Tissue distribution of inhalation drugs in rat lung slices

Erica Bäckström (Mölndal, Sweden), Erica Bäckström, Anders Lundqvist, Elin Boger, Petter Svanberg, Pär Ewing, Margareta Hammarlund-Udenaes, Markus Fridén

Source: International Congress 2015 – New models for treating airway diseases
Session: New models for treating airway diseases
Session type: Poster Discussion
Number: 3578
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Erica Bäckström (Mölndal, Sweden), Erica Bäckström, Anders Lundqvist, Elin Boger, Petter Svanberg, Pär Ewing, Margareta Hammarlund-Udenaes, Markus Fridén. Tissue distribution of inhalation drugs in rat lung slices. Eur Respir J 2015; 46: Suppl. 59, 3578

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Lung absorption half-life of inhaled drugs can be predicted with rat lung slices
Source: International Congress 2015 – New models for treating airway diseases
Year: 2015

Hemodynamic and respiratory assessement of an ex vivo perfused rat lung model
Source: International Congress 2014 – Maximise lung transplant outcomes: pre- and post-operative issues
Year: 2014

Antioxidant effects of bisphosphonates in smoking- induced lung injury in rat model
Source: International Congress 2015 – New models for treating airway diseases
Year: 2015


Development of a lung slice methodology to study the mechanisms of lung uptake and lysosomal trapping
Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Year: 2014


CHI-91040, a novel inhaled p38α inhibitor, counteracts lung inflammation induced by IL-1β in the rat
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

Intra tracheal instillation of BMSC-cm attenuate acute rejection in rat lung allotransplantation
Source: International Congress 2016 – Lung allograft dysfunction: insights into inflammatory/immune mechanisms
Year: 2016

Effect of inhaled liposomal retinoids on the hyperoxia induced lung injury in newborn guinea pigs
Source: International Congress 2014 – New and old players in fibrotic lung disease
Year: 2014


The anti-inflammatory effects of PF03715455 and roflumilast on both cellular and tissue inflammation in a mouse model of COPD
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013

Effects of tobacco smoke and poly IC, alone and in combination, on mouse lung pathology
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013


Deposition and pulmonary effect of nanoparticle in whole body inhalation study and in nose only inhalation study
Source: International Congress 2015 – Occupational and environmental effects: in vitro and animal models
Year: 2015

Inhalation of chlorine causes lung inflammation and airway hyperresponsiveness in a rat model of chemical-induced lung injury
Source: International Congress 2015 – Inflammation and remodelling in lung disease
Year: 2015

Effect of diminazene on monocrotalin-induced pulmonary hypertension rat model
Source: International Congress 2015 – Pulmonary hypertension: novel insights into the biology of the disease
Year: 2015

Intratracheal administration of dry powdered low-molecular-weight chitosan/siRNA complexes suppressed gene expression in the airway, alveoli, and metastatic tumors in murine lung
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013

Nicotine impairs inflammation-induced airway relaxation in a in vitro murine model of asthma
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013


Prediction of human lung PK for AZD7624, an inhaled P38 inhibitor for the treatment of COPD
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

Acute markers of neutrophilic lung infiltration in the non-human primate LPS model
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014


Forced oscillation technique for evaluation of ex vivo perfused pig lungs
Source: International Congress 2014 – Maximise lung transplant outcomes: pre- and post-operative issues
Year: 2014


Adipose derived stem cells ameliorate airway inflammation in mouse models of asthma
Source: International Congress 2015 – Asthma and lung immunology
Year: 2015


The effects of intra-nasally administered anti-inflammatory compounds in a mouse model of acute COPD exacerbations
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013