The secretome of induced pluripotent stem cells (iPSC) modulates macrophage phenotype in the fibrotic lung

Luca Tamò (Bern, Switzerland), Luca Tamò, Amiq Gazdhar, Anis Feki, Thomas Geiser

Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Session: Pulmonary fibrosis: mechanisms of disease
Session type: Thematic Poster Session
Number: 944
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Luca Tamò (Bern, Switzerland), Luca Tamò, Amiq Gazdhar, Anis Feki, Thomas Geiser. The secretome of induced pluripotent stem cells (iPSC) modulates macrophage phenotype in the fibrotic lung. Eur Respir J 2015; 46: Suppl. 59, 944

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Pluripotent stem cells isolated from adult human lung tissue exhibit anti-fibrotic properties
Source: Annual Congress 2013 –Translational studies in chronic repair and remodelling in the lung
Year: 2013

Regulation and role of notch signaling in epithelial progenitor cell differentiation and proliferation in the normal and the fibrotic lung
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis: pathogenesis
Year: 2013

Generation of an immortalized functional alveolar epithelial cell line originating from human induced pluripotent stem cells
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

The enhancement of Stanniocalcin-1 (STC1) secretion increases the ability of mesenchymal stem cells (MSCs) to reduce bleomycin-induced lung fibrosis in a mouse model through inhibition of endoplasmic reticulum stress (ER-stress)/TGFbeta1 pathway
Source: International Congress 2014 – ILDs 1
Year: 2014


Targetingpyruvate kinase M2 isoform inhibits proliferation of human lung fibroblasts
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

Reactivation of developmental pathways in idiopathic pulmonary fibrosis: FGF9 and FGF18 modulate the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

Induced pluripotent stem cells conditioned media (iPS-cm) modulates macrophage phenotype in the fibrotic lung
Source: International Congress 2014 – Lung cell biology in injury and repair
Year: 2014

Rescue of murine silica-induced lung injury and fibrosis by human embryonic stem cells
Source: Eur Respir J 2012; 39: 446-457
Year: 2012



LSC - 2021 - Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids
Source: Virtual Congress 2021 – In vitro modelling of lung disease: reach out to the next dimension
Year: 2021


Distinct gene expression profiles of cultured stromal cells from the patients with idiopathic pulmonary fibrosis and lung adenocarcinoma
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015

Mesenchymal stem cells and conditioned medium in myofibroblast modulation and collagen production in vascular adventitia and parenchyma of experimental pulmonary fibrosis model
Source: International Congress 2016 – ILD pathogenesis
Year: 2016

ATF3 regulates PINK1 transcription in lung epithelial cells of the aging lung
Source: International Congress 2016 – Repair pathways: from lung development to ageing of the lung
Year: 2016

Identification and characterization of mesenchymal stem cells in the human lung
Source: International Congress 2015 – Cellular and molecular mechanisms of COPD and emphysema
Year: 2015

Lung-derived mesenchymal stromal cells are tissue specific and display an altered gene expression in BOS patients
Source: International Congress 2015 – The multiple facets of stem and progenitor cells in lung health and disease
Year: 2015

PP206 – Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids
Source: ERS Lung Science Conference 2021
Year: 2021

Mesenchymal stem cells isolated from fibrotic human lung tissue inhibit collagen expression by lung fibroblasts
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology
Source: Eur Respir J 2010; 35: 496-504
Year: 2010



LSC Abstract – Network analysis of induced pluripotent stem cells secretome reveales its anti fibrotic action in rat lung injury model
Source: International Congress 2016 – New therapies and therapeutic targets
Year: 2016


Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: Role of transmembrane SCF and PAR-2/PKCalpha/Raf-1/p44/42 signaling pathway
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013