A short splice variant of the tumor suppressor gene CYLD induces allergic airway disease in mice and is also expressed in humans

Sebastian Reuter (Mainz, Germany), Sebastian Reuter, Hendrik Beckert, Helen Meyer-Martin, Ari Waisman, Roland Buhl, Michael Stassen, Christian Taube

Source: International Congress 2015 – Advances in asthma and allergy in animal models
Session: Advances in asthma and allergy in animal models
Session type: Oral Presentation
Number: 2003
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Sebastian Reuter (Mainz, Germany), Sebastian Reuter, Hendrik Beckert, Helen Meyer-Martin, Ari Waisman, Roland Buhl, Michael Stassen, Christian Taube. A short splice variant of the tumor suppressor gene CYLD induces allergic airway disease in mice and is also expressed in humans. Eur Respir J 2015; 46: Suppl. 59, 2003

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model
Source: International Congress 2015 – Asthma and lung immunology
Year: 2015


Characterization of an endogenous Th17-cell generation during sensitization in the murine lung
Source: International Congress 2015 – Immune mechanisms in the human lung
Year: 2015

T cell specific expression of a short splice variant of the tumor suppressor gene CYLD amplifies the development of allergic airway disease
Source: Annual Congress 2011 - T-cell subsets
Year: 2011

Activation of the β-catenin pathway by Wnt-1 treatment suppress inflammation in the mouse model of allergic airway disease
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015


Deletion of peroxiredoxin 6 potentiates OVA-induced asthma epithelial-mesenchymal transition through EGFR pathway
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma (AIA)
Source: Annual Congress 2013 –Genetics and mechanisms of, and tests for, allergy
Year: 2013

Treatment with Syk inhibitors after establishment of disease phenotype in a chronic HDM model of allergic airways inflammation abolishes AHR and attenuates inflammatory mediator expression
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

BmTI-A, a serine protease inhibitor, reduces the chronic allergic lung inflammation in a mice model
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

LATE-BREAKING ABSTRACT: MUC1 downregulation induces corticosteroid resistance in asthma’s in vitro and in vivo models
Source: International Congress 2016 – Therapeutic horizons: novel targets and pharmacological models
Year: 2016

IL33 and TSLP involvements in influenza-induced exacerbation in a murine model of chronic asthma
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015

A murine ovalbumin model exhibits molecular features of steroid insensitive human asthma
Source: International Congress 2015 – New insights into lung disease pathogenesis
Year: 2015

Aquaporin-3 potentiates murine asthma through mediating T-cell trafficking and chemokine production
Source: International Congress 2016 – Pharmacological intervention in humans and murine models of asthma
Year: 2016


The development of an allergic airway disease is influenced by a short splice variant of CYLD
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

Autoimmune induction of a COPD-like inflammatory phenotype in mice
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013

The homologous IL-17 cytokines A and F differentially regulate allergic asthma in murine models
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015

Exosomal microRNAs in the serum are potential real-time biomarkers for allergic inflammation in the airway of mice
Source: International Congress 2014 – Mechanistic murine studies of asthma and lung inflammation
Year: 2014


Mapping a mouse model of severe asthma to human asthma using gene set variation analysis
Source: International Congress 2015 – Advances in the future treatment of severe asthma
Year: 2015

IL-37 requires IL18Rα and SIGIRR to diminish experimental allergic airway inflammation in mice
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Changes in epithelial barrier components E-cadherin, Beta-catenin, EGR with steroid treatment in murine model of asthma
Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Year: 2015


Immunohistochemical study on changes of mast cell populations during allergic airway inflammation in mice using HDM model
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015