Activation of TRPV4 triggers ATP release and mast cell dependent contraction of airway smooth muscle (ASM)

Sara Bonvini (London, United Kingdom), Sara Bonvini, Mark Birrell, Eric Dubuis, John Adcock, Victoria Jones, Pauline Flajolet, Sepideh Poushpas, Mengqi Wang, S. Mark Duffy, Peter Bradding, Kevin Langley, Maria Belvisi

Source: International Congress 2015 – Novel targets and strategies for the treatment of cough, asthma, rhinosinusitis and COPD
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Sara Bonvini (London, United Kingdom), Sara Bonvini, Mark Birrell, Eric Dubuis, John Adcock, Victoria Jones, Pauline Flajolet, Sepideh Poushpas, Mengqi Wang, S. Mark Duffy, Peter Bradding, Kevin Langley, Maria Belvisi. Activation of TRPV4 triggers ATP release and mast cell dependent contraction of airway smooth muscle (ASM). Eur Respir J 2015; 46: Suppl. 59, 3253

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
IL33 and TNFalpha synergistically enhance store operated Ca2+ entry in cultured human airway smooth muscle cells
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013


TGF-beta alters TRPC6 expression and calcium handling via smad2/3 in human airway smooth muscle
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013


A functional role for WNT-5A in driving airway myocyte proliferation
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013


The effect of adenosine on VEGF release from airway smooth muscle from subjects with asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Impaired inhibitory action of corticosteroids on chemokine expression induced by TNFalpha in airway smooth muscle (ASM) cells from patients with severe asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Compound A modulates steroid insensitive chemokines in airway smooth muscle cells via IRF-1 dependent and independent pathways
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

DP2/CRTh2 is expressed by ASM cells in asthma and its inhibition suppresses ASM migration
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

MNK-1 inhibition reduces proliferation and CXCL10 in airway smooth muscle cells
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

HMGB1 is upregulated in ASM in asthma and induces ASM contraction via TLR4
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

Compound A (CpdA) suppressed production of corticosteroid-resistant chemokines via GR-independent mechanisms in airway smooth muscle (ASM) cells
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013

FGF-2 modulates human airway smooth muscle contractile protein expression and cell stiffness
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

The c-jun N-terminal kinase signaling pathway regulates airway smooth muscle cell proliferation
Source: International Congress 2014 – Cell biology 2014
Year: 2014


Eosinophil-induced airway smooth muscle cells remodeling is attenuated by blocking of RGD-binding integrins in asthma
Source: International Congress 2016 – New findings in mucosal immunology
Year: 2016

CCL2 release by airway smooth muscle is increased in asthma and promotes fibrocyte migration
Source: International Congress 2014 – Cell biology 2014
Year: 2014


Syk mediates airway contractility independently of leukocyte function
Source: Annual Congress 2013 –Murine models of lung immunology
Year: 2013

Role of protein phosphatase 5 (PP5) in mediating corticosteroid insensitivity in airway smooth muscle (ASM) cells in severe asthma
Source: International Congress 2015 – New insights into lung disease pathogenesis
Year: 2015

Regulation of actin dynamics by WNT-5A: Implications for human airway smooth muscle contraction
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016


Caveolin-1 regulation of store-operated Ca2+ influx in human airway smooth muscle
Source: Eur Respir J 2012; 40: 470-478
Year: 2012



Glutathionylation of IκB-α inhibits NF-κB dependent chemokine secretion in airway smooth muscle cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010