin 1 in hypoxia-induced pulmonary hypertension
Source: International Congress 2015 – Pulmonary hypertension: promising small molecules
Year: 2015

Targeting aquaporin 1 reverses hypoxia-induced pulmonary hypertension in mice
Source: International Congress 2016 – The nature of pulmonary hypertension
Year: 2016

Interaction between mitochondrial ROS and ER stress on PHMG-induced pulmonary fibrosis
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016


Role of JAK2/STAT3 pathway in vascular function of pulmonary fibrosis patients
Source: International Congress 2015 – Pulmonary hypertension: promising small molecules
Year: 2015

Interdependence of HIF1alpha /TGFbeta1 activity in induction of pulmonary fibrosis
Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases
Year: 2013


The role of anion exchanger on pulmonary vascular response to sustained alveolar hypoxia in the isolated perfused rabbit lung
Source: International Congress 2014 – Pulmonary hypertension in lung disease
Year: 2014


Contributions of TRPV4 to altered pulmonary vasoreactivity in mice with pulmonary hypertension
Source: Annual Congress 2013 –Pulmonary circulation: animal models and experimental treatments
Year: 2013

Right heart hypertrophy in mice deficient of the mitochondrial regulator protein p66shc is decreased after chronic hypoxic exposure by a cyclophilin D dependent mechanism
Source: International Congress 2014 – Pulmonary hypertension: right ventricle and basic physiology
Year: 2014

PBI-compound, a novel first-in-class anti-inflammatory/fibrotic compound, reduces bleomycin-induced idiopathic pulmonary fibrosis by regulation of extracellular matrix remodelling
Source: Annual Congress 2013 –Novel mechanisms in lung injury
Year: 2013


Sildenafil inhibit dose-dependently profibrotic and remodelling effects of TGFbeta1 on pulmonary arteries from patients with idiopathic pulmonary fibrosis (IPF)
Source: International Congress 2014 – Pulmonary hypertension in lung disease
Year: 2014


SH2 domain-containing phosphatase-SHP-2 is a novel anti-fibrotic regulator in pulmonary fibrosis
Source: International Congress 2016 – Emerging concepts in lung disease pathogenesis
Year: 2016



Specialized-proresolving mediators and trancriptomic signatures in bleomycin-induced lung fibrosis
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

Sulforaphane attenuates lung fibrosis in bleomycin-induced pulmonary fibrosis via inhibition of TGF-beta/Smad signaling
Source: International Congress 2014 – ILDs 4
Year: 2014

Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: Role of transmembrane SCF and PAR-2/PKCalpha/Raf-1/p44/42 signaling pathway
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

The immunomodulatory effect of protein S in pulmonary fibrosis
Source: Annual Congress 2013 –Diffuse pulmonary fibrosis
Year: 2013


LATE-BREAKING ABSTRACT: Reducing inflammation in the lung by targeting the endothelial cystic fibrosis transmembrane conductance regulator with copper-tobramycin
Source: International Congress 2014 – Cystic fibrosis: genotypes, inflammation and microbiology
Year: 2014

Intact serotonin signaling is not required for the development of severe angioproliferative pulmonary hypertension in rats
Source: International Congress 2014 – Pathobiology of pulmonary hypertension
Year: 2014

Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries
Source: Eur Respir J 2007; 30: 857-864
Year: 2007



Effects of NecroX compounds on bleomycin-induced pulmonary fibrosis
Source: International Congress 2016 – IPF: from pathogenesis to treatment I
Year: 2016


The role of extracellular vesicles in phenotypic alteration of lung cells in pulmonary fibrosis
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013