Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating hypoxic signaling

Olivier Bernard (Bobigny, France), Olivier Bernard, Florence Jeny, Elisabetta Dondy, Yurdagül Uzunhan, Shalini Sivarajah, Valérie Vanneaux, Jérôme Larghero, Hilario Nunès, Carole Planès, Nicolas Dard

Source: International Congress 2015 – The multiple facets of stem and progenitor cells in lung health and disease
Session: The multiple facets of stem and progenitor cells in lung health and disease
Session type: Oral Presentation
Number: 3517
Disease area: Interstitial lung diseases

Congress or journal article abstractE-posterSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Olivier Bernard (Bobigny, France), Olivier Bernard, Florence Jeny, Elisabetta Dondy, Yurdagül Uzunhan, Shalini Sivarajah, Valérie Vanneaux, Jérôme Larghero, Hilario Nunès, Carole Planès, Nicolas Dard. Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating hypoxic signaling. Eur Respir J 2015; 46: Suppl. 59, 3517

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Human mesenchymal stem cell exosomes attenuate inflammation of lung epithelial cells through miR-223 in acute lung injury
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

Generation of an immortalized functional alveolar epithelial cell line originating from human induced pluripotent stem cells
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

Regulation and role of notch signaling in epithelial progenitor cell differentiation and proliferation in the normal and the fibrotic lung
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis: pathogenesis
Year: 2013

Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury
Source: Eur Respir J, 59 (1) 2004216; 10.1183/13993003.04216-2020
Year: 2022



Low oxygen tension enhances the generation of lung progenitor cells from mouse embryonic and induced pluripotent stem cells
Source: International Congress 2014 – Lung cell biology in injury and repair
Year: 2014


LATE-BREAKING ABSTRACT: Tissue-resident epithelial stem/progenitor cells in pulmonary epithelial repair
Source: International Congress 2015 – Inflammation and remodelling in lung disease
Year: 2015

SIRT6-induced activation of autophagy inhibits CSE-induced bronchial epithelial cell senescence
Source: Annual Congress 2013 –New insights into epigenetic mechanisms in the lung
Year: 2013

Multipotent stromal cell-derived stanniocalcin-1 reduces reactive oxygen species and promotes survival of injured A549 lung cancer cells through upregulation of uncoupling-protein 2 and induction of the Warburg effect
Source: Annual Congress 2010 - New insights into reactive oxygen species
Year: 2010


Protective effect of mesenchymal stem cells (MSC) on hypoxia-induced epithelial-mesenchymal transition of alveolar epithelial cells (AEC)
Source: Annual Congress 2012 - Lung injury and repair: reactive oxygen species and beyond
Year: 2012

Late Breaking Abstract - WNT/ß-catenin signaling induces cellular senescence in lung alveolar epithelial cells
Source: International Congress 2019 – Oxidative stress, hypoxia and microbial exposure in the pathogenesis of pulmonary disease
Year: 2019

Secreted mediators from induced pluripotent stem cells (iPSc) attenuate fibrosis in bleomycin injured rat lung
Source: Annual Congress 2012 - Stem cells and progenitors in injury and repair
Year: 2012

HDAC inhibitors may regulate EMT and surfactant protein C in human alveolar epithelial cells
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015

Krüppel-like Factor 4 is a Stat3-Smad2 regulator in ATII cells determining ATII cell fate during lung development and hyperoxia-induced lung injury
Source: International Congress 2019 – Molecular and experimental paediatric lung disease
Year: 2019



Protective roles of paracrine factors of bone marrow mesenchymal stem cells in bleomycin induced lung epithelial cell injury in vitro and pulmonary fibrosis in vivo
Source: Annual Congress 2010 - Experimental approaches in pulmonary fibrosis
Year: 2010


Mesenchymal stem cells isolated from fibrotic human lung tissue inhibit collagen expression by lung fibroblasts
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

The enhancement of Stanniocalcin-1 (STC1) secretion increases the ability of mesenchymal stem cells (MSCs) to reduce bleomycin-induced lung fibrosis in a mouse model through inhibition of endoplasmic reticulum stress (ER-stress)/TGFbeta1 pathway
Source: International Congress 2014 – ILDs 1
Year: 2014


Induced pluripotent stem cells for generating lung alveolar epithelial cells and modelling respiratory disease
Source: Eur Respir Monogr 2021; 91: 205-221
Year: 2021


Assessment of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Apoptosis and non-apoptotic cell death induced by mechanical stress in alveolar type II cells and pulmonary microvascular endothelial cells
Source: Eur Respir J 2003; 22: Suppl. 45, 587s
Year: 2003