Allosteric inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) slows airway mucus transport in normal sheep

W. M. Abraham (Miami Beach, United States of America), William Abraham, Juan Sabater, Tahir Ahmed

Source: International Congress 2015 – Cystic fibrosis: physiology, biomarkers, microbiology and miscellaneous
Session: Cystic fibrosis: physiology, biomarkers, microbiology and miscellaneous
Session type: Poster Discussion
Number: 2054
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
W. M. Abraham (Miami Beach, United States of America), William Abraham, Juan Sabater, Tahir Ahmed. Allosteric inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) slows airway mucus transport in normal sheep. Eur Respir J 2015; 46: Suppl. 59, 2054

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Cystic fibrosis transmembrane conductance regulator pharmacotherapy
Source: ISSN=ISSN 1025-448x, ISBN=ISBN 1-904097-46-6, page=88
Year: 2006

Pharmacology and regulation of ENaC function: implication in cystic fibrosis
Source: Annual Congress 2009 - Novel regulators of alveolar liquid clearance
Year: 2009


A three miRNA signature regulates the CF transmembrane conductance regulator (CFTR) in cystic fibrosis airway epithelium
Source: Annual Congress 2011 - Epithelial cells: role in health and disease
Year: 2011

Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration
Source: Eur Respir J, 59 (2) 2100185; 10.1183/13993003.00185-2021
Year: 2022



Channelopathies in bronchiectasis
Source: Eur Respir Mon 2011; 52: 150-162
Year: 2011


Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis
Source: Eur Respir Rev 2013; 22: 58-65
Year: 2013



Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator (CFTR) ion transport
Source: Annual Congress 2013 –Cystic fibrosis: basic and applied science
Year: 2013

The cystic fibrosis transmembrane conductance regulator and its modulators: clinical implications
Source: Virtual Congress 2020 – Respiratory infections
Year: 2020


Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries
Source: Eur Respir J 2007; 30: 857-864
Year: 2007



How organoids helped to discover cystic fibrosis transmembrane conductance regulator (CFTR) therapeutics and predict response to treatment
Source: International Congress 2016 – Closing the gap: novel translational research strategies
Year: 2016


Pharmacological treatment of the biochemical defect in cystic fibrosis airways
Source: Eur Respir J 2001; 17: 1314-1321
Year: 2001



Cystic fibrosis transmembrane conductance regulator and sphingolipids regulate hypoxic pulmonary vasoconstriction
Source: International Congress 2015 – Pulmonary hypertension: promising small molecules
Year: 2015

The potential interaction of MARCKS-related peptide and diltiazem on acrolin-induced airway mucus hypersecretion in rats
Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Year: 2013

LATE-BREAKING ABSTRACT: Reducing inflammation in the lung by targeting the endothelial cystic fibrosis transmembrane conductance regulator with copper-tobramycin
Source: International Congress 2014 – Cystic fibrosis: genotypes, inflammation and microbiology
Year: 2014

TRPV4 and activation of airway sensory nerves: The role of ATP
Source: International Congress 2015 – Novel targets and strategies for the treatment of cough, asthma, rhinosinusitis and COPD
Year: 2015

ENaC inhibition in cystic fibrosis: potential role in the new era of CFTR modulator therapies
Source: Eur Respir J, 56 (6) 2000946; 10.1183/13993003.00946-2020
Year: 2020



Type II transmembrane serine protease matriptase is a mediator of pulmonary fibrosis
Source: Annual Congress 2013 –Translational studies in chronic repair and remodelling in the lung
Year: 2013


Transient receptor potential channels in a mouse model of isocyanate-induced airway hyperresponsiveness
Source: International Congress 2014 – Mechanistic murine studies of asthma and lung inflammation
Year: 2014

The cystic fibrosis transmembrane conductance regulator: state of the art
Source: Breathe 2008; 5: 163-167
Year: 2008